Imperial College London
Alternate

Professor Hugh JM Brady

Faculty of Natural Sciences, Department of Life Sciences

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3777h.brady Website

 
 
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Location

 

504Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Doisne:2015:10.4049/jimmunol.1500689,
author = {Doisne, J-M and Balmas, E and Boulenouar, S and Gaynor, LM and Kieckbusch, J and Gardner, L and Hawkes, DA and Barbara, CF and Sharkey, AM and Brady, HJM and Brosens, JJ and Moffett, A and Colucci, F},
doi = {10.4049/jimmunol.1500689},
journal = {Journal of Immunology},
pages = {3937--3945},
title = {Composition, Development, and Function of Uterine Innate Lymphoid Cells},
url = {http://dx.doi.org/10.4049/jimmunol.1500689},
volume = {195},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. In this article, we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua during early pregnancy. Whereas nonkiller uILC1s and uILC2s are barely detectable in mouse and not detected in humans, a sizeable population of uILC3s is found in human endometrium and decidua, which are mostly NCR+ and partially overlap with previously described IL-22–producing uterine NK cells. Development of mouse uILC3 is Nfil3 independent, suggesting unique features of uILCs. Indeed, although the cytokine production profile of mouse uILCs recapitulates that described in other tissues, IL-5, IL-17, and IL-22 are constitutively produced by uILC2s and uILC3s. This study lays the foundation to understand how ILCs function in the specialized uterine mucosa, both in tissue homeostasis and barrier immunity and during pregnancy.
AU  - Doisne,J-M
AU  - Balmas,E
AU  - Boulenouar,S
AU  - Gaynor,LM
AU  - Kieckbusch,J
AU  - Gardner,L
AU  - Hawkes,DA
AU  - Barbara,CF
AU  - Sharkey,AM
AU  - Brady,HJM
AU  - Brosens,JJ
AU  - Moffett,A
AU  - Colucci,F
DO  - 10.4049/jimmunol.1500689
EP  - 3945
PY  - 2015///
SN  - 0022-1767
SP  - 3937
TI  - Composition, Development, and Function of Uterine Innate Lymphoid Cells
T2  - Journal of Immunology
UR  - http://dx.doi.org/10.4049/jimmunol.1500689
UR  - http://hdl.handle.net/10044/1/37470
VL  - 195
ER  -
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