Imperial College London
Alternate

Professor Graham P Taylor

Faculty of Medicine, Department of Infectious Disease

Professor of Human Retrovirology
 
 
 
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Contact

 

+44 (0)20 7594 3910g.p.taylor Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barr:2022:10.3389/fmed.2022.941647,
author = {Barr, R and Drysdale, S and Boullier, M and Lyall, H and Cook, L and Collins, G and Kelly, D and Phelan, L and Taylor, G},
doi = {10.3389/fmed.2022.941647},
journal = {Frontiers in Medicine},
pages = {1--7},
title = {A review of the prevention of mother-to-child transmission of human T-cell lymphotropic virus type 1 (HTLV-1) with a proposed management algorithm},
url = {http://dx.doi.org/10.3389/fmed.2022.941647},
volume = {9},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Human T cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that is endemic in a number of regions across the world. There are an estimated 5-10 million people infected worldwide. Japan is currently the only country with a national antenatal screening programme in place. HTLV-1 is primarily transmitted sexually in adulthood, however it can be transmitted from mother-to-child perinatally. This can occur transplacentally, during the birth process or via breastmilk. If HTLV-1 is transmitted perinatally then the lifetime risk of adult T cell leukaemia/lymphoma rises from 5% to 20%, therefore prevention of mother-to-child transmission of HTLV-1 is a public health priority. There are reliable immunological and molecular tests available for HTLV-1 diagnosis during pregnancy and screening should be considered on a country by country basis. Further research on best management is needed particularly for pregnancies in women with high HTLV-1 viral load. A first step would be to establish an international registry of cases and to monitor outcomes for neonates and mothers.  We have summarised key risk factors for mother-to-child transmission of HTLV-1 and subsequently propose a pragmatic guideline for management of mothers and infants in pregnancy and the perinatal period to reduce the risk of transmission. This is clinically relevant in order to reduce mother-to-child transmission of HTLV-1 and it’s complications.
AU  - Barr,R
AU  - Drysdale,S
AU  - Boullier,M
AU  - Lyall,H
AU  - Cook,L
AU  - Collins,G
AU  - Kelly,D
AU  - Phelan,L
AU  - Taylor,G
DO  - 10.3389/fmed.2022.941647
EP  - 7
PY  - 2022///
SN  - 2296-858X
SP  - 1
TI  - A review of the prevention of mother-to-child transmission of human T-cell lymphotropic virus type 1 (HTLV-1) with a proposed management algorithm
T2  - Frontiers in Medicine
UR  - http://dx.doi.org/10.3389/fmed.2022.941647
UR  - https://www.frontiersin.org/articles/10.3389/fmed.2022.941647/full
UR  - http://hdl.handle.net/10044/1/98196
VL  - 9
ER  -
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