Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Microbiology



+44 (0)20 7594 5383h.d.williams




507Sir Alexander Fleming BuildingSouth Kensington Campus






We are focused on understanding the physiology of bacterial pathogens in relation to chronic infection. We study the mechanisms by which bacteria sense starvation stress, shut down metabolism and maintain cell integrity to enter into a persistent state within the context of chronic infections. 

We employ an eclectic mix of approaches including molecular genetics, mutational studies, transcriptomic and metabolomics approaches, targeted proteomics and flow cytometry as well as in vitro characterisation of proteins.

Our research is in two main disease areas:

1.     Tuberculosis.

2.     Infections of the Cystic Fibrosis Lung

Selected Publications

Journal Articles

Behrends V, Ryall B, Zlosnik JEA, et al., 2013, Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections, Environmental Microbiology, Vol:15, ISSN:1462-2912, Pages:398-408

Behrends V, Ryall B, Zlosnik JEA, et al., 2012, Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis lung infections, International Journal of Medical Microbiology, Vol:302, ISSN:1438-4221, Pages:109-109

Trauner A, Lougheed KEA, Bennett MH, et al., 2012, The dormancy regulator DosR controls ribosome stability in hypoxic mycobacteria, Journal of Biological Chemistry, Vol:287, ISSN:0021-9258, Pages:24053-24063

Williams HD, Davies JC, 2012, Basic science for the chest physician: <i>Pseudomonas aeruginosa</i> and the cystic fibrosis airway, Thorax, Vol:67, ISSN:0040-6376, Pages:465-467

Behrends V, Ryall B, Wang X, et al., 2010, Metabolic profiling of <i>Pseudomonas</i> <i>aeruginosa</i> demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance, Molecular Biosystems, Vol:6, ISSN:1742-206X, Pages:562-569

Ryall B, Davies JC, Wilson R, et al., 2008, <i>Pseudomonas aeruginosa</i>, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients, European Respiratory Journal, Vol:32, ISSN:0903-1936, Pages:740-747

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