Job Title: Professor of Cell Biology and Functional Genomics
Research: Signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.
Brief Biosketch: After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca2 signalling, I subsequently worked on the pancreatic β-cell as an MRC travelling Fellow with Claes Wollheim in Geneva. There, working collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua, I established new approaches to exploring the control of insulin release at the single cell level through the use of recombinant target probes and other techniques. I then returned to Bristol, becoming a full Professor of Biochemistry in 2002, and moved to Imperial College in 2006.
My current research is supported by Wellcome Trust Senior Investigator and Royal Society Wolfson Merit Awards, by UK Research Council and Diabetes UK grants, as well as by the European Commission Innovative Medicines Initiative in Diabetes (IMIDIA).
Prizes and Awards: I was awarded the Minkowski Prize of the European Association for the Study of Diabetes in 2004, the Juvenile Diabetes Research Foundation's Mary Jane Krugel Award (2005), a Royal Society Wolfson Research Merit Award (2011), a Wellcome Trust Senior Investigator Award (2012) and the Dorothy Hodgkin Lecturehip of Diabetes UK (2014).
Research Support. Supported by Programme and other grants from the Wellcome Trust, MRC, DUK, JDRF, BBSRC, NIH, BHF and EU.
Related links to Section of Cell Biology and Functional Genomics
et al., 2024, Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity, Diabetologia, ISSN:0012-186X
et al., 2023, Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells., Biorxiv
et al., 2023, A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions., Biorxiv
et al., 2023, Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy, Embo Molecular Medicine, Vol:15, ISSN:1757-4676
et al., 2023, AN UNSUPERVISED APPROACH TO SYSTEMATICALLY ANALYSIS THE MULTI-OMICS PROFILES ASSOCIATED WITH T2D INSULIN RESISTANCE AND BETA-CELL FUNCTION: AN EU-RHAPSODY STUDY, Canadian Journal of Diabetes, Vol:47, ISSN:1499-2671, Pages:S142-S142