Publications
16 results found
Pogorielov M, Kravtsova A, Reilly GC, et al., 2017, Experimental evaluation of new chitin–chitosan graft for duraplasty, Journal of Materials Science: Materials in Medicine, Vol: 28, ISSN: 0957-4530
Tetteh G, 2017, Polyurethane-based Scaffolds for Bone Tissue Engineering. The Role of Hydroxyapatite Particles, Solvent Combinations, Electrospun Fibre Orientations, In Vivo & In Vitro Characterisation, and Particulate Leached Foams for creating 3-D Bone Models.
While small bone defects heal spontaneously, critical size defects may exceed the body’s regenerative capabilities, and require the use of bone substitutes and implants. To date, in vitro and in vivo testing of implants remains the gold standard for rigorous mechanical stability and biological safety checks. Current 2D in vitro testing is limited by a lack of dynamic environment and an inability to investigate mechanical strength of the attachment between the bone-matrix and implant surface. 3D in vivo tests are also limited by differences in the behaviour and structure of human and animal cells, high costs and difficulty of replicating human ageing effects. The aim of this thesis is to develop biocompatible and osteoconductive polyurethane-based scaffolds with optimal mechanical and biological properties that can be used as 3D in vitro bone models for bone regeneration and implant testing. 17 Plain-PU and PU-HA scaffolds were fabricated from three different medical grade polyether-urethanes, namely, Z1A1, Z3A1 and Z9A1. The polymer’s ability to dissolve in graded concentrations of DMF/THF solvents was assessed as part of this study. Composite scaffolds containing nano or micro HA particles were fabricated in a ratio of 3 PU: 1 HA by doping PU solutions with HA particles. Electrospinning, freeze drying, freeze extraction and particulate leaching were the main fabrication techniques explored for creating scaffolds. Electrospun scaffolds with non-aligned fibres were spun at 300 rpm whilst those with aligned fibres were spun at 1300 rpm. Particulate leaching using NaCl particles optimized 3 novel fabrication protocols namely, the layer-by-layer, homogenized or physical-mixing techniques for creating highly porous PU-based constructs. Investigation of non-aligned electrospun scaffolds showed that the choice of solvents, on their own or in combination, strongly influences the final properties of solution, hence the fibre morphology of scaffolds. Reducing the
Tetteh G, Reilly GC, Delaine-Smith R, et al., 2016, Collagen and Mineral Deposition by MLO-A5 Late-Stage Osteoblasts, is Guided by the Fibre Alignment of Electrospun Scaolds, 22nd Congress of the European Society of Biomechanics
Tetteh G, Rehman IU, Reilly GC, et al., 2016, A 3-dimensional biomimetic in vitro bone model for testing small orthopaedic implants, 10th World Biomaterials Congress
Tetteh G, Rehman IU, Reilly GC, 2015, “in vivo and in vitro Characterization of Porous Polyurethane-Hydroxyapatite Scaolds as A Bone Substitute, 27th European Conference on Biomaterials
Tetteh G, Puwanun S, Rehman IU, et al., 2015, A Tissue Engineered Bone Membrane for Cleft Palate Repair, 21st Congress of the European Society of Biomechanics
Tetteh G, Pogorielov M, Rehman IU, et al., 2015, Developing Mechanically-Optimized & Highly Porous Polyurethane-Hydroxyapatite Constructs for Bone Tissue Engineering, 14th Annual Conference of the UK Society for Biomaterials
Tetteh G, Rehman IU, Reilly GC, 2015, Using Tissue Engineering to develop an in vitro 3D Bone Model, Orthopedic Research Society Conference
Tetteh G, Khan AS, Delaine-Smith RM, et al., 2014, Electrospun polyurethane/hydroxyapatite bioactive Scaffolds for bone tissue engineering: The role of solvent and hydroxyapatite particles, Journal of the Mechanical Behavior of Biomedical Materials, Vol: 39, Pages: 95-110, ISSN: 1751-6161
Tetteh G, Rehman IU, Reilly GC, 2014, Engineering an in vitro 3D Bone Model for Implant Testing, MECBioeng14 Conference
Tetteh G, Rehman IU, Reilly GC, 2014, Particulate Leached Scaolds for an in vitro 3D Bone Model for Implant Testing, 7th World Congress of Biomechanics
Tetteh G, Rehman IU, Reilly GC, 2014, Bioactive Scaolds as Bone Templates for in vitro Testing, Tissue & Cell Engineering Society, ISSN: 2522-235X
Tetteh G, Rehman IU, Reilly GC, 2013, A polyurethane-hydroxyapatite composite scaffold as a template for an in vitro bone model, 5th International Conference on Mechanics of Biomaterials and Tissues
Tetteh G, Rehman IU, Reilly GC, 2013, Polyurethane-Hydroxyapatite composite scaffolds for in vitro bone tissue engineering, Tissue and Cell Engineering Society (TCES), ISSN: 2522-235X
Tetteh G, Effah Kaufmann E, 2011, Design of an Efficient Steriliser, 4th Ghana Biomedical Convention
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.