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@article{Paschalaki:2022,
author = {Paschalaki, K and Rossios, C and Pericleous, C and MacLeod, M and Rothery, S and Donaldson, G and Wedzicha, J and Gorgoulis, V and Randi, A and Barnes, P},
journal = {Thorax},
title = {Inhaled corticosteroids reduce senescence in endothelial progenitor cells from COPD patients},
url = {https://thorax.bmj.com/content/77/6/616.info},
volume = {77},
year = {2022}
}

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TY  - JOUR
AB  - Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonarydisease (COPD) and cardiovascular disease. Using endothelial-colony-forming-cells (ECFC),we have demonstrated accelerated senescence in smokers and COPD patients compared tonon-smokers. Subgroup analysis suggests that ECFC from COPD patients on inhaledcorticosteroids (ICS) (n=14; 8 on ICS) exhibited significantly reduced senescence(Senescence-associated-beta galactosidase activity, p21CIP1), markers of DNA damageresponse (DDR) and IFN-γ-inducible-protein-10 compared to COPD patients not on ICS. Invitro studies using human-umbilical-vein-endothelial-cells showed a protective effect of ICSon the DDR, senescence and apoptosis caused by oxidative-stress, suggesting a protectivemolecular mechanism of action of corticosteroids on endothelium.
AU  - Paschalaki,K
AU  - Rossios,C
AU  - Pericleous,C
AU  - MacLeod,M
AU  - Rothery,S
AU  - Donaldson,G
AU  - Wedzicha,J
AU  - Gorgoulis,V
AU  - Randi,A
AU  - Barnes,P
PY  - 2022///
SN  - 0040-6376
TI  - Inhaled corticosteroids reduce senescence in endothelial progenitor cells from COPD patients
T2  - Thorax
UR  - https://thorax.bmj.com/content/77/6/616.info
UR  - http://hdl.handle.net/10044/1/93096
VL  - 77
ER  -

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Emeritus ProfessorGavinDonaldson

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