Imperial College London
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DrGregoryScott

Faculty of Medicine, Department of Brain Sciences

Post-CCT Research Fellow (IPPRF)
 
 
 
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Contact

 

gregory.scott99

 
 
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Location

 

C3NL, Burlington DanesBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mahmud:2022:10.1016/j.jns.2022.120414,
author = {Mahmud, M and Hadi, Z and Prendergast, M and Ciocca, M and Saad, AR and Pondeca, Y and Tai, Y and Scott, G and Seemungal, BM},
doi = {10.1016/j.jns.2022.120414},
journal = {Journal of the Neurological Sciences},
pages = {1--10},
title = {The effect of galvanic vestibular stimulation on postural balance in Parkinson's disease: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1016/j.jns.2022.120414},
volume = {442},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - People with Parkinson's disease (PD) develop postural imbalance and falls. Galvanic Vestibular Stimulation (GVS) may potentially improve postural balance in humans and hence reduce falls in PD. This systematic review and meta-analysis investigate the effects of GVS on postural balance in PD.Six separate databases and research registers were searched for cross-over design trials that evaluated the effects of GVS on postural balance in PD. We used standardized mean difference (Hedges' g) as a measure of effect size in all studies.We screened 223 studies, evaluated 14, of which five qualified for the meta-analysis. Among n=40 patients in five studies (range n=5 to 13), using a fixed effects model we found an effect size estimate of g=0.43 (p<0.001, 95% CI [0.29,0.57]). However, the test for residual heterogeneity was significant (p<0.001), thus we used a random effects model and found a pooled effect size estimate of 0.62 (p>0.05, 95% CI [− 0.17, 1.41], I2=96.21%). Egger's test was not significant and thus trim and funnel plot indicated no bias. To reduce heterogeneity, we performed sensitivity analysis and by removing one outlier study (n=7 patients), we found an effect size estimate of 0.16 (p<0.05, 95% CI [0.01, 0.31], I2=0%).Our meta-analysis found GVS has a favourable effect on postural balance in PD patients, but due to limited literature and inconsistent methodologies, this favourable effect must be interpreted with caution.
AU  - Mahmud,M
AU  - Hadi,Z
AU  - Prendergast,M
AU  - Ciocca,M
AU  - Saad,AR
AU  - Pondeca,Y
AU  - Tai,Y
AU  - Scott,G
AU  - Seemungal,BM
DO  - 10.1016/j.jns.2022.120414
EP  - 10
PY  - 2022///
SN  - 0022-510X
SP  - 1
TI  - The effect of galvanic vestibular stimulation on postural balance in Parkinson's disease: a systematic review and meta-analysis
T2  - Journal of the Neurological Sciences
UR  - http://dx.doi.org/10.1016/j.jns.2022.120414
UR  - https://www.jns-journal.com/article/S0022-510X(22)00276-3/fulltext
UR  - http://hdl.handle.net/10044/1/99605
VL  - 442
ER  -
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