Publications

BibTex format

@article{Slieker:2023:10.1038/s41467-023-38148-7,
author = {Slieker, R and Donnellly, L and Akalestou, E and Lopez-Noriega, L and Melhem, R and Gunes, A and Abou, Azar F and Efanov, A and Georgiadou, E and Muniangi-Muhitu, H and Shiekh, M and Giordano, G and Åkerlund, M and Ahlqvist, E and Ashfaq, A and Banasik, K and Brunak, S and Barovic, M and Bouland, G and Burdet, F and Canouil, M and Dragan, I and Elders, P and Fernandez, C and Festa, A and Fitipaldi, H and Froguel, P and Gudmundsdottir, V and Gudnason, V and Gerl, M and van, der Heijden A and Jennings, L and Hansen, M and Kim, M and Leclerc, I and Klose, C and Kuznetsov, D and Mansour, Aly D and Mehl, F and Marek, D and Melander, O and Niknejad, A and Ottosson, F and Pavo, I and Duffin, K and Syed, S and Shaw, J and Cabrera, O and Pullen, T and Simons, K and Solimena, M and Suvitaival, T and Wretlind, A and Rossing, P and Lyssenko, V and Legido, Quigley C and Groop, L and Thorens, B and Franks, P and Lim, G and Estall, J and Ibberson, M and Beulens, J and t, Hart L and Pearson, E and Rut},
doi = {10.1038/s41467-023-38148-7},
journal = {Nature Communications},
pages = {1--18},
title = {Identification of biomarkers for glycaemic deterioration in type 2 diabetes},
url = {http://dx.doi.org/10.1038/s41467-023-38148-7},
volume = {14},
year = {2023}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two cohorts, levels of GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 are associated with faster progression, whilst SMAC/DIABLO, SPOCK1 and HEMK2 predict lower progression rates. In an external replication, proteins and lipids are associated with diabetes incidence and prevalence. NogoR/RTN4R injection improved glucose tolerance in high fat-fed male mice but impaired it in male db/db mice. High NogoR levels led to islet cell apoptosis, and IL-18R antagonised inflammatory IL-18 signalling towards nuclear factor kappa-B in vitro. This comprehensive, multi-disciplinary approach thus identifies biomarkers with potential prognostic utility, provides evidence for possible disease mechanisms, and identifies potential therapeutic avenues to slow diabetes progression.
AU  - Slieker,R
AU  - Donnellly,L
AU  - Akalestou,E
AU  - Lopez-Noriega,L
AU  - Melhem,R
AU  - Gunes,A
AU  - Abou,Azar F
AU  - Efanov,A
AU  - Georgiadou,E
AU  - Muniangi-Muhitu,H
AU  - Shiekh,M
AU  - Giordano,G
AU  - Åkerlund,M
AU  - Ahlqvist,E
AU  - Ashfaq,A
AU  - Banasik,K
AU  - Brunak,S
AU  - Barovic,M
AU  - Bouland,G
AU  - Burdet,F
AU  - Canouil,M
AU  - Dragan,I
AU  - Elders,P
AU  - Fernandez,C
AU  - Festa,A
AU  - Fitipaldi,H
AU  - Froguel,P
AU  - Gudmundsdottir,V
AU  - Gudnason,V
AU  - Gerl,M
AU  - van,der Heijden A
AU  - Jennings,L
AU  - Hansen,M
AU  - Kim,M
AU  - Leclerc,I
AU  - Klose,C
AU  - Kuznetsov,D
AU  - Mansour,Aly D
AU  - Mehl,F
AU  - Marek,D
AU  - Melander,O
AU  - Niknejad,A
AU  - Ottosson,F
AU  - Pavo,I
AU  - Duffin,K
AU  - Syed,S
AU  - Shaw,J
AU  - Cabrera,O
AU  - Pullen,T
AU  - Simons,K
AU  - Solimena,M
AU  - Suvitaival,T
AU  - Wretlind,A
AU  - Rossing,P
AU  - Lyssenko,V
AU  - Legido,Quigley C
AU  - Groop,L
AU  - Thorens,B
AU  - Franks,P
AU  - Lim,G
AU  - Estall,J
AU  - Ibberson,M
AU  - Beulens,J
AU  - t,Hart L
AU  - Pearson,E
AU  - Rutter,G
DO  - 10.1038/s41467-023-38148-7
EP  - 18
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Identification of biomarkers for glycaemic deterioration in type 2 diabetes
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-38148-7
UR  - https://www.nature.com/articles/s41467-023-38148-7
UR  - http://hdl.handle.net/10044/1/103967
VL  - 14
ER  -

Download

ProfessorGuyRutter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)