Imperial College London
Alternate

DrGregoryQuinlan

Faculty of Medicine, National Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

g.quinlan

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ramakrishnan:2018:10.3389/fphys.2018.00641,
author = {Ramakrishnan, L and Pedersen, S and Toe, Q and Quinlan, GJ and Wort, S},
doi = {10.3389/fphys.2018.00641},
journal = {Frontiers in Physiology},
title = {Pulmonary arterial hypertension: iron matters},
url = {http://dx.doi.org/10.3389/fphys.2018.00641},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease. This review provides a background for iron regulation in humans, describes PAH classifications, and discusses emerging literature, which suggests a role for disrupted iron homeostatic control in various sub-types of PAH, including a role for decompartmentalization of hemoglobin. Finally, the potential for therapeutic options to restore iron homeostatic balance in PAH are discussed.
AU  - Ramakrishnan,L
AU  - Pedersen,S
AU  - Toe,Q
AU  - Quinlan,GJ
AU  - Wort,S
DO  - 10.3389/fphys.2018.00641
PY  - 2018///
SN  - 1664-042X
TI  - Pulmonary arterial hypertension: iron matters
T2  - Frontiers in Physiology
UR  - http://dx.doi.org/10.3389/fphys.2018.00641
UR  - http://hdl.handle.net/10044/1/60043
VL  - 9
ER  -
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