Imperial College London

DrGregoryQuinlan

Faculty of MedicineNational Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

g.quinlan

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nikolakopoulou:2019:10.2217/bmm-2018-0238,
author = {Nikolakopoulou, Z and Hector, LR and Creagh-Brown, BC and Evans, T and Quinlan, G and Burke-Gaffney, A},
doi = {10.2217/bmm-2018-0238},
journal = {Biomarkers in Medicine},
pages = {205--218},
title = {Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery},
url = {http://dx.doi.org/10.2217/bmm-2018-0238},
volume = {13},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acutekidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass(CPB). Patients & methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. Results: All markers increased significantly post-CPBwith S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKIwithin 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676–0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivityand 75% specificity) irrespective of age. Conclusion: Plasma S100A8/A9 levels immediately after cardiacsurgery, can predict onset of AKI, irrespective of age.
AU - Nikolakopoulou,Z
AU - Hector,LR
AU - Creagh-Brown,BC
AU - Evans,T
AU - Quinlan,G
AU - Burke-Gaffney,A
DO - 10.2217/bmm-2018-0238
EP - 218
PY - 2019///
SN - 1752-0363
SP - 205
TI - Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery
T2 - Biomarkers in Medicine
UR - http://dx.doi.org/10.2217/bmm-2018-0238
UR - http://hdl.handle.net/10044/1/66739
VL - 13
ER -