Publications
173 results found
MOAT NE, EVANS TE, QUINLAN GJ, et al., 1993, CHELATABLE IRON AND COPPER CAN BE RELEASED FROM EXTRACORPOREALLY CIRCULATED BLOOD DURING CARDIOPULMONARY BYPASS, FEBS LETTERS, Vol: 328, Pages: 103-106, ISSN: 1873-3468
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- Citations: 42
MESSENT M, QUINLAN GJ, GRIFFITHS MJD, et al., 1993, CHARACTERIZATION OF ISCHEMIA/REPERFUSION DAMAGE IN AN ISOLATED-PERFUSED RAT LUNG, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A931-A931, ISSN: 0003-0805
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- Citations: 1
GUTTERIDGE JMC, QUINLAN GJ, 1993, ANTIOXIDANT PROTECTION AGAINST ORGANIC AND INORGANIC OXYGEN RADICALS BY NORMAL HUMAN PLASMA - THE IMPORTANT PRIMARY ROLE FOR IRON-BINDING AND IRON-OXIDIZING PROTEINS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1156, Pages: 144-150, ISSN: 0006-3002
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- Citations: 87
GUTTERIDGE JMC, QUINLAN GJ, 1992, ANTIOXIDANT PROTECTION AGAINST ORGANIC AND INORGANIC OXYGEN RADICALS BY NORMAL HUMAN PLASMA - THE IMPORTANT PRIMARY ROLE FOR IRON-BINDING AND IRON-OXIDIZING PROTEINS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1159, Pages: 248-254, ISSN: 0006-3002
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- Citations: 66
QUINLAN GJ, COUDRAY C, HUBBARD A, et al., 1992, VANADIUM AND COPPER IN CLINICAL SOLUTIONS OF ALBUMIN AND THEIR POTENTIAL TO DAMAGE PROTEIN-STRUCTURE, JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 81, Pages: 611-614, ISSN: 0022-3549
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- Citations: 22
REDHEAD K, QUINLAN GJ, DAS RG, et al., 1992, ALUMINUM-ADJUVANTED VACCINES TRANSIENTLY INCREASE ALUMINUM LEVELS IN MURINE BRAIN-TISSUE, PHARMACOLOGY & TOXICOLOGY, Vol: 70, Pages: 278-280, ISSN: 0901-9928
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- Citations: 27
QUINLAN GJ, GUTTERIDGE JMC, 1991, DNA-BASE DAMAGE BY BETA-LACTAM, TETRACYCLINE, BACITRACIN AND RIFAMYCIN ANTIBACTERIAL ANTIBIOTICS, BIOCHEMICAL PHARMACOLOGY, Vol: 42, Pages: 1595-1599, ISSN: 0006-2952
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- Citations: 28
ARUOMA OI, HALLIWELL B, LAUGHTON MJ, et al., 1989, THE MECHANISM OF INITIATION OF LIPID-PEROXIDATION - EVIDENCE AGAINST A REQUIREMENT FOR AN IRON(II) IRON(III) COMPLEX, BIOCHEMICAL JOURNAL, Vol: 258, Pages: 617-620, ISSN: 0264-6021
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- Citations: 200
QUINLAN GJ, GUTTERIDGE JMC, 1989, BACITRACIN AND A BACITRACIN-ZINC COMPLEX DAMAGE DNA AND CARBOHYDRATE IN THE PRESENCE OF IRON AND COPPER-SALTS, FREE RADICAL RESEARCH COMMUNICATIONS, Vol: 7, Pages: 37-44, ISSN: 8755-0199
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- Citations: 12
QUINLAN GJ, HALLIWELL B, MOORHOUSE CP, et al., 1988, ACTION OF LEAD(II) AND ALUMINUM(III) IONS ON IRON-STIMULATED LIPID-PEROXIDATION IN LIPOSOMES, ERYTHROCYTES AND RAT-LIVER MICROSOMAL FRACTIONS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 962, Pages: 196-200, ISSN: 0006-3002
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- Citations: 228
QUINLAN GJ, GUTTERIDGE JMC, 1988, OXIDATIVE DAMAGE TO DNA AND DEOXYRIBOSE BY BETA-LACTAM ANTIBIOTICS IN THE PRESENCE OF IRON AND COPPER-SALTS, FREE RADICAL RESEARCH COMMUNICATIONS, Vol: 5, Pages: 149-158, ISSN: 8755-0199
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- Citations: 16
QUINLAN GJ, GUTTERIDGE JMC, 1988, HYDROXYL RADICAL GENERATION BY THE TETRACYCLINE ANTIBIOTICS WITH FREE-RADICAL DAMAGE TO DNA, LIPIDS AND CARBOHYDRATE IN THE PRESENCE OF IRON AND COPPER-SALTS, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 5, Pages: 341-348, ISSN: 0891-5849
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- Citations: 52
QUINLAN GJ, GUTTERIDGE JMC, 1987, OXYGEN RADICAL DAMAGE TO DNA BY RIFAMYCIN-SV AND COPPER IONS, BIOCHEMICAL PHARMACOLOGY, Vol: 36, Pages: 3629-3633, ISSN: 0006-2952
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- Citations: 61
Moorhouse PC, Grootveld M, Halliwell B, et al., 1987, Allopurinol and oxypurinol are hydroxyl radical scavengers., FEBS Lett, Vol: 213, Pages: 23-28, ISSN: 0014-5793
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 10(9) M-1 X s-1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k2 approx. 4 X 10(9) M-1 X s-1) and it also reacts with the myeloperoxidase-derived oxidant hypochlorous acid. Hence the protective actions of allopurinol against reperfusion damage after hypoxia need not be entirely due to xanthine oxidase inhibition.
GUTTERIDGE JMC, QUINLAN GJ, 1986, CARMINIC ACID-PROMOTED OXYGEN RADICAL DAMAGE TO LIPID AND CARBOHYDRATE, FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Vol: 3, Pages: 289-293, ISSN: 1944-0049
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- Citations: 10
GUTTERIDGE JMC, BEARD APC, QUINLAN GJ, 1985, CATALASE ENHANCES DAMAGE TO DNA BY BLEOMYCIN-IRON(II) - THE ROLE OF HYDROXYL RADICALS, BIOCHEMISTRY INTERNATIONAL, Vol: 10, Pages: 441-449, ISSN: 0158-5231
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- Citations: 5
GUTTERIDGE JMC, QUINLAN GJ, CLARK I, et al., 1985, ALUMINUM SALTS ACCELERATE PEROXIDATION OF MEMBRANE-LIPIDS STIMULATED BY IRON SALTS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 835, Pages: 441-447, ISSN: 0006-3002
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- Citations: 322
GUTTERIDGE JMC, QUINLAN GJ, 1985, FREE-RADICAL DAMAGE TO DEOXYRIBOSE BY ANTHRACYCLINE, AUREOLIC ACID AND AMINOQUINONE ANTITUMOUR ANTIBIOTICS - AN ESSENTIAL REQUIREMENT FOR IRON, SEMIQUINONES AND HYDROGEN-PEROXIDE, BIOCHEMICAL PHARMACOLOGY, Vol: 34, Pages: 4099-4103, ISSN: 0006-2952
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- Citations: 41
THOMAS AH, QUINLAN GJ, GUTTERIDGE JMC, 1984, ASSAY OF DOXORUBICIN AND 4'-EPIDOXORUBICIN BY REVERSED-PHASE ION-PAIR CHROMATOGRAPHY, JOURNAL OF CHROMATOGRAPHY, Vol: 299, Pages: 489-494, ISSN: 0021-9673
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- Citations: 14
GUTTERIDGE JMC, QUINLAN GJ, WILKINS S, 1984, MITOMYCIN C-INDUCED DEOXYRIBOSE DEGRADATION INHIBITED BY SUPEROXIDE-DISMUTASE - A REACTION INVOLVING IRON, HYDROXYL AND SEMIQUINONE RADICALS, FEBS LETTERS, Vol: 167, Pages: 37-41, ISSN: 0014-5793
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- Citations: 46
Gutteridge JM, Quinlan GJ, 1983, Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators., J Appl Biochem, Vol: 5, Pages: 293-299, ISSN: 0161-7354
Most of the chromogen formed when peroxidized material is heated with thiobarbituric acid (TBA) can be ascribed to a colored complex formed between malondialdehyde (MDA) and TBA. Even when little MDA is present, large amounts of MDA-TBA adduct can be formed. This is because lipid peroxides break down to release MDA during the test conditions. Iron is not essential for the breakdown of the peroxides but is essential for the formation of TBA reactivity. This can be related to the ability of iron to decompose lipid peroxides with the release of peroxy radicals, which are precursors of MDA. These peroxy radicals, when released, can initiate further peroxidation during the heating stage of the TBA test. Fatty acids in the absence of lipid peroxides do not undergo significant peroxidation during the acid-heating stage of the TBA test.
GUTTERIDGE JMC, BEARD APC, QUINLAN GJ, 1983, SUPEROXIDE-DEPENDENT LIPID-PEROXIDATION - PROBLEMS WITH THE USE OF CATALASE AS A SPECIFIC PROBE FOR FENTON-DERIVED HYDROXYL RADICALS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 117, Pages: 901-907, ISSN: 0006-291X
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- Citations: 30
Thomas AH, Pharm B, Newland P, et al., 1981, Identification and determination of the qualitative composition of nystatin using thin-layer chromatography and high-performance liquid chromatography, Journal of Chromatography A, Vol: 216, Pages: 367-373, ISSN: 0021-9673
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- Citations: 18
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