Imperial College London
Alternate

Professor Graham P Taylor

Faculty of Medicine, Department of Infectious Disease

Professor of Human Retrovirology
 
 
 
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Contact

 

+44 (0)20 7594 3910g.p.taylor Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Takele:2023:10.1016/j.isci.2022.105867,
author = {Takele, Y and Mulaw, T and Adem, E and Womersley, R and Kaforou, M and Franssen, SU and Michael, levin and Taylor, GP and Müller, I and Cotton, JA and Kropf, P},
doi = {10.1016/j.isci.2022.105867},
journal = {iScience},
pages = {1--22},
title = {Recurrent visceral leishmaniasis relapses in HIV co-infected patients are characterised by less efficient immune responses and higher parasite load},
url = {http://dx.doi.org/10.1016/j.isci.2022.105867},
volume = {26},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Visceral leishmaniasis (VL) and HIV co-infection (VL/HIV) has emerged as a significant public health problem in Ethiopia, with up to 30% of patients with VL co-infected with HIV. These patients suffer from recurrent VL relapses and increased mortality. Those with a previous history of VL relapses (recurrent VL/HIV) experience increased VL relapses as compared to patients with HIV presenting with their first episode of VL (primary VL/HIV). Our aim was to identify drivers that account for the higher rate of VL relapses in patients with recurrent VL/HIV (n = 28) as compared to primary VL/HIV (n = 21). Our results show that the relapse-free survival in patients with recurrent VL/HIV was shorter, that they had higher parasite load, lower weight gain, and lower recovery of all blood cell lineages. Their poorer prognosis was characterized by lower production of IFN-gamma, lower CD4+ T cell counts, and higher expression of programmed cell death protein 1 (PD1) on T cells.
AU  - Takele,Y
AU  - Mulaw,T
AU  - Adem,E
AU  - Womersley,R
AU  - Kaforou,M
AU  - Franssen,SU
AU  - Michael,levin
AU  - Taylor,GP
AU  - Müller,I
AU  - Cotton,JA
AU  - Kropf,P
DO  - 10.1016/j.isci.2022.105867
EP  - 22
PY  - 2023///
SN  - 2589-0042
SP  - 1
TI  - Recurrent visceral leishmaniasis relapses in HIV co-infected patients are characterised by less efficient immune responses and higher parasite load
T2  - iScience
UR  - http://dx.doi.org/10.1016/j.isci.2022.105867
UR  - https://www.sciencedirect.com/science/article/pii/S258900422202140X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101627
VL  - 26
ER  -
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