Imperial College London

DrGregoryQuinlan

Faculty of MedicineNational Heart & Lung Institute

Senior Research Fellow
 
 
 
//

Contact

 

g.quinlan

 
 
//

Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Publication Type
Year
to

157 results found

Hector LR, Lagan AL, Melley DD, Pantelidis P, Creagh-Brown B, Finney SJ, Evans TW, Quinlan GJet al., 2011, Polymorphisms in the haptoglobin gene predispose patients to adverse outcome after surgery necessitating cardiopulmonary bypass, Am J Respir Crit Care Med, American Thoracic Society International Congress, Pages: A1161-A1161

Conference paper

Leaver SK, Quinlan GJ, Evans TW, Burke-Gaffney Aet al., 2010, THIOREDOXIN MODIFIES MIF RELEASE FROM HUMAN MONOCYTES FOLLOWING STIMULATION WITH LTA AND LPS, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A25-A26, ISSN: 0040-6376

Conference paper

Zakeri N, Creagh-Brown B, Hector LR, Hewitt RJ, Lagan AL, Quinlan GJ, Pantelidis Pet al., 2010, POLYMORPHISMS IN GENES ENCODING RAGE OR RAGE LIGANDS PREDISPOSE PATIENTS TO ADVERSE OUTCOMES FOLLOWING SURGERY NECESSITATING CARDIOPULMONARY BYPASS, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A49-A49, ISSN: 0040-6376

Conference paper

Creagh-Brown BC, Quinlan GJ, Evans TW, Burke-Gaffney Aet al., 2010, The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?, INTENSIVE CARE MEDICINE, Vol: 36, Pages: 1644-1656, ISSN: 0342-4642

Journal article

Quinlan GJ, 2010, Oxidative damage to extracellular proteins and lipids during acute lung injury.

Journal article

Creagh-Brown BC, Quinlan GJ, Evans TW, 2010, RAGE inhibition: Healthy or harmful?, CRITICAL CARE MEDICINE, Vol: 38, Pages: 1487-1490, ISSN: 0090-3493

Journal article

Leaver SK, MacCallum NS, Pingle V, Hacking MB, Quinlan GJ, Evans TW, Burke-Gaffney Aet al., 2010, Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor., Intensive Care Med, Vol: 36, Pages: 336-341, ISSN: 1432-1238

PURPOSE: To establish the relationship between plasma levels of thioredoxin (Trx) and macrophage migration inhibitory factor (MIF) in systemic inflammatory stress syndrome (SIRS)/sepsis. METHODS: Enzyme-linked immunosorbent assay measurements of Trx, MIF, IL-6, -8, and -10 and enzyme-linked fluorescent assay determination of procalcitonin (PCT) in plasma from patients with SIRS/sepsis, neutropenic sepsis, healthy volunteers and pre-oesophagectomy patients. RESULTS: Thioredoxin was significantly higher in SIRS/sepsis patients [101.3 ng ml(-1), interquartile range (IQR) 68.7-155.6, n = 32] compared with that in healthy controls (49.5 ng ml(-1), IQR 31.4-71.1, P < 0.001, n = 17) or pre-oesophagectomy patients (40.5 ng ml(-1), IQR 36.9-63.2, P < 0.01, n = 7), but was not raised in neutropenics (n = 5). MIF levels were also significantly higher in SIRS/sepsis patients (12.1 ng ml(-1), IQR 9.5-15.5, n = 35), but not in the neutropenic group, when compared with healthy controls (9.3 ng ml(-1), IQR 7.3-10.7, P < 0.01, n = 20). Trx levels correlated, positively, with MIF levels and APACHE II scores. Plasma levels of IL-6, -8 and -10 and PCT increased significantly in patients with SIRS/sepsis (P < 0.001) and with neutropenic sepsis, but did not correlate with Trx or MIF levels. CONCLUSION: Plasma levels of Trx, MIF, IL-6, -8, -10 and PCT were raised in patients with SIRS/sepsis. Comparisons between mediators suggest a unique correlation of Trx with MIF. Moreover, Trx and MIF differed from cytokines and PCT in that levels were significantly lower in patients with neutropenia compared with the main SIRS/sepsis group. By contrast, IL-8 and PCT levels were significantly greater in the neutropenic patient group. The link between MIF and Trx highlighted in this study has implications for future investigations into the pathogenesis of SIRS/sepsis.

Journal article

Bastin AJ, Lagan AL, Mumby S, Quinlan GJ, Griffiths MJDet al., 2010, Effect Of N-acetylcysteine In Preventing Inflammation After Lung Resection And One-Lung Ventilation. A Randomised Controlled Trial., Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Hector LR, Lagan AL, Melley DD, Evans TW, Quinlan GJet al., 2010, Hemoglobin Release, Genetic Polymorphism And Adverse Outcome From Surgery Necessitating Cardiopulmonary Bypass, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X

Journal article

Bundy RE, Melley DD, Hector LR, Goode E, Lagan AL, Finney S, Quinlan GJ, Evans TWet al., 2010, Albumin Inhibits Heme Mediated Delay Of Spontaneous Neutrophil Apoptosis, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Lagan AL, Hewitt RJ, Melley DD, Hector LR, Pantelidis P, Finney SJ, Evans TW, Quinlan GJet al., 2010, Adverse Outcomes From Cardiac Surgery Requiring Cardiopulmonary Bypass: Influence Of Polymorphism In Genes Encoding A Panel Of Cytokines, Am J Respir Crit Care Med, American Thoracic Society International Congress, Pages: A1161-A1161

Conference paper

Goode EF, Hector LR, Lagan AL, Melley DD, Quinlan GJ, Bundy REet al., 2009, INFLUENCE OF CARDIAC SURGERY UTILISING CARDIOPULMONARY BYPASS ON NEUTROPHIL-RELATED PROINFLAMMATORY RESPONSES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A49-A49, ISSN: 0040-6376

Conference paper

Hewitt RJ, Melley DD, Hector LR, Pantelidis P, Finney SJ, Evans TW, Quinlan GJ, Lagan ALet al., 2009, POLYMORPHISMS IN INFLAMMATORY PATHWAY GENES PREDISPOSE PATIENTS TO ADVERSE OUTCOMES AFTER CARDIOPULMONARY BYPASS SURGERY, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A26-A27, ISSN: 0040-6376

Conference paper

Lagan AL, Quinlan GJ, Evans TW, 2009, Haem oxygenase-1 polymorphism and ARDS, friend and foe?, INTENSIVE CARE MEDICINE, Vol: 35, Pages: 1325-1327, ISSN: 0342-4642

Journal article

Burke-Gaffney A, Evans TW, Quinlan GJ, 2009, Thioredoxin in sepsis: Just another biomarker or a plausible therapeutic target?, CRITICAL CARE MEDICINE, Vol: 37, Pages: 2304-2305, ISSN: 0090-3493

Journal article

Hacking MB, Leaver SK, MacCallum NS, Proudfoot A, Quinlan GJ, Burke-Gaffney A, Evans TWet al., 2008, EXTRACELLULAR THIOREDOXIN IS INCREASED IN PATIENTS WITH SEPSIS: A PROTECTIVE RESPONSE AGAINST RAISED PLASMA LEVELS OF MACROPHAGE MIGRATION INHIBITORY FACTOR?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A70-A70, ISSN: 0040-6376

Conference paper

Pantelidis P, Higgs D, Jagelman TAJ, Quinlan GJ, Lagan AL, Prendergast C, Spagnolo P, Renzoni EA, Abraham DJ, Fonseca C, du Bois RM, Wells AUet al., 2008, ATYPICAL MYCOBACTERIA IN SARCOIDOSIS BRONCHOALVEOLAR LAVAGE CELL PELLETS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A133-A133, ISSN: 0040-6376

Conference paper

Callister ME, Pinhu L, Catley MC, Westwell AD, Newton R, Leaver SK, Quinlan GJ, Evans TW, Griffiths MJ, Burke-Gaffney Aet al., 2008, PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappa B-dependent proinflammatory activation of alveolar epithelial cells, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 155, Pages: 661-672, ISSN: 0007-1188

Journal article

Lagan AL, Quinlan GJ, Mumby S, Melley DD, Goldstraw P, Bellingan GJ, Hill MR, Briggs D, Pantelidis P, du Bois RM, Welsh KI, Evans TWet al., 2008, Variation in iron homeostasis genes between patients with ARDS and healthy control subjects, CHEST, Vol: 133, Pages: 1302-1311, ISSN: 0012-3692

Journal article

Quinlan GJ, Lagan AL, Evans TW, 2008, Haem oxygenase: A model for therapeutic intervention, INTENSIVE CARE MEDICINE, Vol: 34, Pages: 595-597, ISSN: 0342-4642

Journal article

Lagan AL, Melley DD, Evans TW, Quinlan GJet al., 2008, Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 294, Pages: L161-L174, ISSN: 1040-0605

Journal article

MacCallum NS, Gordon SE, Quinlan GJ, Evans TW, Finney SJet al., 2008, Systemic inflammatory response syndrome post cardiac surgery: a useful concept?, Crit Care, International Symposium on Intensive Care and Emergency Medicine, Pages: P258-P258

Conference paper

MacCallum NS, Quinlan GJ, Evans TW, 2007, The role of neutrophil-derived myeloperoxidase in organ dysfunction and sepsis, Intensive Care Medicine: Annual Update 2007, Pages: 173-187, ISBN: 9780387495170

Neutrophils are the first cells to be activated in the host immune response to infection or injury and are critical cellular effectors in both humoral and innate immunity, central to the pathogenesis of sepsis and multi-organ dysfunction [1]. However, the neutrophil capacity for bacterial killing lacks selectivity, despite stringent regulation, and thereby carries the potential to inflict collateral damage to, and destruction of host tissue [2]. Host tissue damage characterizes both autoimmune and inflammatory conditions and may arise via a variety of mechanisms including premature neutrophil activation during migration, extracellular release of cytotoxic molecules during microbial killing, removal of infected or damaged host cells or debris during host tissue remodeling, and failure to terminate acute inflammatory responses [3]. Sepsis-induced neutrophil mediated tissue injury has been demonstrated in a variety of organs including the lungs [4, 5], kidneys [6], and liver [7]. © 2007 Springer Science + Business Media Inc.

Book chapter

MacCallum NS, Gordon SE, Quinlan GJ, Evans TW, Finney SJet al., 2007, The systemic inflammatory response syndrome following cardiac surgery, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 928-928, ISSN: 0009-7322

Conference paper

Melley DD, Finney SJ, Elia A, Lagan AL, Quinlan GJ, Evans TWet al., 2007, Arterial carboxyhemoglobin level and outcome in critically ill patients, CRITICAL CARE MEDICINE, Vol: 35, Pages: 1882-1887, ISSN: 0090-3493

Journal article

Callister ME, Burke-Gaffney A, Quinlan GJ, Betts H, Nadel S, Evans TWet al., 2007, Persistently low plasma thioredoxin is associated with meningococcal septic shock in children, INTENSIVE CARE MEDICINE, Vol: 33, Pages: 364-367, ISSN: 0342-4642

Journal article

Melley DD, Lagan AL, Quinlan GJ, Evans TWet al., 2006, Heme oxygenase-1 is induced in human neutrophils following surgery requiring cardiopulmonary bypass, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II50-II51, ISSN: 0040-6376

Conference paper

Callister ME, Burke-Gaffney A, Quinlan GJ, Nicholson AG, Florio R, Nakamura H, Yodoi J, Evans TWet al., 2006, Extracellular thioredoxin levels are increased in patients with acute lung injury, THORAX, Vol: 61, Pages: 521-527, ISSN: 0040-6376

Journal article

Melley DD, Finney SJ, Quinlan GJ, Evans TWet al., 2006, Arterial Carboxyhemoglobin and Intensive Care Outcome, Am J Respir Crit Care Med, American Thoracic Society International Congress, Pages: A427-A427

Conference paper

Melley DD, Quinlan GJ, Evans TW, 2005, The divergent effects of heme on neutrophil apoptosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II80-II80, ISSN: 0040-6376

Conference paper

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00155872&limit=30&person=true&page=2&respub-action=search.html