Imperial College London
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ProfessorGrahamWilliams

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Professor of Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 1383graham.williams

 
 
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Location

 

10N5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Beck-Cormier:2019:10.1002/jbmr.3691,
author = {Beck-Cormier, S and Lelliott, CJ and Logan, JG and Lafont, DT and Leitch, VD and Butterfield, NC and Protheroe, HJ and Croucher, PI and Baldock, PA and Gaultier-Lintia, A and Nicolas, G and Bon, N and Sourice, S and Guicheux, J and Beck, L and Williams, GR and Bassett, JHD},
doi = {10.1002/jbmr.3691},
journal = {Journal of Bone and Mineral Research},
pages = {1101--1114},
title = {Slc20a2, encoding the phosphate transporter PiT2, is a novel genetic determinant of bone quality and strength},
url = {http://dx.doi.org/10.1002/jbmr.3691},
volume = {34},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2–/– mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2–/– mice: yield load (–2.3 SD), maximum load (–1.7 SD), and stiffness (–2.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wildtype controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength.
AU  - Beck-Cormier,S
AU  - Lelliott,CJ
AU  - Logan,JG
AU  - Lafont,DT
AU  - Leitch,VD
AU  - Butterfield,NC
AU  - Protheroe,HJ
AU  - Croucher,PI
AU  - Baldock,PA
AU  - Gaultier-Lintia,A
AU  - Nicolas,G
AU  - Bon,N
AU  - Sourice,S
AU  - Guicheux,J
AU  - Beck,L
AU  - Williams,GR
AU  - Bassett,JHD
DO  - 10.1002/jbmr.3691
EP  - 1114
PY  - 2019///
SN  - 1523-4681
SP  - 1101
TI  - Slc20a2, encoding the phosphate transporter PiT2, is a novel genetic determinant of bone quality and strength
T2  - Journal of Bone and Mineral Research
UR  - http://dx.doi.org/10.1002/jbmr.3691
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450475400186&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68995
VL  - 34
ER  -
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