Imperial College London
Alternate

Professor Graham P Taylor

Faculty of Medicine, Department of Infectious Disease

Professor of Human Retrovirology
 
 
 
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Contact

 

+44 (0)20 7594 3910g.p.taylor Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Elliott:2021,
author = {Elliott, P and Bodinier, B and Eales, O and Wang, H and Haw, D and Elliott, J and Whitaker, M and Jonnerby, J and Tang, D and Walters, C and Atchison, C and Diggle, P and Page, A and Trotter, A and Ashby, D and Barclay, W and Taylor, G and Ward, H and Darzi, A and Cooke, G and Chadeau-Hyam, M and Donnelly, C},
title = {Rapid increase in Omicron infections in England during December 2021: REACT-1 study},
url = {http://hdl.handle.net/10044/1/93241},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background: The highest-ever recorded numbers of daily severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in England has been observed during December 2021 and have coincided with a rapid rise in the highly transmissible Omicron variant despite high levels of vaccination in the population. Although additional COVID-19 measures have beenintroduced in England and internationally to contain the epidemic, there remains uncertainty about the spread and severity of Omicron infections among the general population.Methods: The REal-time Assessment of Community Transmission–1 (REACT-1) study has been monitoring the prevalence of SARS-CoV-2 infection in England since May 2020.REACT-1 obtains self-administered throat and nose swabs from a random sample of the population of England at ages 5 years and over. Swabs are tested for SARS-CoV-2 infection by reverse transcription polymerase chain reaction (RT-PCR) and samples testing positive are sent for viral genome sequencing. To date 16 rounds have been completed, each including~100,000 or more participants with data collected over a period of 2 to 3 weeks per month.Socio-demographic, lifestyle and clinical information (including previous history of COVID-19 and symptoms prior to swabbing) is collected by online or telephone questionnaire. Here we report results from round 14 (9-27 September 2021), round 15 (19 October - 05 November2021) and round 16 (23 November - 14 December 2021) for a total of 297,728 participants with a valid RT-PCR test result, of whom 259,225 (87.1%) consented for linkage to their NHS records including detailed information on vaccination (vaccination status, date). We usedthese data to estimate community prevalence and trends by age and region, to evaluate vaccine effectiveness against infection in children ages 12 to 17 years, and effect of a third (booster) dose in adults, and to monitor the emergence of the Omicron variant in England.Results: We observed a high overall prevalen
AU  - Elliott,P
AU  - Bodinier,B
AU  - Eales,O
AU  - Wang,H
AU  - Haw,D
AU  - Elliott,J
AU  - Whitaker,M
AU  - Jonnerby,J
AU  - Tang,D
AU  - Walters,C
AU  - Atchison,C
AU  - Diggle,P
AU  - Page,A
AU  - Trotter,A
AU  - Ashby,D
AU  - Barclay,W
AU  - Taylor,G
AU  - Ward,H
AU  - Darzi,A
AU  - Cooke,G
AU  - Chadeau-Hyam,M
AU  - Donnelly,C
PY  - 2021///
TI  - Rapid increase in Omicron infections in England during December 2021: REACT-1 study
UR  - http://hdl.handle.net/10044/1/93241
ER  -
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