Dr. Hakan Bagci is a postdoctoral researcher at the Faculty of Medicine Institute of Clinical Sciences, with expertise in molecular and cellular biology.
During his Ph.D. studies at Imperial College London (supervised by Professor Amanda Fisher), Dr. Bagci investigated the roles of DNA methylation in epigenetic reprogramming, and signalling pathways involved in stem cell renewal and differentiation.
Dr. Bagci currently studies the roles of three dimensional chromatin reorganisation in the regulation of gene expression, under the supervision of Professor Matthias Merkenschlager. He is particularly interested in the cohesin protein complex, and has been using a range of molecular techniques, including epigenetics tools and CRISPR/Cas9-based genetic engineering, in in vitro and in vivo models, to delineate cohesin's functions.
In addition to his academic research, Dr. Bagci worked as a consultant with biotechnology and pharmaceutical companies, and is the founder and committee member of the Imperial Postdocs and Fellows Enterprise Network, a network of early career researchers that aims to raise awareness of opportunities in business and science-based entrepreneurship.
et al., 2018, Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte, Nature, Vol:555, ISSN:0028-0836, Pages:392-396
Fisher AG, 2016, Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming, Nature Communications, Vol:7, ISSN:2041-1723
et al., 2016, A microfluidic toolbox for cell fusion, Journal of Chemical Technology and Biotechnology, Vol:91, ISSN:1097-4660, Pages:16-24
et al., 2015, Jarid2 coordinates nanog expression and PCP/Wnt signaling required for efficient ESC differentiation and early embryo development, Cell Reports, Vol:12, ISSN:2211-1247, Pages:573-586
et al., 2013, Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs, Cell Cycle, Vol:12, ISSN:1538-4101, Pages:3253-3261
Bagci H, Fisher AG, 2013, DNA Demethylation in Pluripotency and Reprogramming: The Role of Tet Proteins and Cell Division, Cell Stem Cell, Vol:13, ISSN:1934-5909, Pages:265-269
et al., 2013, Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion, Molecular Cell, Vol:49, ISSN:1097-2765, Pages:1023-1033
et al., 2013, DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion, Cell, Vol:152, ISSN:0092-8674, Pages:873-883