Publications
78 results found
Ruiz A, Williams O, Brady HJM, 2008, The Ikaros splice isoform, Ikaros 6, immortalizes murine haematopoietic progenitor cells, INTERNATIONAL JOURNAL OF CANCER, Vol: 123, Pages: 1240-1245, ISSN: 0020-7136
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- Citations: 9
Izraeli S, Salek-Ardakani S, De Boer J, et al., 2008, THE LEUKEMOGENIC TRANSCRIPTION FACTOR ERG COLLABORATES WITH GATA1S TO IMMORTALIZE MEGAKAROCYTIC PRECURSORS: A MOUSE MODEL FOR THE PATHOGENESIS OF SPORADIC AND DOWN SYNDROME ASSOCIATED ACUTE MEGAKARYOBLASTIC LEUKEMIAS, Publisher: FERRATA STORTI FOUNDATION, Pages: 187-187, ISSN: 0390-6078
Crescenzi E, Palumbo G, de Boer J, et al., 2008, Ataxia telangiectasia mutated and p21<SUP>CIP1</SUP> modulate cell survival of drug-induced senescent tumor cells:: Implications for chemotherapy, CLINICAL CANCER RESEARCH, Vol: 14, Pages: 1877-1887, ISSN: 1078-0432
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- Citations: 64
Chowdhury T, Brady HJM, 2007, Insights from clinical studies into the role of the <i>MLL</i> gene in infant and childhood leukemia, BLOOD CELLS MOLECULES AND DISEASES, Vol: 40, Pages: 192-199, ISSN: 1079-9796
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- Citations: 36
McMahon KA, Hiew SY-L, Hadjur S, et al., 2007, MII has a critical role in fetal and adult hematopoietic stem cell self-renewal, CELL STEM CELL, Vol: 1, Pages: 338-345, ISSN: 1934-5909
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- Citations: 207
Morrow M, Samanta A, Kioussis D, et al., 2007, TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL, ONCOGENE, Vol: 26, Pages: 4404-4414, ISSN: 0950-9232
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- Citations: 31
Rossi AG, Sawatzky DA, Walker A, et al., 2006, Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis (vol 12, pg 1056, 2006), NATURE MEDICINE, Vol: 12, Pages: 1434-1434, ISSN: 1078-8956
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- Citations: 6
Rossi AG, Sawatzky DA, Walker A, et al., 2006, Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis, NATURE MEDICINE, Vol: 12, Pages: 1056-1064, ISSN: 1078-8956
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- Citations: 405
Zhuang J, Brady HJM, 2006, Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis, CELL DEATH AND DIFFERENTIATION, Vol: 13, Pages: 1263-1267, ISSN: 1350-9047
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- Citations: 21
Meyer C, Schneider B, Jakob S, et al., 2006, The MLL recombinome of acute leukemias, LEUKEMIA, Vol: 20, Pages: 777-784, ISSN: 0887-6924
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- Citations: 159
Clohessy JG, Zhuang JG, de Boer J, et al., 2006, Mcl-1 interacts with truncated bid and inhibits its induction of cytochrome <i>c</i> release and its role in receptor-mediated apoptosis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 5750-5759
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- Citations: 151
Yeung J, Kempski H, Neat M, et al., 2006, Characterization of the t(17;19) translocation by gene-specific fluorescent <i>in situ</i> hybridization-based cytogenetics and detection of the <i>E2A</i>-<i>HLF</i> fusion transcript and protein in patients' cells, HAEMATOLOGICA, Vol: 91, Pages: 422-424, ISSN: 0390-6078
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- Citations: 13
Yeung J, Kempski H, Neat M, et al., 2006, Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 91, Pages: 422-424, ISSN: 0390-6078
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- Citations: 1
Hughes TA, Brady HJM, 2006, Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer, CANCER LETTERS, Vol: 233, Pages: 338-347, ISSN: 0304-3835
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- Citations: 28
Crescenzi E, Palumbo G, Brady HJM, 2005, Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy., Clin Cancer Res, Vol: 11, Pages: 8158-8171, ISSN: 1078-0432
PURPOSE: Treatment of tumor cells by chemotherapy activates a series of responses ranging from apoptosis to premature senescence and repair. Survival responses are characterized by inhibition of cyclin-dependent kinases. Because inhibition of cyclin-dependent kinases represents a distinctive feature of DNA damage-induced prosurvival responses, we investigated the possibility that the cyclin-dependent kinase inhibitor roscovitine modulates drug-induced responses in human adenocarcinoma cells, favoring cell survival. EXPERIMENTAL DESIGN: Sublethal concentrations of doxorubicin were used to induce premature senescence in human adenocarcinoma cells. The effect of the cyclin-dependent kinase inhibitor roscovitine on the doxorubicin-dependent cell cycle checkpoint activation and DNA repair pathways was evaluated. RESULTS: Roscovitine reinforces doxorubicin-dependent G(1) checkpoint in A549 and HEC1B cells leading to decreased frequency of double-strand breaks and to the preferential induction of senescence and enhanced clonogenic survival. However, in other tumor cell lines, such as HCT116 and H1299, combined treatment with doxorubicin and roscovitine increases the frequency of double-strand breaks and dramatically sensitizes to doxorubicin. This unexpected effect of roscovitine depends on a novel ability to inhibit DNA double-strand break repair processes and requires inactivation of the pRb pathway. CONCLUSIONS: Roscovitine, by hindering DNA repair processes, has the potential to inhibit recovery of mildly damaged tumor cells after doxorubicin treatment and to increase the susceptibility of tumor cells to chemotherapy. However, in some tumor cells, the cell cycle inhibitory function of roscovitine prevails over the DNA repair inhibitory activity, favoring premature senescence and clonogenic growth. These data indicate a novel mechanism underlying combined chemotherapy, which may have wide application in treatment of carcinomas.
Horton SJ, Grier DG, McGonigle GJ, et al., 2005, Continuous MLL-ENL expression is necessary to establish a "Hox code" and maintain immortalization of hematopoietic progenitor cells, CANCER RESEARCH, Vol: 65, Pages: 9245-9252, ISSN: 0008-5472
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- Citations: 59
Smyth LA, Brady HJM, 2005, cMet and fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells, HYPERTENSION, Vol: 46, Pages: 100-106, ISSN: 0194-911X
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- Citations: 21
Hughes TA, Brady HJM, 2005, E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 329, Pages: 1267-1274, ISSN: 0006-291X
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- Citations: 15
Hughes TA, Brady HJM, 2005, Expression of axin2 is regulated by the alternative 5′-untranslated regions of its mRNA, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 8581-8588
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- Citations: 26
Hughes TA, Brady HJM, 2005, Cross-talk between pRb/E2F and Wnt/β-catenin pathways:: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death, EXPERIMENTAL CELL RESEARCH, Vol: 303, Pages: 32-46, ISSN: 0014-4827
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- Citations: 37
Granés F, Roig MB, Brady HJM, et al., 2004, Cdk2 activation acts upstream of the mitochondrion during glucocorticoid induced thymocyte apoptosis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 34, Pages: 2781-2790, ISSN: 0014-2980
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- Citations: 22
Clohessy JG, Zhuang JG, Brady HJM, 2004, Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 125, Pages: 655-665, ISSN: 0007-1048
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- Citations: 67
Yeung J, O'Sullivan E, Hubank M, et al., 2004, E4BP4 expression is regulated by the t(17;19)-associated oncoprotein E2A-HLF in pro-B cells, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 125, Pages: 560-567, ISSN: 0007-1048
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- Citations: 8
Morrow M, Horton S, Kioussis D, et al., 2004, TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity, BLOOD, Vol: 103, Pages: 3890-3896, ISSN: 0006-4971
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- Citations: 76
Ruiz A, Jiang J, Kempski H, et al., 2004, Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 125, Pages: 31-37, ISSN: 0007-1048
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- Citations: 28
Brady HJM, 2003, Apoptosis and leukaemia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 123, Pages: 577-585, ISSN: 0007-1048
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- Citations: 11
Crescenzi E, Palumbo G, Brady HJM, 2003, Bcl-2 activates a programme of premature senescence in human carcinoma cells, BIOCHEMICAL JOURNAL, Vol: 375, Pages: 263-274, ISSN: 0264-6021
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- Citations: 50
Williams O, Mok CL, Norton T, et al., 2001, Elevated Bcl-2 is not a causal event in the positive selection of T cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 31, Pages: 1876-1882, ISSN: 0014-2980
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- Citations: 7
Williams O, Brady HJM, 2001, The role of molecules that mediate apoptosis in T-cell selection, TRENDS IN IMMUNOLOGY, Vol: 22, Pages: 107-111, ISSN: 1471-4906
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- Citations: 17
Williams O, Gil-Gómez G, Norton T, et al., 2000, Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 30, Pages: 709-713, ISSN: 0014-2980
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- Citations: 14
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