Summary
Ghita's research programme is interdisciplinary at the interface between cell biology, immunology and artificial intelligence, aimed to:
- Decipher the molecular and cellular mechanisms that bridge between the adaptive and innate immunity during tumour inflammation and autoimmunity.
- Tailor drug design to improve the outcome of defective immune responses.
Selected publications
Ogunleye AZ, Piyawajanusorn C, Gonçalves A, Ghislat G, Ballester PJ. (2022) Interpretable machine learning models to predict the resistance of breast cancer patients to doxorubicin from their microRNA Profiles. Advanced Science. DOI
Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, et al. (2021) NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity. Science Immunology. DOI
Ghislat G, Rahman T, Ballester PJ. (2020) Identification and validation of Carbonic Anhydrase II as the first target of the anti-inflammatory drug Actarit. Biomolecules. DOI
Cellular & Molecular Immunology. DOI
Moreau K*, Ghislat G*, Hochfeld W, Renna M, Zavodszky E, Runwal G, et al. (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. Nature Communications. DOI
Lin F*, Ghislat G*, Luo S, Renna M, Siddiqi F, Rubinsztein DC. (2015) XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation. Human Molecular Genetics. DOI
Ghislat G, Patron M, Rizzuto R, Knecht E. (2012) Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2 /Calmodulin-dependent Kinase Kinase-beta (CaMKK-beta). Journal of Biological Chemistry. DOI
Ghislat G, Aguado C, Knecht E (2012) Annexin A5 stimulates autophagy and inhibits endocytosis. Journal of Cell Science. DOI