Imperial College London

ProfessorGuyRutter

Faculty of MedicineDepartment of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Summary

Job Title: Professor of Cell Biology and Functional Genomics

Research: Signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.

Brief Biosketch: After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca2 signalling, I subsequently worked on the pancreatic β-cell as an MRC travelling Fellow with Claes Wollheim in Geneva. There, working collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua, I established new approaches to exploring the control of insulin release at the single cell level through the use of recombinant target probes and other techniques. I then returned to Bristol, becoming a full Professor of Biochemistry in 2002, and moved to Imperial College in 2006.  

My current research is supported by Wellcome Trust Senior Investigator and Royal Society Wolfson Merit Awards, by UK Research Council and Diabetes UK grants, as well as by the European Commission Innovative Medicines Initiative in Diabetes (IMIDIA).

Prizes and Awards: I was awarded the Minkowski Prize of the European Association for the Study of Diabetes in 2004, the Juvenile Diabetes Research Foundation's Mary Jane Krugel Award (2005), a Royal Society Wolfson Research Merit Award (2011), a Wellcome Trust Senior Investigator Award (2012) and the Dorothy Hodgkin Lecturehip of Diabetes UK (2014).

Recent Publications

Research Support. Supported by Programme and other grants from the Wellcome Trust, MRC, DUK, JDRF, BBSRC, NIH, BHF and EU.

Related links to Section of Cell Biology and Functional Genomics

Publications

Journals

Yu V, Yong F, Marta A, et al., 2024, Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity, Diabetologia, Vol:67, ISSN:0012-186X, Pages:1079-1094

Slieker RC, Münch M, Donnelly LA, et al., 2024, An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study, Diabetologia, Vol:67, ISSN:0012-186X, Pages:885-894

Hu M, Kim I, Morán I, et al., 2024, Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function., Faseb J, Vol:38

Suba K, Patel Y, Alonso-Martin A, et al., 2024, Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homeostasis, Molecular Metabolism, ISSN:2212-8778

Cuozzo F, Viloria K, Shilleh AH, et al., 2024, LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells, Cell Reports, Vol:43, ISSN:2211-1247

More Publications