Publications
227 results found
Foo JYA, Parsley CL, Wilson SJ, et al., 2005, Detection of central respiratory events using pulse transit time in infants, 2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, Pages: 2579-2582, ISSN: 1094-687X
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- Citations: 6
Maxwell PH, Williams GR, 2005, Research training in the 21st century: a role for part time MSc courses, BMJ: British Medical Journal, Vol: 330
Foo JYA, Wilson SJ, Williams GR, et al., 2005, Use of regression equation of peripheral pulse timing characteristics to predict hypertension in children, 2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, Pages: 4123-4126, ISSN: 1094-687X
Barakat MT, Ashrafian H, Todd JF, et al., 2004, Severe hypercalcaemia parathyroid from secretion of hormone-related peptide, LANCET ONCOLOGY, Vol: 5, Pages: 633-635, ISSN: 1470-2045
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- Citations: 8
Murphy E, Williams GR, 2004, The thyroid and the skeleton, CLINICAL ENDOCRINOLOGY, Vol: 61, Pages: 285-298, ISSN: 0300-0664
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- Citations: 109
Frankton S, Harvey CB, Gleason LM, et al., 2004, Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor β1, MOLECULAR ENDOCRINOLOGY, Vol: 18, Pages: 1631-1642, ISSN: 0888-8809
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- Citations: 22
Barakat MT, Ashrafian H, Todd JF, et al., 2004, Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 19, Pages: 977-980, ISSN: 0931-0509
Williams GR, 2004, Thyroid hormones, mast cells and bone, Sociedad Iberoamericano de Informacion Cientifica, Vol: www.siicsalud.com/des/des035/04115098.htm
Siebler T, Robson H, Shalet SM, et al., 2004, Thyroid hormone and the growth plate, HORMONE RESEARCH, Vol: 62, Pages: 116-116, ISSN: 0301-0163
Harvey CB, Stevens DA, Williams AJ, et al., 2003, Analysis of thyroid hormone responsive gene expression in osteoblastic cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 213, Pages: 87-97, ISSN: 0303-7207
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- Citations: 7
Bassett JHD, Harvey CB, Williams GR, 2003, Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 213, Pages: 1-11, ISSN: 0303-7207
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- Citations: 275
Bassett JHD, Williams GR, 2003, The molecular actions of thyroid hormone in bone, TRENDS IN ENDOCRINOLOGY AND METABOLISM, Vol: 14, Pages: 356-364, ISSN: 1043-2760
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- Citations: 181
Stevens DA, Harvey CB, Scott AJ, et al., 2003, Thyroid hormone activates fibroblast growth factor receptor-1 in bone, MOLECULAR ENDOCRINOLOGY, Vol: 17, Pages: 1751-1766, ISSN: 0888-8809
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- Citations: 62
Williams GR, 2003, Thyroid hormone actions in bone and cartilage, Annual Meeting of the Bone-and-Tooth-Society, Publisher: AMER SOC BONE & MINERAL RES, Pages: 1357-1357, ISSN: 0884-0431
O'Shea PJ, Harvey CB, Suzuki H, et al., 2003, A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone, MOLECULAR ENDOCRINOLOGY, Vol: 17, Pages: 1410-1424, ISSN: 0888-8809
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- Citations: 91
Williams GR, 2003, Thyroid hormone action on the skeleton and growth, Encyclopedia of hormones & Related Cell Regulators, Editors: Henry, Norman, Publisher: Academic Pr, Pages: 466-472
O'Shea PJ, Williams GR, 2002, Insight into the physiological actions of thyroid hormone receptors from genetically modified mice, JOURNAL OF ENDOCRINOLOGY, Vol: 175, Pages: 553-570, ISSN: 0022-0795
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- Citations: 157
Siebler T, Robson H, Shalet SM, et al., 2002, Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells, BONE, Vol: 31, Pages: 457-464, ISSN: 8756-3282
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- Citations: 37
Robson H, Siebler T, Shalet SM, et al., 2002, Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth, PEDIATRIC RESEARCH, Vol: 52, ISSN: 0031-3998
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- Citations: 139
Gouveia CH, Schultz JJ, Jackson DJ, et al., 2002, Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis., Thyroid, Vol: 12, Pages: 663-671, ISSN: 1050-7256
Thyroid hormone plays an important role in bone development and metabolism. We used a polymerase chain reaction (PCR)-based mRNA differential display (DD) analysis to obtain a profile of thyroid hormone-responsive genes in osteoblast-like cells (ROS 17/2.8). ROS 17/2.8 cells were treated with 10(-8) M triiodothyronine (T(3)) for 2 and 24 hours. Total RNA was isolated, reverse-transcribed, and amplified using a total of 72 combinations (2 hours) and 240 combinations (24 hours) of 5' and 3' primers. At the 2-hour time point, 1 true-positive novel clone was identified and shown to be the mitochondrial gene, subunit 6 of ATP synthase (ATPase-6). At the 24-hour time point, 3 differentially expressed (DE) mRNAs were confirmed as true-positives including; nonmuscle alkali myosin light chain (NM aMLC), ATPase-6, and one novel clone. T(3)-induction of ATPase-6 mRNA in ROS 17/2.8 cells was seen at 2 and 4 hours, but was maximal at 24 hours (2.1-fold). T(3) induction of ATPase-6 mRNA was increased to fourfold in ROS 17/2.8 cells cultured at a low density. NM aMLC mRNA was modestly upregulated by T(3) in ROS 17/2.8 cells by 1.4-fold, and induction was augmented at low cell density to 1.7-fold. T(3) action on NM aMLC and on the mitochondrial gene ATPase 6, represent novel targets and potential mediators of thyroid hormone action on bone. Cell type, and the extent of cell differentiation, influences T(3) regulation of genes in osteoblast-derived cells.
Harvey CB, Williams GR, 2002, Mechanism of thyroid hormone action, THYROID, Vol: 12, Pages: 441-446, ISSN: 1050-7256
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- Citations: 227
Siddiqi A, Parsons MP, Lewis JL, et al., 2002, TR expression and function in human bone marrow stromal and osteoblast-like cells, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 87, Pages: 906-914, ISSN: 0021-972X
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- Citations: 27
Siebler T, Robson H, Bromley M, et al., 2002, Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow, BONE, Vol: 30, Pages: 259-266, ISSN: 8756-3282
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- Citations: 16
Harvey CB, O'Shea PJ, Scott AJ, et al., 2002, Molecular mechanisms of thyroid hormone effects on bone growth and function, MOLECULAR GENETICS AND METABOLISM, Vol: 75, Pages: 17-30, ISSN: 1096-7192
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- Citations: 90
Williams GR, 2002, Thyroid disease and osteoporosis, Oxford textbook of endocrinology and diabetes, Pages: 677-683, ISBN: 9780192630452
Williams GR, 2001, Thyroid hormone and bone, Harrison's Principles of Internal Medicine, 15th Edition Textbook & Self-Assessment and Board Review, Editors: Braunwald, Fauci, Kasper, Stone, Hauser, Longo, Jameson, Publisher: McGraw-Hill, ISBN: 9780071391023
Williams GR, 2001, RACE-PCR (Rapid amplification of cDNA ends-polymerase chain reaction), Wiley Encyclopedia of Molecular Medicine, Editors: Creighton, Publisher: Wiley-Interscience, Pages: 2713-2717, ISBN: 9780471374947
Gauthier K, Plateroti M, Harvey CB, et al., 2001, Genetic analysis reveals different functions for the products of the thyroid hormone receptor α locus, MOLECULAR AND CELLULAR BIOLOGY, Vol: 21, Pages: 4748-4760, ISSN: 0270-7306
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- Citations: 202
Siebler T, Robson H, Shalet SM, et al., 2001, Glucocorticoids, thyroid hormone and growth hormone interactions: Implications for the growth plate, HORMONE RESEARCH, Vol: 56, Pages: 7-12, ISSN: 0301-0163
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- Citations: 27
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