Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Senior Research Fellow







B140BGuy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Bastin, AJ and Davies, N and Lim, E and Quinlan, GJ and Griffiths, MJ},
doi = {10.1111/resp.12662},
journal = {Respirology},
pages = {180--187},
title = {Systemic inflammation and oxidative stress post-lung resection: effect of pretreatment with N-acetylcysteine},
url = {},
volume = {21},
year = {2016}

RIS format (EndNote, RefMan)

AB - Background and objectiveN-acetylcysteine has been used to treat a variety of lung diseases, where is it thought to have an antioxidant effect. In a randomized placebo-controlled double-blind study, the effect of N-acetylcysteine on systemic inflammation and oxidative damage was examined in patients undergoing lung resection, a human model of acute lung injury.MethodsEligible adults were randomized to receive preoperative infusion of N-acetylcysteine (240 mg/kg over 12 h) or placebo. Plasma thiols, interleukin-6, 8-isoprostane, ischaemia-modified albumin, red blood cell glutathione and exhaled breath condensate pH were measured pre- and post-operatively as markers of local and systemic inflammation and oxidative stress.ResultsPatients undergoing lung resection and one-lung ventilation exhibited significant postoperative inflammation and oxidative damage. Postoperative plasma thiol concentration was significantly higher in the N-acetylcysteine-treated group. However, there was no significant difference in any of the measured biomarkers of inflammation or oxidative damage, or in clinical outcomes, between N-acetylcysteine and placebo groups.ConclusionPreoperative administration of N-acetylcysteine did not attenuate postoperative systemic or pulmonary inflammation or oxidative damage after lung resection.
AU - Bastin,AJ
AU - Davies,N
AU - Lim,E
AU - Quinlan,GJ
AU - Griffiths,MJ
DO - 10.1111/resp.12662
EP - 187
PY - 2016///
SN - 1440-1843
SP - 180
TI - Systemic inflammation and oxidative stress post-lung resection: effect of pretreatment with N-acetylcysteine
T2 - Respirology
UR -
UR -
UR -
VL - 21
ER -