Imperial College London

Dr Henrietta Bowden-Jones OBE FRCPsych, BA(Hons), DOccMed, MD(Imperial)

Faculty of MedicineFaculty of Medicine Centre

Honorary Clinical Senior Lecturer



+44 (0)20 7381 7722h.bowdenjones02




National Problem Gambling ClinicCharing Cross HospitalCharing Cross Campus






BibTex format

author = {Djamshidian, A and O'Sullivan, SS and Sanotsky, Y and Sharman, S and Matviyenko, Y and Foltynie, T and Michalczuk, R and Aviles-Olmos, I and Fedoryshyn, L and Doherty, KM and Filts, Y and Selikhova, M and Bowden-Jones, H and Joyce, E and Lees, AJ and Averbeck, BB},
doi = {10.1002/mds.25105},
journal = {Mov Disord},
pages = {1137--1145},
title = {Decision making, impulsivity, and addictions: do Parkinson's disease patients jump to conclusions?},
url = {},
volume = {27},
year = {2012}

RIS format (EndNote, RefMan)

AB - Links between impulsive-compulsive behaviors (ICBs) in treated Parkinson's disease (PD), behavioral addictions, and substance abuse have been postulated, but no direct comparisons have been carried out so far. We directly compared patients with PD with and without ICBs with illicit drug abusers, pathological gamblers, and age-matched healthy controls using the beads task, a test of reflection impulsivity, and a working memory task. We found that all patients with PD made more impulsive and irrational choices than the control group. PD patients who had an ICB showed similar behavior to illicit substance abusers, whereas patients without ICBs more closely resembled pathological gamblers. In contrast, we found no difference in working memory performance within the PD groups. However, PD patients without ICBs remembered distractors significantly less than all other patients during working memory tests. We were able to correctly classify 96% of the PD patients with respect to whether or not they had an ICB by analyzing three trials of the 80/20 loss condition of the beads task with a negative prediction value of 92.3%, and we propose that this task may prove to be a powerful screening tool to detect an ICB in PD. Our results also suggest that intact cortical processing and less distractibility in PD patients without ICBs may protect them from developing behavioral addictions.
AU - Djamshidian,A
AU - O'Sullivan,SS
AU - Sanotsky,Y
AU - Sharman,S
AU - Matviyenko,Y
AU - Foltynie,T
AU - Michalczuk,R
AU - Aviles-Olmos,I
AU - Fedoryshyn,L
AU - Doherty,KM
AU - Filts,Y
AU - Selikhova,M
AU - Bowden-Jones,H
AU - Joyce,E
AU - Lees,AJ
AU - Averbeck,BB
DO - 10.1002/mds.25105
EP - 1145
PY - 2012///
SP - 1137
TI - Decision making, impulsivity, and addictions: do Parkinson's disease patients jump to conclusions?
T2 - Mov Disord
UR -
UR -
VL - 27
ER -