Publications
348 results found
Donaldson GC, Seemungal TA, Patel IS, et al., 2005, Airway and systemic inflammation and decline in lung function in patients with COPD, Chest, Vol: 128, Pages: 1995-2004, ISSN: 0012-3692
STUDY OBJECTIVES: Patients with COPD experience lower airway and systemic inflammation, and an accelerated decline in FEV1. There is no evidence on whether this inflammation changes over time, or if it is associated with a faster decline in FEV1. PATIENTS AND DESIGN: A cohort of 148 COPD patients (100 men) was monitored daily for a median of 2.91 years (interquartile range [IQR], 2.1 to 4.8). At recruitment, median age was 68.5 years (IQR, 62.5 to 73.6) and FEV1 as percentage of predicted (FEV1%Pred) was 38.5% (IQR, 27.7 to 50.3). RESULTS: During the study, the patients experienced 1,389 exacerbations, a median of 2.52/yr (IQR, 1.48 to 3.96) and FEV1 declined by 40.2 mL/yr or as FEV1%Pred by 1.5%/yr. Concerning inflammatory markers, sputum interleukin (IL)-6 rose by 9 pg/mL/yr, sputum neutrophil count rose by 1.64 x 10(6) cells per gram sputum per year, an plasma fibrinogen rose by 0.10 g/L/yr (all p < 0.05). Patients with frequent exacerbations (> or = 2.52/yr) had a faster rise over time in plasma fibrinogen and sputum IL-6 of 0.063 g/L/yr (p = 0.046, n = 130) and 29.5 pg/mL/yr (p < 0.001, n = 98), respectively, compared to patients with infrequent exacerbations (< 2.52/yr). Using the earliest stable (nonexacerbation) measured marker, patients whose IL-6 exceeded the group median had a faster FEV1%Pred decline of 0.42%/yr (p = 0.018). Similarly, a high neutrophil count or fibrinogen were associated with a faster FEV1%Pred decline of 0.97%/yr (p = 0.001) and 0.40%/yr (p = 0.014), respectively. CONCLUSIONS: In COPD, airway and systemic inflammatory markers increase over time; high levels of these markers are associated with a faster decline in lung function.
Donaldson G, Wilkinson TM, Hurst JR, et al., 2005, Exacerbations and time spent outdoors in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 171, Pages: 446-452, ISSN: 1073-449X
Farre R, Lloyd-Owen SJ, Ambrosino N, et al., 2005, Quality control of equipment in home mechanical ventilation: a European survey, European Respiratory Journal, Vol: 26, Pages: 86-94, ISSN: 0903-1936
Lloyd-Owen SJ, Donaldson GC, Ambrosino N, et al., 2005, Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey, Eur Respir J, Vol: 25, Pages: 1025-1031, ISSN: 0903-1936
The study was designed to assess the patterns of use of home mechanical ventilation (HMV) for patients with chronic respiratory failure across Europe. A detailed questionnaire of centre details, HMV user characteristics and equipment choices was sent to carefully identified HMV centres in 16 European countries. A total of 483 centres treating 27,118 HMV users were identified. Of these, 329 centres completed surveys between July 2001 and June 2002, representing up to 21,526 HMV users and a response rate of between 62% and 79%. The estimated prevalence of HMV in Europe was 6.6 per 100,000 people. The variation in prevalence between countries was only partially related to the median year of starting HMV services. In addition, there were marked differences between countries in the relative proportions of lung and neuromuscular patients using HMV, and the use of tracheostomies in lung and neuromuscular HMV users. Lung users were linked to a HMV duration of <1 yr, thoracic cage users with 6-10 yrs of ventilation and neuromuscular users with a duration of > or =6 yrs. In conclusion, wide variations exist in the patterns of home mechanical ventilation provision throughout Europe. Further work is needed to monitor its use and ensure equality of provision and access.
Perera WR, Hammond LJ, Hurst JR, et al., 2004, Peripheral blood neutrophils in stable COPD and at exacerbation, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: 58-58, ISSN: 0040-6376
Wilkinson TMA, Hurst JR, Perera WR, et al., 2004, Relationship between disease severity and airway inflammatory response at exacerbations of COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 59-59, ISSN: 0040-6376
Wilkinson TMA, Hurst JR, Perera WR, et al., 2004, Consequences of respiratory syncytial virus infection in patients with stable COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 2-2, ISSN: 0040-6376
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Powrie DJ, Wilkinson TM, Donaldson GC, et al., 2004, Chronic sputum production is associated with increased lower airway bacterial colonisation in COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 58-58, ISSN: 0040-6376
Perera WR, Hammond LJ, Hurst JR, et al., 2004, Peripheral blood T cell subsets in stable COPD and at exacerbation, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: 58-59, ISSN: 0040-6376
Keatinge WR, Donaldson GC, Woodall AA, et al., 2004, Winter mortality in elderly people in Britain [1] (multiple letters), British Medical Journal, Vol: 329, Pages: 976-977, ISSN: 0959-8146
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- Citations: 2
Borg S, Ericsson A, Wedzicha J, et al., 2004, A computer simulation model of the natural history and economic impact of chronic obstructive pulmonary disease, Value in Health, Vol: 7, Pages: 153-167, ISSN: 1098-3015
Wilkinson TM, Donaldson GC, Hurst JR, et al., 2004, Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 169, Pages: 1298-1303, ISSN: 1073-449X
Hurst JR, Wilkinson TM, Donaldson GC, et al., 2004, Upper airway symptoms and quality of life in chronic obstructive pulmonary disease (COPD), Respiratory Medicine, Vol: 98, Pages: 767-770
Keatinge WR, Donaldson GC, 2004, The impact of global warming on health and mortality, Southern Medical Journal, Vol: 97, Pages: 1093-1099
Keatinge WR, Donaldson GC, 2004, Winter mortality in elderly people in Britain: action on outdoor cold stress is needed to reduce winter mortality, BMJ (Clinical Research Ed.), Vol: 329, ISSN: 0959-8138
Patel IS, Vlahos I, Wilkinson TM, et al., 2004, Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 170, Pages: 400-407, ISSN: 1073-449X
Hurst J, Perera W, Wilkinson TMA, et al., 2003, Nasal inflammatory markers in adults with and without COPD, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 85-85, ISSN: 0040-6376
Hurst J, Wilkinson TMA, Perera W, et al., 2003, A comparative study of upper and lower airway inflammatory markers in stable COPD, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 87-87, ISSN: 0040-6376
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- Citations: 1
Donaldson GC, Seemungal TAR, Patel IS, et al., 2003, Longitudinal changes in the nature, severity and frequency of COPD exacerbations, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 931-936, ISSN: 0903-1936
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- Citations: 139
Wilkinson TMA, Donaldson GC, Hurst JR, et al., 2003, Benefits of early treatment on outcome of COPD exacerbations, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 74-74, ISSN: 0040-6376
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- Citations: 1
Hurst JR, Donaldson GC, Wedzicha JA, 2003, Prednisone for chronic obstructive pulmonary disease, New England Journal of Medicine, Vol: 349, Pages: 1288-1290, ISSN: 0028-4793
Donaldson GC, Seemungal TA, Patel IS, et al., 2003, Longitudinal changes in the nature, severity and frequency of COPD exacerbations, European Respiratory Journal, Vol: 22, Pages: 931-936, ISSN: 0903-1936
Donaldson GC, Keatinge WR, Saunders RD, 2003, Cardiovascular responses to heat stress and their adverse consequences in healthy and vulnerable human populations, International Journal of Hyperthermia, Vol: 19, Pages: 225-235, ISSN: 0265-6736
Wedzicha JA, Donaldson GC, 2003, Exacerbations of chronic obstructive pulmonary disease, Respiratory Care, Vol: 48, Pages: 1204-1213
Wilkinson TM, Patel IS, Wilks M, et al., 2003, Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 167, Pages: 1090-1095, ISSN: 1073-449X
Donaldson GC, Keatinge WR, Nayha S, 2003, Changes in summer temperature and heat-related mortality since 1971 in North Carolina, South Finland, and Southeast England, Environmental Research, Vol: 91, Pages: 1-7, ISSN: 0960-9822
Donaldson GC, Keatinge WR, 2003, Cold related mortality in England and Wales; influence of social class in working and retired age groups, Epidemiology and Community Health, Vol: 57, Pages: 790-791, ISSN: 0143-005X
Roberts NJ, Lloyd-Owen SJ, Rapado F, et al., 2003, Relationship between chronic nasal and respiratory symptoms in patients with COPD, Respir Res, Vol: 97, Pages: 909-914, ISSN: 1465-9921
Fleming DM, Cross KW, Watson JM, et al., 2002, Method of calculating mortality attributed to influenza is disputed [5] (multiple letters), British Medical Journal, Vol: 324, Pages: 1337-1338, ISSN: 0959-8146
Donaldson GC, Keatinge WR, 2002, Excess winter mortality: influenza or cold stress? Observational study, BMJ, Vol: 324, Pages: 89-90, ISSN: 0959-8138
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