Publications
674 results found
Nicholls LI, Ainscow EK, Rutter GA, 2002, Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: Impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 291, Pages: 1081-1088, ISSN: 0006-291X
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- Citations: 20
Palmer DG, Rutter GA, Tavaré JM, 2002, Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 291, Pages: 439-443, ISSN: 0006-291X
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- Citations: 30
Ainscow EK, Rutter GA, 2002, Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet β-cells -: Evidence for a Ca<SUP>2+</SUP>-dependent mechanism, DIABETES, Vol: 51, Pages: S162-S170, ISSN: 0012-1797
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- Citations: 111
Varadi A, Rutter GA, 2002, Dynamic imaging of endoplasmic reticulum Ca<SUP>2+</SUP> concentration in insulin-secreting MIN6 cells using recombinant targeted cameleons -: Roles of sarco(endo)plasmic reticulum Ca<SUP>2+</SUP>-ATPase (SERCA)-2 and ryanodine receptors, DIABETES, Vol: 51, Pages: S190-S201, ISSN: 0012-1797
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- Citations: 73
Leclerc I, da Silva Xavier G, Rutter GA, 2002, AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?, Prog Nucleic Acid Res Mol Biol., Vol: 71, Pages: 69-90
Váradi A, Rutter GA, 2002, Green fluorescent protein calcium biosensors. Calcium imaging with GFP cameleons., Methods Mol Biol, Vol: 183, Pages: 255-264, ISSN: 1064-3745
Rutter GA, 2001, Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances., Mol Aspects Med, Vol: 22, Pages: 247-284, ISSN: 0098-2997
Insulin secretion from pancreatic islet beta-cells is a tightly regulated process, under the close control of blood glucose concentrations, and several hormones and neurotransmitters. Defects in glucose-triggered insulin secretion are ultimately responsible for the development of type II diabetes, a condition in which the total beta-cell mass is essentially unaltered, but beta-cells become progressively "glucose blind" and unable to meet the enhanced demand for insulin resulting for peripheral insulin resistance. At present, the mechanisms by which glucose (and other nutrients including certain amino acids) trigger insulin secretion in healthy individuals are understood only in part. It is clear, however, that the metabolism of nutrients, and the generation of intracellular signalling molecules including the products of mitochondrial metabolism, probably play a central role. Closure of ATP-sensitive K+(K(ATP)) channels in the plasma membrane, cell depolarisation, and influx of intracellular Ca2+, then prompt the "first phase" on insulin release. However, recent data indicate that glucose also enhances insulin secretion through mechanisms which do not involve a change in K(ATP) channel activity, and seem likely to underlie the second, sustained phase of glucose-stimulated insulin secretion. In this review, I will discuss recent advances in our understanding of each of these signalling processes.
Mitchell KJ, Pinton P, Varadi A, et al., 2001, Dense core secretory vesicles revealed as a dynamic Ca<SUP>2+</SUP> store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera, JOURNAL OF CELL BIOLOGY, Vol: 155, Pages: 41-51, ISSN: 0021-9525
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- Citations: 164
Mitchell K, Varadi A, Ainscow E, et al., 2001, In vivo imaging of ryanodine receptor-mediated calcium release from dense core secretary vesicles in insulin secreting cells, DIABETOLOGIA, Vol: 44, Pages: A133-A133, ISSN: 0012-186X
Renström E, Barg S, Galvanovskis J, et al., 2001, Cyclic AMP stimulates insulin exocytosis by modification of granules already present at the release sites, DIABETOLOGIA, Vol: 44, Pages: A62-A62, ISSN: 0012-186X
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- Citations: 1
Ainscow EK, Mirshamsi S, Ashford MLJ, et al., 2001, Distinct responses to glucose of free ATP concentration imaged dynamically in hypothalamic neurones and glial cells., DIABETOLOGIA, Vol: 44, Pages: A169-A169, ISSN: 0012-186X
Andreolas C, Zhao C, Xavier GD, et al., 2001, Sterol regulatory element binding protein 1c (SREBP-1c) is regulated by glucose at the transcriptional level in MIN6 β cell line., DIABETOLOGIA, Vol: 44, Pages: A31-A31, ISSN: 0012-186X
Leclerc I, Lenzner C, Gourdon L, et al., 2001, Hepatocyte nuclear factor-4α involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase, DIABETES, Vol: 50, Pages: 1515-1521, ISSN: 0012-1797
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- Citations: 134
Zhao C, Wilson MC, Schuit F, et al., 2001, Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas, DIABETES, Vol: 50, Pages: 361-366, ISSN: 0012-1797
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- Citations: 119
Ainscow EK, Rutter GA, 2001, Mitochondrial priming modifies Ca<SUP>2+</SUP> oscillations and insulin secretion in pancreatic islets, BIOCHEMICAL JOURNAL, Vol: 353, Pages: 175-180, ISSN: 0264-6021
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- Citations: 78
Porcelli AM, Pinton P, Ainscow EK, et al., 2001, Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH, METHODS IN CELL BIOLOGY, VOL 65, Vol: 65, Pages: 353-+, ISSN: 0091-679X
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- Citations: 25
Porcelli AM, Pinton P, Ainscow EK, et al., 2001, Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH., Methods Cell Biol, Vol: 65, Pages: 353-380, ISSN: 0091-679X
da Silva Xavier G, Varadi A, Ainscow EK, et al., 2000, Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase, J Biol Chem, Vol: 275, Pages: 36269-36277
Rutter GA, 2000, Diabetes: The importance of the liver, CURRENT BIOLOGY, Vol: 10, Pages: R736-R738, ISSN: 0960-9822
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- Citations: 28
Tsuboi T, Zhao C, Terakawa S, et al., 2000, Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event, CURRENT BIOLOGY, Vol: 10, Pages: 1307-1310, ISSN: 0960-9822
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- Citations: 118
Xavier GD, Rutter GA, 2000, Role of insulin release in the stimulation by glucose of the L-type pyruvate kinase gene in single MIN6 β cells., DIABETOLOGIA, Vol: 43, Pages: A120-A120, ISSN: 0012-186X
Nicholls LI, Ainscow EK, Rutter GA, 2000, Effects of manipulation of pyruvate dehydrogenase (PDH) activity in MIN6 cells using recombinant PDH phosphatase (PDP) and PDH kinase (PDK)., DIABETOLOGIA, Vol: 43, Pages: A43-A43, ISSN: 0012-186X
Varadi A, Rutter GA, 2000, Imaging Ca<SUP>2+</SUP> concentration changes in the endoplasmic reticulum of single β-cells with targeted cameleons., DIABETOLOGIA, Vol: 43, Pages: A11-A11, ISSN: 0012-186X
Ainscow EK, Rutter GA, 2000, Elevated mitochondrial [Ca<SUP>2+</SUP>] provokes a long-lived potentiation of glucose metabolism in islet β-cells., DIABETOLOGIA, Vol: 43, Pages: A44-A44, ISSN: 0012-186X
Mitchell K, Jones A, Varadi A, et al., 2000, Imaging Ca<SUP>2+</SUP> concentration changes in the matrix of secretory vesicles in insulin secreting cells, DIABETOLOGIA, Vol: 43, Pages: A118-A118, ISSN: 0012-186X
Ainscow EK, Zhao C, Rutter GA, 2000, Acute overexpression of lactate dehydrogenase-A perturbs β-cell mitochondrial metabolism and insulin secretion, DIABETES, Vol: 49, Pages: 1149-1155, ISSN: 0012-1797
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- Citations: 140
Locker JK, Kuehn A, Schleich S, et al., 2000, Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV, MOLECULAR BIOLOGY OF THE CELL, Vol: 11, Pages: 2497-2511, ISSN: 1059-1524
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- Citations: 141
Rutter CA, Tavaré JM, Palmer DG, 2000, Regulation of mammalian gene expression by glucose, NEWS IN PHYSIOLOGICAL SCIENCES, Vol: 15, Pages: 149-154, ISSN: 0886-1714
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- Citations: 22
Rutter GA, Rizzuto R, 2000, Regulation of mitochondrial metabolism by ER Ca<SUP>2+</SUP> release:: an intimate connection, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 25, Pages: 215-221, ISSN: 0968-0004
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- Citations: 175
Rafiq I, da Silva Xavier G, Hooper S, et al., 2000, Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2., J Biol Chem, Vol: 275, Pages: 15977-15984
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