Imperial College London
Alternate

ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3340g.rutter Website

 
 
//

Location

 

ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cruciani-Guglielmacci:2022:10.3390/cells11111737,
author = {Cruciani-Guglielmacci, C and Meneyrol, K and Denom, J and Kassis, N and Rachdi, L and Makaci, F and Migrenne-Li, S and Daubigney, F and Georgiadou, E and Denis, RG and Rodriguez, Sanchez-Archidona A and Paul, J-L and Thorens, B and Rutter, GA and Magnan, C and Le, Stunff H and Janel, N},
doi = {10.3390/cells11111737},
journal = {Cells},
title = {Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse},
url = {http://dx.doi.org/10.3390/cells11111737},
volume = {11},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the link between CBS activity and the setting of type 2 diabetes is still unknown. We aimed to decipher the consequences of an inborn defect in CBS on glucose homeostasis in mice. We used a mouse model heterozygous for CBS (CBS+/-) that presented a mild HHcy. Other groups were supplemented with methionine in drinking water to increase the mild to intermediate HHcy, and were submitted to a high-fat diet (HFD). We measured the food intake, body weight gain, body composition, glucose homeostasis, plasma homocysteine level, and CBS activity. We evidenced a defect in the stimulated insulin secretion in CBS+/- mice with mild and intermediate HHcy, while mice with intermediate HHcy under HFD presented an improvement in insulin sensitivity that compensated for the decreased insulin secretion and permitted them to maintain a glucose tolerance similar to the CBS+/+ mice. Islets isolated from CBS+/- mice maintained their ability to respond to the elevated glucose levels, and we showed that a lower parasympathetic tone could, at least in part, be responsible for the insulin secretion defect. Our results emphasize the important role of Hcy metabolic enzymes in insulin secretion and overall glucose homeostasis.
AU  - Cruciani-Guglielmacci,C
AU  - Meneyrol,K
AU  - Denom,J
AU  - Kassis,N
AU  - Rachdi,L
AU  - Makaci,F
AU  - Migrenne-Li,S
AU  - Daubigney,F
AU  - Georgiadou,E
AU  - Denis,RG
AU  - Rodriguez,Sanchez-Archidona A
AU  - Paul,J-L
AU  - Thorens,B
AU  - Rutter,GA
AU  - Magnan,C
AU  - Le,Stunff H
AU  - Janel,N
DO  - 10.3390/cells11111737
PY  - 2022///
SN  - 2073-4409
TI  - Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse
T2  - Cells
UR  - http://dx.doi.org/10.3390/cells11111737
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35681432
UR  - http://hdl.handle.net/10044/1/97631
VL  - 11
ER  -
Download