Imperial College London
Alternate

DrHutanAshrafian

Faculty of Medicine, Department of Surgery & Cancer

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3312 7651h.ashrafian

 
 
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Location

 

1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fletcher:2022:gastro/goac042,
author = {Fletcher, E and Thompson, A and Ashrafian, H and Darzi, A},
doi = {gastro/goac042},
journal = {Gastroenterology Report},
pages = {1--13},
title = {The measurement and modification of hypoxia in colorectal cancer: overlooked but not forgotten},
url = {http://dx.doi.org/10.1093/gastro/goac042},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tumour hypoxia is the inevitable consequence of a tumour’s rapid growth and disorganised, inefficient vasculature. The compensatory mechanisms employed by tumours, and indeed the absence of oxygen itself, hinder the ability of all treatment modalities. The clinical consequence is poorer overall survival, disease-free survival, and locoregional control. Recognising this, clinicians have been attenuating the effect of hypoxia, primarily with hypoxic modification or with hypoxia activated pro-drugs, and notable success has been demonstrated. However, in the case of colorectal cancer (CRC), there is a general paucity of knowledge and evidence surrounding the measurement and modification of hypoxia, and this is possibly due to the comparative inaccessibility of such tumours. We specifically review the role of hypoxia in CRC, and focus on:  the current evidence for the existence of hypoxia in CRC, the majority of which originates from indirect positron emission topography (PET) imaging with hypoxia selective radiotracers; the evidence correlating CRC hypoxia with poorer oncological outcome, which is largely based on the measurement of Hypoxia Inducible Factor (HIF)  in correlation with clinical outcome; the evidence of hypoxic modification in CRC, of which no direct evidence exists, but is reflected in a number of indirect markers; the prognostic and monitoring implications of accurate CRC hypoxia quantification and its potential in the field of precision oncology; and the present and future imaging tools and technologies being developed for the measurement of CRC hypoxia, including the use of blood oxygen level dependent (BOLD) MRI imaging and diffuse reflectance spectroscopy.
AU  - Fletcher,E
AU  - Thompson,A
AU  - Ashrafian,H
AU  - Darzi,A
DO  - gastro/goac042
EP  - 13
PY  - 2022///
SN  - 2052-0034
SP  - 1
TI  - The measurement and modification of hypoxia in colorectal cancer: overlooked but not forgotten
T2  - Gastroenterology Report
UR  - http://dx.doi.org/10.1093/gastro/goac042
UR  - http://hdl.handle.net/10044/1/98565
VL  - 10
ER  -
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