Publications
348 results found
Mackay AJ, Donaldson GC, Patel ARC, et al., 2011, CHANGES IN AIRWAY AND SYSTEMIC IL-18 LEVELS AT EXACERBATION IN COPD PATIENTS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A115-A116, ISSN: 0040-6376
Thurston SJ, Donaldson GC, McHugh TD, et al., 2011, IMPACT OF COPD SEVERITY AND SPUTUM PRODUCTION ON ANTIBIOTIC RESISTANCE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A11-A11, ISSN: 0040-6376
Patel ARC, Donaldson GC, Mackay AJ, et al., 2011, GENDER DIFFERENCES IN THE PREVALENCE OF COMORBIDITIES IN COPD PATIENTS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A86-A87, ISSN: 0040-6376
Patel ARC, Donaldson GC, Mackay AJ, et al., 2011, THE PREVALENCE OF β-BLOCKER PRESCRIPTION IN COPD PATIENTS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A175-A175, ISSN: 0040-6376
Garcha DS, Thurston SJ, Patel ARC, et al., 2011, A COMPARISON OF PREVALENCE AND LOAD OF AIRWAY BACTERIA IN COPD PATIENTS WITH PAIRED STABLE AND EXACERBATION STATE SAMPLES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A11-A11, ISSN: 0040-6376
Patel ARC, Donaldson GC, Mackay AJ, et al., 2011, Health Status In Patients With Chronic Obstructive Pulmonary Disease And Comorbid Ischaemic Heart Disease, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Garcha DS, Thurston SJ, Patel ARC, et al., 2011, Quantitative PCR-Based Detection Of Typical And Atypical Bacterial Strains In COPD Patients And Relationship To Culture, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Quint JK, Donaldson GC, Kumari M, et al., 2011, SERPINA1 11478G→A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPD, Thorax, Vol: 66, Pages: 418-424, ISSN: 1468-3296
The α(1)-antitrypsin 11478G→A polymorphism may be associated with attenuated acute α(1)-antitrypsin responses. It was hypothesised that patients with chronic obstructive pulmonary disease (COPD) and this mutation have accelerated lung function decline.
Primhak RA, Hicks B, Shaw NJ, et al., 2011, Use of home oxygen for children in England and Wales, Archives of Disease in Childhood, Vol: 96, Pages: 389-U151, ISSN: 0003-9888
Quint JK, Donaldson GC, Hurst JR, et al., 2011, Predictive accuracy of patient-reported exacerbation frequency in COPD, Eur Respir J, Vol: 37, Pages: 501-507, ISSN: 1399-3003
Chronic obstructive pulmonary disease (COPD) exacerbation frequency is important for clinical risk assessment and trial recruitment. In order to accurately establish exacerbation frequency, patients need to be followed for 1 yr, although this is not always practical. 1) Patient recall of exacerbation number during the year prior to recruitment to the London COPD cohort was compared with the number of exacerbations recorded on diary cards during the subsequent year; and 2) patient recall of their exacerbation number after 1 yr of follow-up was compared with documented exacerbations over the same year. A total of 267 patients (forced expiratory volume in 1 s 1.14 L) recorded worsening of respiratory symptoms on daily diary cards for 1 yr. Exacerbations were defined according to previously validated criteria. There was no difference between the exacerbation number recalled by patients prior to recruitment and the number detected during the first year (median 2.0 (interquartile range 1.0-4.0) and 2.0 (1.0-4.0); expected agreement 76.4%; agreement 84.6%; kappa = 0.3469). There was no difference between the number of exacerbations remembered by patients and the number recorded on diary cards over the same 1-yr period (2.0 (1.0-4.0) for both groups; expected agreement 74.9%; actual agreement 93.3%; kappa = 0.6146). Patients remember the number of exacerbations they have in a year. Accuracy is increased when comparing the same 1-yr period. Patient recall is sufficiently robust for stratification into frequent and infrequent exacerbator groups for subsequent years.
Aaron SD, Donaldson GC, Whitmore GA, et al., 2011, Time Course And Phenotype Of COPD Exacerbations, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Al Ahmari AD, Donaldson GC, Wedzicha JA, 2011, Relationship Between Annual Changes In 6 Minute Walking Distance And Daily Time Outdoors Measurements In COPD Patients, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Quint JK, Donaldson GC, Goldring JJ, et al., 2011, Effect Of Time Outdoors And Hours Of Daylight On Vitamin D Levels In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Mackay AJ, Patel A, Donaldson GC, et al., 2011, Utility Of The COPD Assessment TestTM (CAT) In Stable COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Mackay AJ, Patel A, Donaldson GC, et al., 2011, The COPD Assessment TestTM (CAT) Can Detect Changes In Health Status During COPD Exacerbations, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Mackay AJ, Donaldson GC, Patel ARC, et al., 2010, C-REACTIVE PROTEIN AT ONSET PREDICTS SYMPTOM RESOLUTION IN ACUTE EXACERBATIONS OF COPD, Publisher: B M J PUBLISHING GROUP, Pages: A126-A126, ISSN: 0040-6376
Garcha DS, Thurston SJ, Patel ARC, et al., 2010, QUANTITATIVE PCR-BASED DETECTION AND QUANTIFICATION OF ATYPICAL BACTERIA AT BASELINE AND EXACERBATION OF COPD, Publisher: B M J PUBLISHING GROUP, Pages: A124-A124, ISSN: 0040-6376
George CG, Quint JK, Sapsford RJ, et al., 2010, SERUM PARC (CCL18) AND EXACERBATION FREQUENCY IN COPD, Publisher: B M J PUBLISHING GROUP, Pages: A126-A127, ISSN: 0040-6376
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Hurst JR, Donaldson GC, Quint JK, et al., 2010, Domiciliary pulse-oximetry at exacerbation of chronic obstructive pulmonary disease: prospective pilot study, BMC Pulmonary Medicine, Vol: 10, ISSN: 1471-2466
Hurst J, Donaldson G, Wedzicha J, 2010, From the authors, American Journal of Respiratory and Critical Care Medicine, Vol: 182, ISSN: 1073-449X
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Patel ARC, Karmali S, Donaldson GC, et al., 2010, Prevalence Of Herpes Zoster In COPD And Relationships With Inhaled Corticosteroids, Exacerbation Frequency And FEV<sub>1</sub>., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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Donaldson GC, Hurst JR, Smith CJ, et al., 2010, Increased risk of myocardial infarction and stroke following exacerbation of COPD, Chest, Vol: 137, Pages: 1091-1097, ISSN: 1931-3543
Patients with COPD are at risk for cardiovascular events. This is attributed to increased systemic inflammation. The course of COPD is punctuated by exacerbations, which further increase systemic inflammation, but the risk of vascular events in the postexacerbation period has never been defined.
Donaldson G, Christidis N, Stott PA, 2010, Causes for the recent changes in cold- and heat-related mortality in England and Wales, Climatic Change: an interdisciplinary, international journal devoted to the description, causes and implications of climatic change, Vol: 102, Pages: 539-553
Donaldson GC, Goldring JJP, Patel A, et al., 2010, Effect Of Exacerbations Frequency On Body Mass Index And Appetite In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Donaldson GC, Goldring JJP, Patel A, et al., 2010, Poor Health Status Independently Associated With Longer Exacerbation Recovery In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Thurston SJ, Ling C, Ciesielczuk H, et al., 2010, Development of a multiplex qPCR for bacterial analysis with sputum from patients with COPD., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Jones RC, Harding S, Hyland ME, et al., 2010, BODE plus DOSE plus Pa-O2 equals DO RE MI BOX? reply, American Journal of Respiratory and Critical Care Medicine, Vol: 182, Pages: 1089-1089, ISSN: 1073-449X
Quint JK, Donaldson GC, Goldring JJ, et al., 2010, Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD, Chest, Vol: 137, Pages: 812-822, ISSN: 1931-3543
Human rhinovirus (HRV) is the most frequent virus associated with COPD exacerbations. Viral infections increase exacerbation severity and likelihood of hospitalization. As ease of sampling blood makes serum a more practical marker than sputum, we investigated whether changes in serum interferon-gamma-inducible protein 10 (IP-10) from baseline to exacerbation were higher in airway HRV-positive exacerbations and whether IP-10 levels related to HRV load.
Patel ARC, Karmali S, Goldring JJP, et al., 2009, EXTRAPULMONARY POLYPHARMACY AND CARDIOVASCULAR MEDICATIONS IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A41-A41, ISSN: 0040-6376
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Goldring JJP, Donaldson GC, Quint JK, et al., 2009, INFLAMMATORY PROFILE OF COPD EXACERBATIONS ASSOCIATED WITH DUAL BACTERIAL ISOLATES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A119-A120, ISSN: 0040-6376
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