Imperial College London
Alternate

DrGregoryQuinlan

Faculty of Medicine, National Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

g.quinlan

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Creagh-Brown:2013:2013/496031,
author = {Creagh-Brown, BC and Quinlan, GJ and Hector, LR and Evans, TW and Burke-Gaffney, A},
doi = {2013/496031},
journal = {Mediators of Inflammation},
pages = {1--7},
title = {Association between preoperative plasma sRAGE levels and recovery from cardiac surgery},
url = {http://dx.doi.org/10.1155/2013/496031},
volume = {2013},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and solubleRAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery ofsRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgerynecessitating cardiopulmonary bypass. Methods. Patients ( = 130) undergoing elective cardiac surgery were enrolled prospectively.Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery. Results. Preoperative plasma sRAGEincreased significantly ( < 0.0001) from 1.06 ng/mL (IQR, 0.72–1.76) to 1.93 ng/mL (IQR, 1.14–2.63) 2 h postoperatively. PlasmaS100A8/9 was also significantly ( < 0.0001) higher 2 h postoperatively (2.37 g/mL, IQR, 1.81–3.05) compared to pre-operativelevels (0.41 g/mL, IQR, 0.2–0.65). Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated withduration of critical illness ( = 0.3,  = 0.0007) and length of hospital stay (LOS;  = 0.31,  < 0.0005). Multivariate binarylogistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration ofcritical illness (odds ratio 16.6,  = 0.014) and to be, statistically, the strongest independent predictor of hospital LOS. Conclusion.Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgeryrequiring cardiopulmonary bypass.
AU  - Creagh-Brown,BC
AU  - Quinlan,GJ
AU  - Hector,LR
AU  - Evans,TW
AU  - Burke-Gaffney,A
DO  - 2013/496031
EP  - 7
PY  - 2013///
SN  - 0962-9351
SP  - 1
TI  - Association between preoperative plasma sRAGE levels and recovery from cardiac surgery
T2  - Mediators of Inflammation
UR  - http://dx.doi.org/10.1155/2013/496031
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324425500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.hindawi.com/journals/mi/2013/496031/
UR  - http://hdl.handle.net/10044/1/82062
VL  - 2013
ER  -
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