Imperial College London
Mrs Hanna Box, MPH - Global Health

Mrs Hanna Box, MPH - Global Health

Faculty of Medicine, School of Public Health

Operations Manager - Clinical Research
 
 
 
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Contact

 

h.box

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2021:10.1016/j.celrep.2021.109103,
author = {Yang, H and Llano, A and Cedeno, S and von, Delft A and Corcuera, A and Gillespie, GM and Knox, A and Leneghan, DB and Frater, J and Stohr, W and Fidler, S and Mothe, B and Mak, J and Brander, C and Ternette, N and Dorrell, L},
doi = {10.1016/j.celrep.2021.109103},
journal = {Cell Reports},
title = {Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8(+) T cell antiviral responses},
url = {http://dx.doi.org/10.1016/j.celrep.2021.109103},
volume = {35},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Persistence of HIV through integration into host DNA in CD4+ T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8+ T cells are triggered to kill infected CD4+ T cells through recognition of histocompatibility leukocyte antigen (HLA) class I-bound peptides derived from incoming virions. However, this has been reported only in individuals with “beneficial” HLA alleles that are associated with superior HIV control. Through interrogation of the pre-integration immunopeptidome, we obtain proof of early presentation of a virion-derived HLA-A∗02:01-restricted epitope, FLGKIWPSH (FH9), located in Gag Spacer Peptide 2 (SP2). FH9-specific CD8+ T cell responses are detectable in individuals with primary HIV infection and eliminate HIV-infected CD4+ T cells prior to virus production in vitro. Our data show that non-beneficial HLA class I alleles can elicit an effective antiviral response through early presentation of HIV virion-derived epitopes and also demonstrate the importance of SP2 as an immune target.
AU  - Yang,H
AU  - Llano,A
AU  - Cedeno,S
AU  - von,Delft A
AU  - Corcuera,A
AU  - Gillespie,GM
AU  - Knox,A
AU  - Leneghan,DB
AU  - Frater,J
AU  - Stohr,W
AU  - Fidler,S
AU  - Mothe,B
AU  - Mak,J
AU  - Brander,C
AU  - Ternette,N
AU  - Dorrell,L
DO  - 10.1016/j.celrep.2021.109103
PY  - 2021///
SN  - 2211-1247
TI  - Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8(+) T cell antiviral responses
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2021.109103
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000649197800012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00437-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112472100437X%3Fshowall%3Dtrue#articleInformation
UR  - http://hdl.handle.net/10044/1/92822
VL  - 35
ER  -
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