Imperial College London

DrGregoryQuinlan

Faculty of MedicineNational Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

g.quinlan

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gutteridge:2020:10.1016/j.bbrc.2019.10.152,
author = {Gutteridge, JMC and Quinlan, GJ and Kovacic, P},
doi = {10.1016/j.bbrc.2019.10.152},
journal = {Biochemical and Biophysical Research Communications},
pages = {721--724},
title = {Phagomimetic action of antibiotics: revisited. How do antibiotics know where to go?},
url = {http://dx.doi.org/10.1016/j.bbrc.2019.10.152},
volume = {521},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event. Antibiotics in their normal bacterial environment, and ROS, are both increasingly implicated in purposeful signalling functions, rather than their more widely known roles in bacterial killing and molecular damage. Here, we extend our comparison between antibiotics and phagocytic cells to propose that antibiotics actively accumulate at a site of pathogen infection or tumour growth. A common link being virulent cellular growth. When this occurs, new proteins are secreted, aberrant iron acquisition takes place, and lipocalins are released. Each provide a mechanism by which antibiotics can bind, and be retained, at an active site of pathogen infection or tumour growth.
AU - Gutteridge,JMC
AU - Quinlan,GJ
AU - Kovacic,P
DO - 10.1016/j.bbrc.2019.10.152
EP - 724
PY - 2020///
SN - 0006-291X
SP - 721
TI - Phagomimetic action of antibiotics: revisited. How do antibiotics know where to go?
T2 - Biochemical and Biophysical Research Communications
UR - http://dx.doi.org/10.1016/j.bbrc.2019.10.152
UR - http://hdl.handle.net/10044/1/74590
VL - 521
ER -