Publications
173 results found
Lagan AL, Beddow E, Mumby S, et al., 2002, TNF promoter region single nucleotide polymorphism in ARDS, Winter Meeting of the British-Thoracic-Society, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0040-6376
Quinlan GJ, Evans TW, Gutteridge JMC, 2002, Iron and the redox status of the lungs, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 33, Pages: 1306-1313, ISSN: 0891-5849
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- Citations: 42
Festa M, Mumby S, Nadel S, et al., 2002, Antioxidant protection against iron in children with meningococcal sepsis, CRITICAL CARE MEDICINE, Vol: 30, Pages: 1623-1629, ISSN: 0090-3493
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- Citations: 2
Mumby S, Quinlan GJ, Martin GS, et al., 2001, Administration of albumin to patients with ARDS results in improved protection from oxidative damage in plasma, THORAX, Vol: 56, Pages: 10-10, ISSN: 0040-6376
Upton RL, Quinlan GJ, Nicholson AG, et al., 2001, Transferrin receptor expression may be regulated by mechanisms independent of classical IRP regulation in the lungs of patients with ARDS, THORAX, Vol: 56, Pages: 9-9, ISSN: 0040-6376
Moran LK, Gutteridge JMC, Quinlan GJ, 2001, Thiols in cellular redox signalling and control, CURRENT MEDICINAL CHEMISTRY, Vol: 8, Pages: 763-772, ISSN: 0929-8673
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- Citations: 210
Quinlan GJ, Chen Y, Evans TW, et al., 2001, Iron signalling regulated directly and through oxygen: implications for sepsis and the acute respiratory distress syndrome, CLINICAL SCIENCE, Vol: 100, Pages: 169-182, ISSN: 0143-5221
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- Citations: 33
Gutteridge JMC, Quinlan GJ, Evans TW, 2001, The iron paradox of heart and lungs and its implications for acute lung injury, FREE RADICAL RESEARCH, Vol: 34, Pages: 439-443, ISSN: 1071-5762
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- Citations: 11
Mumby S, Quinlan GJ, Evans TW, et al., 2000, Haem oxygenase is elevated in the lungs of patients with ARDS: Implications for iron signalling and accumulation, THORAX, Vol: 55, Pages: A69-A69, ISSN: 0040-6376
Upton RL, Gutteridge JMC, Anning PB, et al., 2000, Ho-1 is involved in the regulation of IRP-1 activity in rat lung: Implications for microbial virulence and lung injury, THORAX, Vol: 55, Pages: A68-A68, ISSN: 0040-6376
Quinlan GJ, Evans TW, 2000, Acute respiratory distress syndrome in adults, HOSPITAL MEDICINE, Vol: 61, Pages: 561-563, ISSN: 1462-3935
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- Citations: 3
Quinlan GJ, Mumby S, Lamb NJ, et al., 2000, Acute respiratory distress syndrome secondary to cardiopulmonary bypass: Do compromised plasma iron-binding antioxidant protection and thiol levels influence outcome?, CRITICAL CARE MEDICINE, Vol: 28, Pages: 2271-2276, ISSN: 0090-3493
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- Citations: 15
Jordan S, Mitchell JA, Quinlan GJ, et al., 2000, The pathogenesis of lung injury following pulmonary resection, EUROPEAN RESPIRATORY JOURNAL, Vol: 15, Pages: 790-799, ISSN: 0903-1936
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- Citations: 165
Chen Y, Quinlan GJ, Anning PB, et al., 1999, Transferrin receptors and ferritin protein levels in heart and lung following LPS treatment, THORAX, Vol: 54, Pages: A13-A13, ISSN: 0040-6376
Mumby S, Moran L, Lamb NJ, et al., 1999, Inducible haem oxygenase is present in bronchoalveolar lavage (BAL) fluid from patients with ARDS: Associations with oxidative stress and free iron, THORAX, Vol: 54, Pages: A80-A80, ISSN: 0040-6376
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- Citations: 1
Lamb NJ, Quinlan GJ, Mumby S, et al., 1999, Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron, BIOCHEMICAL JOURNAL, Vol: 344, Pages: 153-158, ISSN: 0264-6021
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- Citations: 57
Williams EA, Quinlan GJ, Anning PB, et al., 1999, Lung injury following pulmonary resection in the isolated, blood-perfused rat lung, EUROPEAN RESPIRATORY JOURNAL, Vol: 14, Pages: 745-750, ISSN: 0903-1936
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- Citations: 25
Lamb NJ, Quinlan GJ, Westerman ST, et al., 1999, Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 160, Pages: 1031-1034, ISSN: 1073-449X
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- Citations: 64
Lamb NJ, Gutteridge JMC, Baker C, et al., 1999, Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: Evidence for neutrophil-mediated hydroxylation, nitration, and chlorination, CRITICAL CARE MEDICINE, Vol: 27, Pages: 1738-1744, ISSN: 0090-3493
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- Citations: 133
Anning PB, Chen Y, Lamb NJ, et al., 1999, Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues, FEBS LETTERS, Vol: 447, Pages: 111-114, ISSN: 0014-5793
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- Citations: 22
Chen Y, Quinlan GJ, Evans TW, et al., 1999, Expression of transferrin receptor and ferritin mRNA in LPS treated rats: Comparisons between heart and lung, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A245-A245, ISSN: 1073-449X
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- Citations: 2
Anning PB, Quinlan GJ, Williams EA, et al., 1999, Lung injury following pulmonary resection in the isolated blood-perfused rat lung., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A606-A606, ISSN: 1073-449X
Lamb NJ, Quinlan GJ, Evans TW, et al., 1999, Evidence for a pro-oxidant activity of heme oxygenase, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A889-A889, ISSN: 1073-449X
Chen Y, Quinlan GJ, Nicholson A, et al., 1999, Upregulation of inducible heme oxygenase in patients with ARDS: Possible implication for outcome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A377-A377, ISSN: 1073-449X
Anning PB, Chen Y, Lamb NJ, et al., 1999, Iron overloaded rats display a tissue specific, time dependent upregulation of haem oxygenase 1 (HO-1)., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A890-A890, ISSN: 1073-449X
Lamb NJ, Quinlan GJ, Westerman ST, et al., 1999, Increased tyrosine nitration in broncho-alveolar lavage fluid from patients with ARDS receiving inhaled nitric oxide., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A377-A377, ISSN: 1073-449X
Quinlan GJ, Westerman ST, Mumby S, et al., 1999, Plasma hypoxanthine levels during crystalloid and blood cardioplegias: Warm blood cardioplegia increases hypoxanthine levels with a greater risk of oxidative stress, JOURNAL OF CARDIOVASCULAR SURGERY, Vol: 40, Pages: 65-69, ISSN: 0021-9509
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- Citations: 7
Lamb NJ, Quinlan GJ, Westerman ST, et al., 1998, Increased tyrosine nitration in bronchoalveolar lavage fluid from patients with ARDS receiving inhaled nitric oxide, Thorax, Vol: 53, ISSN: 0040-6376
Inhaled nitric oxide (NO) improves oxygenation and reduces pulmonary vascular resistance in a proportion of patients with acute respiratory distress syndrome (ARDS). However, NO is also a free radical that reacts with superoxide to form the highly toxic peroxynitrite (ONOO-) anion. ONOO-, or its decomposition products, can nitrate tyrosine to form 3-nitrotyrosine (3NT), which can be used as a marker of peroxynitrite formation. In this study we measured 3-nitrotyrosine in bronchoalveloar lavage (BAL) samples from 10 patients with ARDS receiving NO, and ten patients with comparable lung injury who were not. BAL samples were collected and spun to remove debris. Following hydrolysis, amino acids were purified by ion-exchange and analysed by high performance liquid chromatography (HPLC). Peaks were identified and quantitated by comparison with known standards. Patients receiving inhaled NO showed significantly increased levels of 3NT in their BAL fluid compared to controls (6.76 ± 2.79 vs 0.4 ± 0.15 nmol/mg of protein, p=0.005). No significant correlation was found between levels of inhaled NO and levels of 3NT measured (r = 0.4), suggesting that levels of NO are not the only factor involved in determining the amount of protein nitration. We have demonstrated an association between the use of inhaled NO in patients with ARDS and increased levels of 3-nitrotyrosine. The significance of the protein nitration observed in these patients remains to be evaluated.
Lamb NJ, Quinlan GJ, Evans TW, et al., 1998, Evidence for a pro-oxidant activity of heme oxygenase, Thorax, Vol: 53, ISSN: 0040-6376
The acute respiratory distress syndrome (ARDS) is known to be associated with increased oxidative stress. Heme oxygenase (HO) catalyses the intracellular breakdown of heme proteins to biliverdin and bilirubin, with the release of carbon monoxide and free iron. HO-1, a heat shock protein (hsp32), is widely induced under conditions of oxidative stress. Much interest has focused on the antioxidant properties of bilirubin. We investigated the fate of the released free iron in a microsomal system, and demonstrate a pro-oxidant capacity of heme oxygenase. Rat liver microsomes were incubated with liposomes, hemoglobin (Hb, substrate), and NADPH. Microsomes and liposomes alone served as a control. We used the TBA test, to measure μM MDA formed as an index of lipid peroxidation (LPO). Various iron chelators, and an antibody to HO-1 were also added as appropriate controls. On addition of substrate there was an increase in lipid peroxidation (see figure). Figure shows HO-mediated peroxidation of liposomes, (where baseline is microsomes (HO) and liposomes, and the reaction is microsomes, liposomes, Hb, and NADPH. Ab; HO-1 polyclonal antibody). LPO was inhibited to baseline levels by SnPP (tin protoporphyrin, a selective inhibitor of HO). The antibody decreased LPO by 36%. BHT and Vit E, both chain-breaking lipid phase antioxidants, inhibited LPO to baseline levels. The iron chelators desferrioxamine (Df) and EDTA also significantly decreased LPO. We have demonstrated that, in a microsomal-lipid system, HO can exert pro-oxidant activity, which is mediated by free iron. The importance of this reaction is under investigation, and may have wider implications in conditions such as ARDS. (Graph Presented).
Quinlan GJ, Margarson MP, Mumby S, et al., 1998, Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion, CLINICAL SCIENCE, Vol: 95, Pages: 459-465, ISSN: 0143-5221
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- Citations: 111
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