Imperial College London
Alternate

DrGregoryQuinlan

Faculty of Medicine, National Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

g.quinlan

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cloonan:2017:10.1164/rccm.201702-0311PP,
author = {Cloonan, SM and Mumby, S and Adcock, IM and Choi, AMK and Chung, KF and Quinlan, GJ},
doi = {10.1164/rccm.201702-0311PP},
journal = {American Journal of Respiratory and Critical Care Medicine},
title = {The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.},
url = {http://dx.doi.org/10.1164/rccm.201702-0311PP},
volume = {196},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated with cigarette smoking and is third leading cause of death worldwide. With the recent emergence of genome wide association studies (GWAS), the identification of multiple COPD susceptibility genes has enhanced and expanded our understanding of the pathogenic mechanisms associated with this debilitating lung disease. An example of such a pathogenic mechanism is the role of iron metabolism in the onset and progression of COPD. Historic observations of iron dysregulation in COPD can now be enlightened by the recent revelations that genetic polymorphisms in the gene iron regulatory protein-2 (IRP-2) associate with COPD susceptibility. A functional role for IRP-2 is supported by IRP-2 overexpression in murine models, that demonstrates cellular and mitochondrial iron accumulation in the lung linked with manifestations of experimental COPD. Increased IRP2 may explain the excessive iron deposition in alveolar macrophages and tissue in smokers and in patients with COPD. Changes in IRP2 expression may also associate with systemic iron mismanagement, which may explain the prevalence of systemic iron deficiency and iron-deficiency anemia in patients with COPD. It may also help to explain why patients with COPD and/or iron deficiency manifest altered responses to hypoxia including erythropoiesis and pulmonary hypertension. We provide a concise review of the role of iron in the pathogenesis, susceptibility and progression of COPD and highlight the prospective therapeutic interventions for treating both local and systemic iron dysregulation.
AU  - Cloonan,SM
AU  - Mumby,S
AU  - Adcock,IM
AU  - Choi,AMK
AU  - Chung,KF
AU  - Quinlan,GJ
DO  - 10.1164/rccm.201702-0311PP
PY  - 2017///
SN  - 1535-4970
TI  - The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201702-0311PP
UR  - http://hdl.handle.net/10044/1/48289
VL  - 196
ER  -
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