Publications
348 results found
Goldring JJP, Donaldson GC, Quint JK, et al., 2009, POLYMICROBIAL AIRWAY COLONISATION AND SYSTEMIC INFLAMMATION IN STABLE COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A132-A132, ISSN: 0040-6376
Rudd PJ, Donaldson GC, Quint JK, et al., 2009, GEOGRAPHICAL INFLUENCE ON REPORTING COPD EXACERBATIONS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A115-A115, ISSN: 0040-6376
Donaldson GC, Quint JK, Powrie D, et al., 2009, CHANGES IN PLASMA COTININE AT EXACERBATION AND FASTER EXACERBATION RECOVERY IN NON-SMOKERS IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A116-A116, ISSN: 0040-6376
Quint JK, Donaldson GC, Goldring JJP, et al., 2009, VITAMIN D LEVELS AND SUSCEPTIBILITY TO HUMAN RHINOVIRUS EXACERBATIONS OF COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A117-A117, ISSN: 0040-6376
Patel ARC, Karmali S, Goldring JJP, et al., 2009, RELATIONSHIPS BETWEEN CO-MORBIDITIES, EXACERBATION FREQUENCY AND FEV<sub>1</sub> IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A134-A135, ISSN: 0040-6376
Hurst J, Donaldson G, Wedzicha J, 2009, From the authors, American Journal of Respiratory and Critical Care Medicine, Vol: 180, ISSN: 1073-449X
Baghai-Ravary R, Quint JK, Goldring JJP, et al., 2009, Determinants and impact of fatigue in patients with chronic obstructive pulmonary disease, RESPIRATORY MEDICINE, Vol: 103, Pages: 216-223, ISSN: 0954-6111
- Author Web Link
- Cite
- Citations: 85
Quint J, Alber D, Goldring J, et al., 2009, IP10: A Biomarker for Cold Associated COPD Exacerbations., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Quint J, Alber D, Goldring J, et al., 2009, IP10: A Biomarker for Cold Associated COPD Exacerbations., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Quint J, Alber D, Goldring J, et al., 2009, IP10 and HRV Load in Stable COPD and Controls, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Hurst J, Donaldson G, Wedzicha W, 2009, Frequent Exacerbators in COPD: Who Are They?, AM J RESP CRIT CARE, Vol: 180, Pages: 284-284, ISSN: 1073-449X
Quint J, Donaldson G, Hurst J, et al., 2009, Patient Recalled Exacerbation Frequency and Quality of Life in COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Jones RC, Donaldson GC, Chavannes NH, et al., 2009, Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease-the dose index, American Journal of Respiratory and Critical Care Medicine, Pages: 200902-200902
Jones RC, Donaldson GC, Chavannes NH, et al., 2009, Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: the DOSE Index, Am J Respir Crit Care Med, Vol: 180, Pages: 1189-1195, ISSN: 1535-4970
Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life. Single measures such as lung function provide a limited reflection of how the disease affects patients. Composite measures have the potential to account for many of the facets of COPD.
Hurst JR, Donaldson GC, Quint JK, et al., 2009, Temporal Clustering of Exacerbations in Chronic Obstructive Pulmonary Disease, AM J RESP CRIT CARE, Vol: 179, Pages: 369-374, ISSN: 1073-449X
Rationale: Exacerbations are important events in chronic obstructive pulmonary disease. Preventing exacerbations is a key treatment goal. Observational data suggest that after a first exacerbation, patients may be at increased risk of a second exacerbation, but this has not been specifically studied. We hypothesized that exacerbations may cluster together in time, a finding that would have important implications for targeting preventative interventions and the analysis of clinical trial data.Objectives: To assess whether exacerbations are random events, or cluster in time.Methods: A total of 297 patients in the London chronic obstructive pulmonary disease cohort recorded daily symptoms and were assessed for a total of 904 patient-years. The observed timing of second exacerbations after an initial exacerbation was compared with that expected should exacerbations occur randomly.Measurements and Main Results: The observed timing distribution of second exacerbations differed significantly (P < 0.001) from the expected exponential function (shape parameter of the fitted Weibull function, 0.966 [95% confidence interval, 0.948-0.985]), suggesting that more second exacerbations occurred sooner than later and that exacerbations cluster together in time. Twenty-seven percent of first exacerbations were followed by a second recurrent event within 8 weeks. Approximately one third of exacerbations were recurrent exacerbations. Although initial exacerbations were milder than isolated events, they were not less likely to receive treatment, and under-treatment of initial events is not a plausible explanation for exacerbation recurrence. Recurrent exacerbations contribute significantly to overall exacerbation frequency (rho 0.81; P < 0.0001).Conclusions: Exacerbations are not random events but cluster together in time such that there is a high-risk period for recurrent exacerbation in the 8-week period after an initial excerbation.
Donaldson G, Seemungal TAR, Patel IS, et al., 2009, Airway and systemic inflammation and decline in lung function in patients with COPD. 2005, Chest
Quint JK, Goldring JJP, Hurst JR, et al., 2008, CYTOKINE DIFFERENCES BETWEEN RHINOVIRAL AND BACTERIAL EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A67-A67, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 2
Goldring JJP, Quint JK, Baghai-Ravary R, et al., 2008, EXACERBATION INTERVALS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS ARE NOT INFLUENCED BY THE SPECIES OF THE PRINCIPAL COLONISING LOWER AIRWAY BACTERIA, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A129-A129, ISSN: 0040-6376
Quint JK, Goldring JJP, Hurst JR, et al., 2008, COMPARISON OF PATIENT RECALLED EXACERBATION FREQUENCY AND EXACERBATION FREQUENCY IN THE NEXT YEAR, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A130-A130, ISSN: 0040-6376
Donaldson GC, Esmond G, Balfour-Lynn I, et al., 2008, DEPRIVATION, RURALITY AND THE USE OF HOME OXYGEN IN ENGLAND AND WALES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A75-A75, ISSN: 0040-6376
, 2008, Correction, Thorax, Vol: 63, Pages: 753-753, ISSN: 0040-6376
Donaldson GC, Seemungal TAR, Bhowmik A, et al., 2008, Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease (vol 57, pg 847, 2002), THORAX, Vol: 63, Pages: 753-753, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 14
Powrie DJ, Wilkinson TMA, Donaldson GC, et al., 2008, Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD, REVISTA PORTUGUESA DE PNEUMOLOGIA, Vol: 14, Pages: 573-576, ISSN: 0873-2159
- Author Web Link
- Cite
- Citations: 3
Goldring JJP, Donaldson GC, 2008, Effect of exacerbations on disease progression and mortality, Chronic Obstructive Pulmonary Disease Exacerbations, Pages: 217-224, ISBN: 9781420070866
The rate of forced expiratory volume in one second (FEV1) decline is a physiological measure of disease progression and is widely used as an outcome measure for clinical trials of chronic obstructive pulmonary disease (COPD) treatment because it is predictive of morbidity, mortality, quality of life, and hospitalization rates (1). Estimates of the decline in FEV1 in nonsmoking men and women vary between 29.6 and 19.6 mL/yr (2,3). The rate of decline classically accelerates with age, but might appear to slow at the very upper end of the age range, as only those people with the slower rates of decline survive.
Quint JK, Baghai-Ravary R, Donaldson GC, et al., 2008, Relationship between depression and exacerbations in COPD, Eur Respir J, Vol: 32, Pages: 53-60, ISSN: 0903-1936
Chronic obstructive pulmonary disease is associated with exacerbations. Some patients are prone to frequent exacerbations and these individuals have a worse quality of life, greater limitation of their daily activity and faster disease progression than patients with less frequent exacerbations.A prospective study in a well-characterised cohort was performed and it was assessed whether depression, as determined by the Centre for Epidemiologic Studies Depression Scale, was related to exacerbation frequency, systemic inflammation and various social factors. The associations of any increase in depressive symptoms at exacerbation were also investigated.Frequent exacerbators had a significantly higher median (interquartile range) baseline depression score than infrequent exacerbators (17.0 (7.0-25.0) and 12.0 (6.0-18.0), respectively). Depressed patients spend significantly less time outdoors and had significantly worse quality of life as measured by the St George's Respiratory Questionnaire. Depression increased significantly in patients from baseline to exacerbation (12.5 (5.0-19.0) and 19.5 (12.0-28.0) respectively).The present study is the first to show a relationship between depression and exacerbation frequency in patients with chronic obstructive pulmonary disease. The finding that frequent exacerbators are more depressed than infrequent exacerbators is relevant, as exacerbation frequency is an important outcome measure in chronic obstructive pulmonary disease.
Baghai-Ravary R, Quint JK, Goldring JJP, et al., 2007, Determinants of fatigue in stable chronic obstructive pulmonary disease, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A147-A148, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 1
Quint JK, Baghai-Ravary R, Goldring JJP, et al., 2007, Do frequent exacerbators with COPD perceive their exacerbation frequency more accurately than infrequent exacerbators?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A119-A119, ISSN: 0040-6376
Baghai-Ravary R, Quint JK, Goldring JJP, et al., 2007, Acute exacerbations of chronic obstructive pulmonary disease, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A117-A117, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 1
Quint JK, Baghai-Ravary R, Goldring JJP, et al., 2007, Is exacerbation frequency related to social factors?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A118-A118, ISSN: 0040-6376
Donaldson GC, Edmonds G, Balfour-Lynn I, et al., 2007, Development of the British thoracic society home oxygen database and prevalence of home oxygen use in England and wales, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A64-A64, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 3
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.