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BibTex format

@article{Walker:2017:10.1017/erm.2017.7,
author = {Walker, BJ and stan, GB and Polizzi, KM},
doi = {10.1017/erm.2017.7},
journal = {Expert Reviews in Molecular Medicine},
title = {Intracellular delivery of biologic therapeutics by bacterial secretion systems},
url = {http://dx.doi.org/10.1017/erm.2017.7},
volume = {19},
year = {2017}
}

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TY  - JOUR
AB  - Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potential solution: bacterial nanomachines that have evolved over millions of years to efficiently deliver proteins and nucleic acids across cell membranes and between cells. In this review, we provide a brief overview of the different bacterial systems capable of direct delivery into the eukaryotic cytoplasm and the medical applications for which they are being investigated, along with a perspective on the future directions of this exciting field.
AU  - Walker,BJ
AU  - stan,GB
AU  - Polizzi,KM
DO  - 10.1017/erm.2017.7
PY  - 2017///
SN  - 1462-3994
TI  - Intracellular delivery of biologic therapeutics by bacterial secretion systems
T2  - Expert Reviews in Molecular Medicine
UR  - http://dx.doi.org/10.1017/erm.2017.7
UR  - http://hdl.handle.net/10044/1/45042
VL  - 19
ER  -

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