Imperial College London

ProfessorGuyRutter

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Chair in Cell Biology and Head of Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Assistant

 

Ms Shazi Singh +44 (0)20 7594 3391

 
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Location

 

327ICTEM buildingHammersmith Campus

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Summary

 

Summary

Job Title: Professor and Head of Section of Cell Biology and Functional Genomics

Research: Signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.

Brief Biosketch: After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca2+ signalling, I subsequently worked on the pancreatic β-cell as an MRC travelling Fellow with Claes Wollheim in Geneva. There, working collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua, I established new approaches to exploring the control of insulin release at the single cell level through the use of recombinant target probes and other techniques. I then returned to Bristol, becoming a full Professor of Biochemistry in 2002, and moved to Imperial College in 2006.  

My current research is supported by Wellcome Trust Senior Investigator and Royal Society Wolfson Merit Awards, by UK Research Council and Diabetes UK grants, as well as by the European Commission Innovative Medicines Initiative in Diabetes (IMIDIA).

Prizes and Awards: I was awarded the Minkowski Prize of the European Association for the Study of Diabetes in 2004, the Juvenile Diabetes Research Foundation's Mary Jane Krugel Award (2005), a Royal Society Wolfson Research Merit Award (2011), a Wellcome Trust Senior Investigator Award (2012) and the Dorothy Hodgkin Lecturehip of Diabetes UK (2014).

Recent Publications

Research Support. Supported by Programme and other grants from the Wellcome Trust, MRC, DUK, JDRF, BBSRC, NIH, BHF and EU.

Related links to Section of Cell Biology and Functional Genomics and Imperial Beta Cell Consortium

Publications

Journals

Carrat GR, Haythorne E, Tomas A, et al., 2020, The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis, Molecular Metabolism, Vol:40, ISSN:2212-8778

Rutter GA, Georgiadou E, Martinez-Sanchez A, et al., 2020, Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity, Diabetologia, Vol:63, ISSN:0012-186X, Pages:1990-1998

Mao D, Tian XY, Mao D, et al., 2020, A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-κB pathway and IL-1β-induced islet inflammation and increases insulin secretion., J Biol Chem, Vol:295, Pages:12573-12587

Rutter GA, Ninov N, Salem V, et al., 2020, Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836, Diabetes, Vol:69, ISSN:0012-1797, Pages:E10-E11

Conference

Akalestou E, Suba K, Lopez-Noriega L, et al., 2020, Metabolic surgery recovers Ca(2+)dynamics across pancreatic islets in obese mice, 56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SPRINGER, Pages:S114-S114, ISSN:0012-186X

More Publications