Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Senior Research Fellow







B140BGuy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Ramakrishnan, L and Pedersen, S and Toe, Q and Quinlan, GJ and Wort, S},
doi = {10.3389/fphys.2018.00641},
journal = {Frontiers in Physiology},
title = {Pulmonary arterial hypertension: iron matters},
url = {},
volume = {9},
year = {2018}

RIS format (EndNote, RefMan)

AB - The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease. This review provides a background for iron regulation in humans, describes PAH classifications, and discusses emerging literature, which suggests a role for disrupted iron homeostatic control in various sub-types of PAH, including a role for decompartmentalization of hemoglobin. Finally, the potential for therapeutic options to restore iron homeostatic balance in PAH are discussed.
AU - Ramakrishnan,L
AU - Pedersen,S
AU - Toe,Q
AU - Quinlan,GJ
AU - Wort,S
DO - 10.3389/fphys.2018.00641
PY - 2018///
SN - 1664-042X
TI - Pulmonary arterial hypertension: iron matters
T2 - Frontiers in Physiology
UR -
UR -
VL - 9
ER -