Summary
Dr Gregory Quinlan is a Senior Research Fellow based in the Critical Care, Pulmonary Vascular and Sleep Science Section at the Royal Brompton Campus of the National Heart and Lung Institute (NHLI). He heads the Oxygen Chemistry Group within Critical Care Medicine which is composed of postdoctoral scientists, PhD students and research technicians. He also has an honorary contract with the Royal Brompton Hospital which reflects the translational nature of much of his research.
Dr Quinlan graduated from Thames Polytechnic in 1982 and then worked as a Senior Scientific Officer at the National Institute of Biological Standards and Control for eight years with Professor John MC Gutteridge. During this time research interests were devoted to the investigation of role of oxidative stress and transition metal ions in potential mechanisms of antibiotic action as well as studies on mechanisms of lipid peroxidation. Several of the publications produced during this time have become seminal works. In 1991 Dr Quinlan along with Professor Gutteridge joined the NHLI in order to help establish the then fledgling Critical Care Research group under the leadership of Professor Tim Evans.
Dr Quinlan undertook PhD studies on a part-time basis and was awarded his PhD from the University of London in 1995. Since then Dr Quinlan has remained with the group and is now the principal scientific researcher within the department.
Dr Quinlan has gained an international reputation for innovative research into the pathogenesis of critical illness which together with previous research interests has resulted in over 100 scientific articles. His research efforts as part of Professor Evans group have uniquely contributed to current understanding of the mechanisms involved in the onset and progression of acute lung injury and its severest manifestation the acute respiratory distress syndrome, with particular emphasis on the role of oxidative and nitroasive stress and aberrant iron metabolism. The role haemolysis and the pro-inflammatory action of free haem and haemoglobin in scenarios relevant to acute lung injury and sepsis are areas of particular research interest.
Dr Quinlan is currently supervising five PhD students and has previously supervised seven clinical and non-clinical studentships and fellowships to a successful conclusion.
Along with Dr Mark Griffiths, Dr Quinlan heads a core facility for the Biomedical Research Unit (BRU) at the Royal Brompton Hospital, and is deputy head and scientific lead of the Acute Respiratory Failure Consortium within the BRU.
Dr Quinlan is also a reviewer for the International journal Critical Care Medicine and provides regular manuscript reviews for at least 10 other respiratory and scientific journals, he also provides grant reviews for research councils, medical research charities and foreign governments.
Finally, Dr Quinlan has obtained research funding, from the British Heart Foundation, Wellcome Trust, Dunhill Medical Trust, Henry Smith Charity, JP Moulton Charitable Foundation, the Garfield Weston Trust and the Plasma Protein Therapeutics Association.
Selected Publications
Journal Articles
Ramakrishnan L, Pedersen SL, Toe QK, et al., 2018, The Hepcidin / Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells, Scientific Reports, Vol:8, ISSN:2045-2322
Ramakrishnan L, Pedersen S, Toe Q, et al., 2018, Pulmonary arterial hypertension: iron matters, Frontiers in Physiology, Vol:9, ISSN:1664-042X
Cloonan SM, Mumby S, Adcock IM, et al., 2017, The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease., American Journal of Respiratory and Critical Care Medicine, Vol:196, ISSN:1535-4970
MacCallum NS, Finney SJ, Gordon SE, et al., 2014, Modified criteria for the systemic inflammatory response syndrome improves their utility following cardiac surgery, Chest, Vol:145, ISSN:0012-3692, Pages:1197-1203
Mumby S, Ramakrishnan L, Evans TW, et al., 2014, Methemoglobin-induced signaling and chemokine responses in human alveolar epithelial cells, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol:306, ISSN:1040-0605, Pages:L88-L100
Leaver SK, MacCallum NS, Pingle V, et al., 2010, Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor., Intensive Care Med, Vol:36, ISSN:1432-1238, Pages:336-341
Lagan AL, Quinlan GJ, Mumby S, et al., 2008, Variation in iron homeostasis genes between patients with ARDS and healthy control subjects, Chest, Vol:133, ISSN:0012-3692, Pages:1302-1311
Lagan AL, Melley DD, Evans TW, et al., 2008, Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol:294, ISSN:1040-0605, Pages:L161-L174
Melley DD, Finney SJ, Elia A, et al., 2007, Arterial carboxyhemoglobin level and outcome in critically ill patients, Critical Care Medicine, Vol:35, ISSN:0090-3493, Pages:1882-1887
Callister ME, Burke-Gaffney A, Quinlan GJ, et al., 2006, Extracellular thioredoxin levels are increased in patients with acute lung injury, Thorax, Vol:61, ISSN:0040-6376, Pages:521-527
Quinlan GJ, Martin GS, Evans TW, 2005, Albumin: Biochemical properties and therapeutic potential, Hepatology, Vol:41, ISSN:0270-9139, Pages:1211-1219
Melley DD, Evans TW, Quinlan GJ, 2005, Redox regulation of neutrophil apoptosis and the systemic inflammatory response syndrome, Clinical Science, Vol:108, ISSN:0143-5221, Pages:413-424
Mumby S, Upton RL, Chen Y, et al., 2004, Lung heme oxygenase-1 is elevated in acute respiratory distress syndrome, Critical Care Medicine, Vol:32, ISSN:0090-3493, Pages:1130-1135
Quinlan GJ, Mumby S, Martin GS, et al., 2004, Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury, Critical Care Medicine, Vol:32, ISSN:0090-3493, Pages:755-759
Moloney ED, Mumby SE, Gajdocsi R, et al., 2004, Exhaled breath condensate detects markers of pulmonary inflammation after cardiothoracic surgery, American Journal of Respiratory and Critical Care Medicine, Vol:169, ISSN:1073-449X, Pages:64-69
Sato H, Callister MEJ, Mumby S, et al., 2004, KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome, European Respiratory Journal, Vol:23, ISSN:0903-1936, Pages:142-145
Quinlan GJ, Evans TW, Gutteridge JMC, 2002, Iron and the redox status of the lungs, Free Radical Biology and Medicine, Vol:33, ISSN:0891-5849, Pages:1306-1313
Moran LK, Gutteridge JMC, Quinlan GJ, 2001, Thiols in cellular redox signalling and control, Current Medicinal Chemistry, Vol:8, ISSN:0929-8673, Pages:763-772
Jordan S, Mitchell JA, Quinlan GJ, et al., 2000, The pathogenesis of lung injury following pulmonary resection, European Respiratory Journal, Vol:15, ISSN:0903-1936, Pages:790-799
Lamb NJ, Quinlan GJ, Mumby S, et al., 1999, Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron, Biochemical Journal, Vol:344, ISSN:0264-6021, Pages:153-158
Lamb NJ, Quinlan GJ, Westerman ST, et al., 1999, Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide, American Journal of Respiratory and Critical Care Medicine, Vol:160, ISSN:1073-449X, Pages:1031-1034
Lamb NJ, Gutteridge JMC, Baker C, et al., 1999, Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: Evidence for neutrophil-mediated hydroxylation, nitration, and chlorination, Critical Care Medicine, Vol:27, ISSN:0090-3493, Pages:1738-1744
Anning PB, Chen Y, Lamb NJ, et al., 1999, Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues, FEBS Letters, Vol:447, ISSN:0014-5793, Pages:111-114
Quinlan GJ, Margarson MP, Mumby S, et al., 1998, Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion, Clinical Science, Vol:95, ISSN:0143-5221, Pages:459-465
Williams EA, Quinlan GJ, Goldstraw P, et al., 1998, Postoperative lung injury and oxidative damage in patients undergoing pulmonary resection, European Respiratory Journal, Vol:11, ISSN:0903-1936, Pages:1028-1034
Brett SJ, Quinlan GJ, Mitchell J, et al., 1998, Production of nitric oxide during surgery involving cardiopulmonary bypass, Critical Care Medicine, Vol:26, ISSN:0090-3493, Pages:272-278
Gutteridge JMC, Quinlan GJ, Kovacic P, 1998, Phagomimetic action of antimicrobial agents, Free Radical Research, Vol:28, ISSN:1071-5762, Pages:1-14
Chabot F, Mitchell JA, Quinlan GJ, et al., 1997, Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: Role of poly(adenosine 5'-diphosphoribose) synthase, British Journal of Pharmacology, Vol:121, ISSN:0007-1188, Pages:485-490
Messent M, Sinclair DG, Quinlan GJ, et al., 1997, Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress, Critical Care Medicine, Vol:25, ISSN:0090-3493, Pages:425-429
Quinlan GJ, Lamb NJ, Tilley R, et al., 1997, Plasma hypoxanthine levels in ARDS: Implications for oxidative stress, morbidity, and mortality, American Journal of Respiratory and Critical Care Medicine, Vol:155, ISSN:1073-449X, Pages:479-484
Gutteridge JMC, Mumby S, Quinlan GJ, et al., 1996, Pro-oxidant iron is present in human pulmonary epithelial lining fluid: Implications for oxidative stress in the lung, Biochemical and Biophysical Research Communications, Vol:220, ISSN:0006-291X, Pages:1024-1027
Quinlan GJ, Lamb NJ, Evans TW, et al., 1996, Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome, Critical Care Medicine, Vol:24, ISSN:0090-3493, Pages:241-246
SINCLAIR DG, HASLAM PL, QUINLAN GJ, et al., 1995, THE EFFECT OF CARDIOPULMONARY BYPASS ON INTESTINAL AND PULMONARY ENDOTHELIAL PERMEABILITY, Chest, Vol:108, ISSN:0012-3692, Pages:718-724
GUTTERIDGE JMC, QUINLAN GJ, MUMBY S, et al., 1994, PRIMARY PLASMA ANTIOXIDANTS IN ADULT-RESPIRATORY-DISTRESS-SYNDROME PATIENTS - CHANGES IN IRON-OXIDIZING, IRON-BINDING, AND FREE RADICAL-SCAVENGING PROTEINS, Journal of Laboratory and Clinical Medicine, Vol:124, ISSN:0022-2143, Pages:263-273
GUTTERIDGE JMC, QUINLAN GJ, EVANS TW, 1994, TRANSIENT IRON OVERLOAD WITH BLEOMYCIN DETECTABLE IRON IN THE PLASMA OF PATIENTS WITH ADULT-RESPIRATORY-DISTRESS-SYNDROME, Thorax, Vol:49, ISSN:0040-6376, Pages:707-710
QUINLAN GJ, EVANS TW, GUTTERIDGE JMC, 1994, OXIDATIVE DAMAGE TO PLASMA-PROTEINS IN ADULT-RESPIRATORY-DISTRESS-SYNDROME, Free Radical Research, Vol:20, ISSN:1071-5762, Pages:289-298
QUINLAN GJ, EVANS TW, GUTTERIDGE JMC, 1994, 4-HYDROXY-2-NONENAL LEVELS INCREASE IN THE PLASMA OF PATIENTS WITH ADULT-RESPIRATORY-DISTRESS-SYNDROME AS LINOLEIC-ACID APPEARS TO FALL, Free Radical Research, Vol:21, ISSN:1071-5762, Pages:95-106
MOAT NE, EVANS TE, QUINLAN GJ, et al., 1993, CHELATABLE IRON AND COPPER CAN BE RELEASED FROM EXTRACORPOREALLY CIRCULATED BLOOD DURING CARDIOPULMONARY BYPASS, Febs Letters, Vol:328, ISSN:1873-3468, Pages:103-106
GUTTERIDGE JMC, QUINLAN GJ, 1993, ANTIOXIDANT PROTECTION AGAINST ORGANIC AND INORGANIC OXYGEN RADICALS BY NORMAL HUMAN PLASMA - THE IMPORTANT PRIMARY ROLE FOR IRON-BINDING AND IRON-OXIDIZING PROTEINS, Biochimica et Biophysica Acta, Vol:1156, ISSN:0006-3002, Pages:144-150
REDHEAD K, QUINLAN GJ, DAS RG, et al., 1992, ALUMINUM-ADJUVANTED VACCINES TRANSIENTLY INCREASE ALUMINUM LEVELS IN MURINE BRAIN-TISSUE, Pharmacology & Toxicology, Vol:70, ISSN:0901-9928, Pages:278-280
QUINLAN GJ, GUTTERIDGE JMC, 1991, DNA-BASE DAMAGE BY BETA-LACTAM, TETRACYCLINE, BACITRACIN AND RIFAMYCIN ANTIBACTERIAL ANTIBIOTICS, Biochemical Pharmacology, Vol:42, ISSN:0006-2952, Pages:1595-1599
ARUOMA OI, HALLIWELL B, LAUGHTON MJ, et al., 1989, THE MECHANISM OF INITIATION OF LIPID-PEROXIDATION - EVIDENCE AGAINST A REQUIREMENT FOR AN IRON(II) IRON(III) COMPLEX, Biochemical Journal, Vol:258, ISSN:0264-6021, Pages:617-620
QUINLAN GJ, GUTTERIDGE JMC, 1989, BACITRACIN AND A BACITRACIN-ZINC COMPLEX DAMAGE DNA AND CARBOHYDRATE IN THE PRESENCE OF IRON AND COPPER-SALTS, Free Radical Research Communications, Vol:7, ISSN:8755-0199, Pages:37-44
QUINLAN GJ, HALLIWELL B, MOORHOUSE CP, et al., 1988, ACTION OF LEAD(II) AND ALUMINUM(III) IONS ON IRON-STIMULATED LIPID-PEROXIDATION IN LIPOSOMES, ERYTHROCYTES AND RAT-LIVER MICROSOMAL FRACTIONS, Biochimica et Biophysica Acta, Vol:962, ISSN:0006-3002, Pages:196-200
QUINLAN GJ, GUTTERIDGE JMC, 1988, HYDROXYL RADICAL GENERATION BY THE TETRACYCLINE ANTIBIOTICS WITH FREE-RADICAL DAMAGE TO DNA, LIPIDS AND CARBOHYDRATE IN THE PRESENCE OF IRON AND COPPER-SALTS, Free Radical Biology and Medicine, Vol:5, ISSN:0891-5849, Pages:341-348
QUINLAN GJ, GUTTERIDGE JMC, 1987, OXYGEN RADICAL DAMAGE TO DNA BY RIFAMYCIN-SV AND COPPER IONS, Biochemical Pharmacology, Vol:36, ISSN:0006-2952, Pages:3629-3633
Moorhouse PC, Grootveld M, Halliwell B, et al., 1987, Allopurinol and oxypurinol are hydroxyl radical scavengers., FEBS Letters, Vol:213, ISSN:0014-5793, Pages:23-28
GUTTERIDGE JMC, QUINLAN GJ, CLARK I, et al., 1985, ALUMINUM SALTS ACCELERATE PEROXIDATION OF MEMBRANE-LIPIDS STIMULATED BY IRON SALTS, Biochimica et Biophysica Acta, Vol:835, ISSN:0006-3002, Pages:441-447
GUTTERIDGE JMC, QUINLAN GJ, 1985, FREE-RADICAL DAMAGE TO DEOXYRIBOSE BY ANTHRACYCLINE, AUREOLIC ACID AND AMINOQUINONE ANTITUMOUR ANTIBIOTICS - AN ESSENTIAL REQUIREMENT FOR IRON, SEMIQUINONES AND HYDROGEN-PEROXIDE, Biochemical Pharmacology, Vol:34, ISSN:0006-2952, Pages:4099-4103