Imperial College London
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DrGregoryScott

Faculty of Medicine, Department of Brain Sciences

Post-CCT Research Fellow (IPPRF)
 
 
 
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Contact

 

gregory.scott99

 
 
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Location

 

C3NL, Burlington DanesBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mallas:2022:10.1523/JNEUROSCI.0564-22.2022,
author = {Mallas, E-J and Gorgoraptis, N and Dautricourt, S and Pertzov, Y and Scott, G and Sharp, D},
doi = {10.1523/JNEUROSCI.0564-22.2022},
journal = {The Journal of Neuroscience},
pages = {9193--9210},
title = {Pathological slow-wave activity and impaired working memory binding in post-traumatic amnesia},
url = {http://dx.doi.org/10.1523/JNEUROSCI.0564-22.2022},
volume = {42},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Associative binding is key to normal memory function and is transiently disrupted during periods of post-traumatic amnesia (PTA) following traumatic brain injury (TBI). Electrophysiological abnormalities including low-frequency activity are common following TBI. Here, we investigate associative memory binding during PTA and test the hypothesis that misbinding is caused by pathological slowing of brain activity disrupting cortical communication. Thirty acute moderate-severe TBI patients (25 males; 5 females) and 26 healthy controls (20 males; 6 females) were tested with a precision working memory paradigm requiring the association of object and location information. Electrophysiological effects of TBI were assessed using resting-state EEG in a subsample of 17 patients and 21 controls. PTA patients showed abnormalities in working memory function and made significantly more misbinding errors than patients who were not in PTA and controls. The distribution of localisation responses was abnormally biased by the locations of non-target items for patients in PTA suggesting a specific impairment of object and location binding. Slow wave activity was increased following TBI. Increases in the delta-alpha ratio indicative of an increase in low-frequency power specifically correlated with binding impairment in working memory. Connectivity changes in TBI did not correlate with binding impairment. Working memory and electrophysiological abnormalities normalised at six-month follow-up. These results show that patients in PTA show high rates of misbinding that are associated with a pathological shift towards lower frequency oscillations.
AU  - Mallas,E-J
AU  - Gorgoraptis,N
AU  - Dautricourt,S
AU  - Pertzov,Y
AU  - Scott,G
AU  - Sharp,D
DO  - 10.1523/JNEUROSCI.0564-22.2022
EP  - 9210
PY  - 2022///
SN  - 0270-6474
SP  - 9193
TI  - Pathological slow-wave activity and impaired working memory binding in post-traumatic amnesia
T2  - The Journal of Neuroscience
UR  - http://dx.doi.org/10.1523/JNEUROSCI.0564-22.2022
UR  - https://www.jneurosci.org/content/42/49/9193
UR  - http://hdl.handle.net/10044/1/100386
VL  - 42
ER  -
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