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@article{Akalestou:2020:10.3389/fendo.2020.00059,
author = {Akalestou, E and Genser, L and Rutter, GA},
doi = {10.3389/fendo.2020.00059},
journal = {Frontiers in Endocrinology},
title = {Glucocorticoid metabolism in obesity and following weight loss},
url = {http://dx.doi.org/10.3389/fendo.2020.00059},
volume = {11},
year = {2020}
}

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TY  - JOUR
AB  - Glucocorticoids are steroid hormones produced by the adrenal cortex and are essential for the maintenance of various metabolicand homeostatic functions. Their function is regulated at the tissue level by 11βhydroxysteroid dehydrogenases and they signalthrough the glucocorticoid receptor, a ligand-dependent transcription factor. Clinical observations have linked excess glucocorticoidlevels with profound metabolic disturbances of intermediate metabolism resulting in abdominal obesity, insulin resistance anddyslipidaemia. In this review, we discuss the physiological mechanisms of glucocorticoid secretion, regulation and function, andsurvey the metabolic consequences of excess glucocorticoid action resulting from elevated release and activation or up-regulatedsignalling. Finally, we summarise the reported impact of weight loss by diet, exercise or bariatric surgery on circulating andtissue-specific glucocorticoid levels and examine the therapeutic possibility of reversing glucocorticoid-associated metabolicdisorders.
AU  - Akalestou,E
AU  - Genser,L
AU  - Rutter,GA
DO  - 10.3389/fendo.2020.00059
PY  - 2020///
SN  - 1664-2392
TI  - Glucocorticoid metabolism in obesity and following weight loss
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2020.00059
UR  - http://hdl.handle.net/10044/1/77381
VL  - 11
ER  -

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