Imperial College London
Alternate

ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chabosseau:2021:10.3390/ijms22031000,
author = {Chabosseau, P and Rutter, G and Millership, S},
doi = {10.3390/ijms22031000},
journal = {International Journal of Molecular Sciences},
title = {Importance of both imprinted genes and functional  heterogeneity in pancreatic beta cells: is there a link?},
url = {http://dx.doi.org/10.3390/ijms22031000},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Diabetes mellitus now affects more than 400 million individuals worldwide, with significant impacts on the lives of those affected and associated socio-economic costs. Although defects in insulin secretion underlie all forms of the disease, the molecular mechanisms which drive them are still poorly understood. Subsets of specialised beta cells have, in recent years, been suggested to play critical roles in “pacing” overall islet activity. The molecular nature of these cells, the means through which their identity is established and the changes which may contribute to their functional demise and “loss of influence” in both type 1 and type 2 diabetes are largely unknown. Genomic imprinting involves the selective silencing of one of the two parental alleles through DNA methylation and modified imprinted gene expression is involved in a number of diseases. Loss of expression, or loss of imprinting, can be shown in mouse models to lead to defects in beta cell function and abnormal insulin secretion. In the present review we survey the evidence that altered expression of imprinted genes contribute to loss of beta cell function, the importance of beta cell heterogeneity in normal and disease states, and hypothesise whether there is a direct link between the two.
AU  - Chabosseau,P
AU  - Rutter,G
AU  - Millership,S
DO  - 10.3390/ijms22031000
PY  - 2021///
SN  - 1422-0067
TI  - Importance of both imprinted genes and functional  heterogeneity in pancreatic beta cells: is there a link?
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms22031000
UR  - http://hdl.handle.net/10044/1/86898
VL  - 22
ER  -
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