Imperial College London
Alternate

ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
//

Location

 

ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hu:2020:10.3389/fendo.2020.576632,
author = {Hu, M and Cherkaoui, I and Misra, S and Rutter, GA},
doi = {10.3389/fendo.2020.576632},
journal = {Front Endocrinol (Lausanne)},
pages = {1--20},
title = {Functional genomics in pancreatic β cells: recent advances in gene deletion and genome editing technologies for diabetes research.},
url = {http://dx.doi.org/10.3389/fendo.2020.576632},
volume = {11},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The inheritance of variants that lead to coding changes in, or the mis-expression of, genes critical to pancreatic beta cell function can lead to alterations in insulin secretion and increase the risk of both type 1 and type 2 diabetes. Recently developed clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) gene editing tools provide a powerful means of understanding the impact of identified variants on cell function, growth, and survival and might ultimately provide a means, most likely after the transplantation of genetically "corrected" cells, of treating the disease. Here, we review some of the disease-associated genes and variants whose roles have been probed up to now. Next, we survey recent exciting developments in CRISPR/Cas9 technology and their possible exploitation for β cell functional genomics. Finally, we will provide a perspective as to how CRISPR/Cas9 technology may find clinical application in patients with diabetes.
AU  - Hu,M
AU  - Cherkaoui,I
AU  - Misra,S
AU  - Rutter,GA
DO  - 10.3389/fendo.2020.576632
EP  - 20
PY  - 2020///
SN  - 1664-2392
SP  - 1
TI  - Functional genomics in pancreatic β cells: recent advances in gene deletion and genome editing technologies for diabetes research.
T2  - Front Endocrinol (Lausanne)
UR  - http://dx.doi.org/10.3389/fendo.2020.576632
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33162936
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2020.576632/full
UR  - http://hdl.handle.net/10044/1/84092
VL  - 11
ER  -
Download