Publications
246 results found
Nicholas HB, Arst HN, Caddick MX, 2001, Evaluating low level sequence identities -: Are <i>Aspergillus</i> QUTA and AROM homologous?, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 268, Pages: 414-419, ISSN: 0014-2956
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- Citations: 3
Denison SH, Negrete-Urtasun S, Mingot JM, et al., 2001, Putative membrane components of signal transduction pathways for ambient pH regulation in <i>Aspergillus</i> and meiosis in <i>Saccharomyces</i> are homologous (vol 30, pg 259, 1998), MOLECULAR MICROBIOLOGY, Vol: 39, Pages: 211-211, ISSN: 0950-382X
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- Citations: 3
Brown JS, Aufauvre-Brown A, Brown J, et al., 2000, Signature-tagged and directed mutagenesis identify PABA synthetase as essential for <i>Aspergillus fumigatus</i> pathogenicity, MOLECULAR MICROBIOLOGY, Vol: 36, Pages: 1371-1380, ISSN: 0950-382X
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- Citations: 111
Espeso EA, Roncal T, Díez E, et al., 2000, On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction, EMBO JOURNAL, Vol: 19, Pages: 2391-2391, ISSN: 0261-4189
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- Citations: 1
Espeso EA, Arst HN, 2000, On the mechanism by which alkaline pH prevents expression of an acid-expressed gene, MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 3355-3363, ISSN: 0270-7306
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- Citations: 83
Espeso EA, Roncal T, Díez E, et al., 2000, On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction, EMBO JOURNAL, Vol: 19, Pages: 719-728, ISSN: 0261-4189
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- Citations: 47
Arst HN, 2000, Apathy rewards misconduct - and everybody suffers, NATURE, Vol: 403, Pages: 478-478, ISSN: 0028-0836
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- Citations: 1
Negrete-Urtasun S, Reiter W, Diez E, et al., 1999, Ambient pH signal transduction in <i>Aspergillus</i>:: completion of gene characterization (vol 33, pg 994, 1999), MOLECULAR MICROBIOLOGY, Vol: 34, Pages: 1149-1149, ISSN: 0950-382X
Negrete-Urtasun S, Reiter W, Diez E, et al., 1999, Ambient pH signal transduction in <i>Aspergillus</i>:: completion of gene characterization, MOLECULAR MICROBIOLOGY, Vol: 33, Pages: 994-1003, ISSN: 0950-382X
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- Citations: 86
Hutchings H, Stahmann KP, Roels S, et al., 1999, The multiply-regulated <i>gabA</i> gene encoding the GABA permease of <i>Aspergillus nidulans</i>:: a score of exons, MOLECULAR MICROBIOLOGY, Vol: 32, Pages: 557-568, ISSN: 0950-382X
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- Citations: 38
Mingot JM, Tilburn J, Diez E, et al., 1999, Specificity determinants of proteolytic processing of <i>Aspergillus</i> PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassed, MOLECULAR AND CELLULAR BIOLOGY, Vol: 19, Pages: 1390-1400, ISSN: 0270-7306
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- Citations: 64
Caddick MX, Arst HN, 1998, Deletion of the 389 N-terminal residues of the transcriptional activator AREA does not result in nitrogen metabolite derepression in <i>Aspergillus nidulans</i>, JOURNAL OF BACTERIOLOGY, Vol: 180, Pages: 5762-5764, ISSN: 0021-9193
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- Citations: 18
Denison SH, Negrete-Urtasun S, Mingot JR, et al., 1998, Putative membrane components of signal transduction pathways for ambient pH regulation in <i>Aspergillus</i> and meiosis in <i>Saccharomyces</i> are homologous, MOLECULAR MICROBIOLOGY, Vol: 30, Pages: 259-264, ISSN: 0950-382X
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- Citations: 55
Wilson RA, Arst HN, 1998, Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors., Microbiol Mol Biol Rev, Vol: 62, Pages: 586-596, ISSN: 1092-2172
The transcriptional activator AREA is a member of the GATA family of transcription factors and mediates nitrogen metabolite repression in the fungus Aspergillus nidulans. The nutritional versatility of A. nidulans and its amenability to classical and reverse genetic manipulations make the AREA DNA binding domain (DBD) a useful model for analyzing GATA family DBDs, particularly as structures of two AREA-DNA complexes have been determined. The 109 extant mutant forms of the AREA DBD surveyed here constitute one of the highest totals of eukaryotic transcription factor DBD mutants, are discussed in light of the roles of individual residues, and are compared to corresponding mutant sequence changes in other fungal GATA factor DBDs. Other topics include delineation of the DBD using both homology and mutational truncation, use of frameshift reversion to detect regions of tolerance to mutational change, the finding that duplication of the DBD can apparently enhance AREA function, and use of the AREA system to analyze a vertebrate GATA factor DBD. Some major points to emerge from work on the AREA DBD are (i) tolerance to sequence change (with retention of function) is surprisingly great, (ii) mutational changes in a transcription factor can have widely differing, even opposing, effects on expression of different structural genes so that monitoring expression of one or even several structural genes can be insufficient and possibly misleading, and (iii) a mutational change altering local hydrophobic packing and DNA binding target specificity can markedly influence the behavior of mutational changes elsewhere in the DBD.
Wilson RA, Arst HN, 1998, Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in <i>Aspergillus nidulans</i> and a member of the "streetwise" GATA family of transcription factors, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 62, Pages: 586-+, ISSN: 1092-2172
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- Citations: 96
Hensel M, Arst HN, Aufauvre-Brown A, et al., 1998, The role of the <i>Aspergillus fumigatus areA</i> gene in invasive pulmonary aspergillosis, MOLECULAR AND GENERAL GENETICS, Vol: 258, Pages: 553-557, ISSN: 0026-8925
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- Citations: 77
Starich MR, Wikström M, Schumacher S, et al., 1998, The solution structure of the Leu22→Val mutant AREA DNA binding domain complexed with a TGATAG core element defines a role for hydrophobic packing in the determination of specificity, JOURNAL OF MOLECULAR BIOLOGY, Vol: 277, Pages: 621-634, ISSN: 0022-2836
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- Citations: 33
Starich MR, Wikström M, Arst HN, et al., 1998, The solution structure of a fungal AREA protein-DNA complex:: An alternative binding mode for the basic carboxyl tail of GATA factors, JOURNAL OF MOLECULAR BIOLOGY, Vol: 277, Pages: 605-620, ISSN: 0022-2836
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- Citations: 59
MacCabe AP, Vanhanen S, Gelpke MDS, et al., 1998, Identification, cloning and sequence of the <i>Aspergillus niger areA</i> wide domain regulatory gene controlling nitrogen utilisation, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, Vol: 1396, Pages: 163-168, ISSN: 0167-4781
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- Citations: 17
Espeso EA, Tilburn J, Sánchez-Pulido L, et al., 1997, Specific DNA recognition by the <i>Aspergillus nidulans</i> three zinc finger transcription factor PacC, JOURNAL OF MOLECULAR BIOLOGY, Vol: 274, Pages: 466-480, ISSN: 0022-2836
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- Citations: 95
Arst HN, Holden DW, Caddick MX, 1997, Evolution of transcription-regulating proteins: caveat lector!, GENE, Vol: 173, Pages: S1-S4, ISSN: 0378-1119
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- Citations: 1
Ravagnani A, Gorfinkiel L, Langdon T, et al., 1997, Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA, EMBO JOURNAL, Vol: 16, Pages: 3974-3986, ISSN: 0261-4189
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- Citations: 134
Arst HN, 1997, New evidence for old detective work, MICROBIOLOGY-UK, Vol: 143, Pages: 1481-1482, ISSN: 1350-0872
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- Citations: 4
Arst HN, 1997, Cosying up to MoCo, MICROBIOLOGY-UK, Vol: 143, Pages: 1037-1037, ISSN: 1350-0872
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- Citations: 1
NegreteUrtasun S, Denison SH, Arst HN, 1997, Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologs, JOURNAL OF BACTERIOLOGY, Vol: 179, Pages: 1832-1835, ISSN: 0021-9193
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- Citations: 82
Arst HN, Sheerins A, 1996, Erratum: Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (Molecular Microbiology (1996) 19 (5), 1019-1024), Molecular Microbiology, Vol: 20, ISSN: 0950-382X
Sarkar S, Caddick MX, Bignell E, et al., 1996, Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acid pH, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 24, Pages: 360-363, ISSN: 0300-5127
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- Citations: 31
Arst HN, Sheerins A, 1996, Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (vol 19, pg 1019, 1996), MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 901-901, ISSN: 0950-382X
Langdon T, Sheerins A, Ravagnani A, et al., 1996, Erratum: Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (Mol Microbiol. (1995), 17 (5), 877-888), Molecular Microbiology, Vol: 20, ISSN: 0950-382X
Langdon T, Sheerins A, Ravagnani A, et al., 1996, Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (vol 17, pg 877, 1995), MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 239-239, ISSN: 0950-382X
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- Citations: 1
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