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@article{Ma:2020:10.1172/jci.insight.132760,
author = {Ma, Y and Ratnasabapathy, R and De, Backer I and Izzi-Engbeaya, C and Nguyen-Tu, M-S and Cuenco, J and Jones, B and John, C and Lam, B and Rutter, G and Yeo, G and Dhillo, W and Gardiner, J},
doi = {10.1172/jci.insight.132760},
journal = {JCI insight},
title = {Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release},
url = {http://dx.doi.org/10.1172/jci.insight.132760},
volume = {5},
year = {2020}
}

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TY  - JOUR
AB  - Glucokinase (GK) is highly expressed in the hypothalamic paraventricular nucleus (PVN); however, its role is currently unknown. We found that GK in the PVN acts as part of a glucose-sensing mechanism within the PVN that regulates glucose homeostasis by controlling glucagon-like peptide 1 (GLP-1) release. GLP-1 is released from enteroendocrine L cells in response to oral glucose. Here we identify a brain mechanism critical to the release of GLP-1 in response to oral glucose. We show that increasing expression of GK or injection of glucose into the PVN increases GLP-1 release in response to oral glucose. On the contrary, decreasing expression of GK or injection of nonmetabolizable glucose into the PVN prevents GLP-1 release. Our results demonstrate that gluco-sensitive GK neurons in the PVN are critical to the response to oral glucose and subsequent release of GLP-1.
AU  - Ma,Y
AU  - Ratnasabapathy,R
AU  - De,Backer I
AU  - Izzi-Engbeaya,C
AU  - Nguyen-Tu,M-S
AU  - Cuenco,J
AU  - Jones,B
AU  - John,C
AU  - Lam,B
AU  - Rutter,G
AU  - Yeo,G
AU  - Dhillo,W
AU  - Gardiner,J
DO  - 10.1172/jci.insight.132760
PY  - 2020///
SN  - 2379-3708
TI  - Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release
T2  - JCI insight
UR  - http://dx.doi.org/10.1172/jci.insight.132760
UR  - http://hdl.handle.net/10044/1/79031
VL  - 5
ER  -

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