Imperial College London
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Dr Grigoris Grigoriadis

Faculty of Engineering, Department of Bioengineering

 
 
 
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Contact

 

+44 (0)20 7594 2646grigorios.grigoriadis11 Website

 
 
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Location

 

B304BBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Newell:2017:10.1016/j.jmbbm.2016.10.012,
author = {Newell, N and Grigoriadis, G and Christou, A and Carpanen, D and Masouros, S},
doi = {10.1016/j.jmbbm.2016.10.012},
journal = {Journal of The Mechanical Behavior of Biomedical Materials},
pages = {824--830},
title = {Material properties of bovine intervertebral discs across strain rates},
url = {http://dx.doi.org/10.1016/j.jmbbm.2016.10.012},
volume = {65},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The intervertebral disc (IVD) is a complex structure responsible for distributing compressive loading to adjacent vertebrae and allowing the vertebral column to bend and twist. To study the mechanical behaviour of individual components of the IVD, it is common for specimens to be dissected away from their surrounding tissues for mechanical testing. However, disrupting the continuity of the IVD to obtain material properties of each component separately may result in erroneous values. In this study, an inverse finite element (FE) modelling optimisation algorithm has been used to obtain material properties of the IVD across strain rates, therefore bypassing the need to harvest individual samples of each component. Uniaxial compression was applied to ten fresh-frozen bovine intervertebral discs at strain rates of 10-3–1/s. The experimental data were fed into the inverse FE optimisation algorithm and each experiment was simulated using the subject specific FE model of the respective specimen. A sensitivity analysis revealed that the IVD's response was most dependent upon the Young's modulus (YM) of the fibre bundles and therefore this was chosen to be the parameter to optimise. Based on the obtained YM values for each test corresponding to a different strain rate (View the MathML source), the following relationship was derived:View the MathML source. These properties can be used in finite element models of the IVD that aim to simulate spinal biomechanics across loading rates.
AU  - Newell,N
AU  - Grigoriadis,G
AU  - Christou,A
AU  - Carpanen,D
AU  - Masouros,S
DO  - 10.1016/j.jmbbm.2016.10.012
EP  - 830
PY  - 2017///
SN  - 1751-6161
SP  - 824
TI  - Material properties of bovine intervertebral discs across strain rates
T2  - Journal of The Mechanical Behavior of Biomedical Materials
UR  - http://dx.doi.org/10.1016/j.jmbbm.2016.10.012
UR  - https://www.sciencedirect.com/science/article/pii/S1751616116303654
UR  - http://hdl.handle.net/10044/1/43873
VL  - 65
ER  -
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