Imperial College London
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DrGregoryScott

Faculty of Medicine, Department of Brain Sciences

Post-CCT Research Fellow (IPPRF)
 
 
 
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Contact

 

gregory.scott99

 
 
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Location

 

C3NL, Burlington DanesBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{De:2016:brain/aww241,
author = {De, Simoni S and Grover, PJ and Jenkins, PO and Honeyfield, L and Quest, R and Scott, G and Wilson, WH and Majewska, P and Waldman, AD and Patel, MC and Sharp, DJ},
doi = {brain/aww241},
journal = {Brain},
pages = {3137--3150},
title = {Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia},
url = {http://dx.doi.org/10.1093/brain/aww241},
volume = {139},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Post-traumatic amnesia is very common immediately after traumatic brain injury. It is characterised by a confused, agitated state and a pronounced inability to encode new memories and sustain attention. Clinically, post-traumatic amnesia is an important predictor of functional outcome. However, despite its prevalence and functional importance, the pathophysiology of post-traumatic amnesia is not understood. Memory processing relies on limbic structures such as the hippocampus, parahippocampus and parts of the cingulate cortex. These structures are connected within an intrinsic connectivity network, the Default Mode Network. Interactions within the Default Mode Network can be assessed using resting state functional magnetic resonance imaging, which can be acquired in confused patients unable to perform tasks in the scanner. Here we used this approach to test the hypothesis that the mnemonic symptoms of post-traumatic amnesia are caused by functional disconnection within the Default Mode Network. We assessed whether the hippocampus and parahippocampus showed evidence of transient disconnection from cortical brain regions involved in memory processing. 19 traumatic brain injury patients were classified into post-traumatic amnesia and traumatic brain injury control groups, based on their performance on a paired associates learning task.  Cognitive function was also assessed with a detailed neuropsychological test battery. Functional interactions between brain regions were investigated using resting-state functional magnetic resonance imaging. Together with impairments in associative memory patients in post-traumatic amnesia demonstrated impairments in information processing speed and spatial working memory. Patients in post-traumatic amnesia showed abnormal functional connectivity between the parahippocampal gyrus and posterior cingulate cortex. The strength of this functional connection correlated with both associative memory and information processing speed and normal
AU  - De,Simoni S
AU  - Grover,PJ
AU  - Jenkins,PO
AU  - Honeyfield,L
AU  - Quest,R
AU  - Scott,G
AU  - Wilson,WH
AU  - Majewska,P
AU  - Waldman,AD
AU  - Patel,MC
AU  - Sharp,DJ
DO  - brain/aww241
EP  - 3150
PY  - 2016///
SN  - 0006-8950
SP  - 3137
TI  - Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/aww241
UR  - http://hdl.handle.net/10044/1/40572
VL  - 139
ER  -
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