Publications
198 results found
Perez-Trujillo M, Lindon JC, Parella T, et al., 2012, Chiral Metabonomics: <SUP>1</SUP>H NMR-Based Enantiospecific Differentiation of Metabolites in Human Urine via Direct Cosolvation with β-Cyclodextrin, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 2868-2874, ISSN: 0003-2700
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- Citations: 29
Benton HP, Want E, Keun HC, et al., 2012, Intra- and Interlaboratory Reproducibility of Ultra Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry for Urinary Metabolic Profiling, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 2424-2432, ISSN: 0003-2700
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- Citations: 36
Nunes J, Naymark M, Sauer L, et al., 2012, Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection, BRITISH JOURNAL OF CANCER, Vol: 106, Pages: 909-915, ISSN: 0007-0920
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- Citations: 47
Ellis JK, Athersuch TJ, Thomas LD, et al., 2012, Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population., BMC medicine, Vol: 10, Pages: 61-61
Spurgeon DJ, Lawlor A, Hooper HL, et al., 2011, Outdoor and indoor cadmium distributions near an abandoned smelting works and their relations to human exposure, ENVIRONMENTAL POLLUTION, Vol: 159, Pages: 3425-3432, ISSN: 0269-7491
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- Citations: 12
Kamburov A, Cavill R, Ebbels TMD, et al., 2011, Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA, BIOINFORMATICS, Vol: 27, Pages: 2917-2918, ISSN: 1367-4803
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- Citations: 268
Teichert F, Winkler S, Keun HC, et al., 2011, Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 25, Pages: 2071-2082, ISSN: 0951-4198
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- Citations: 14
Teahan O, Bevan CL, Waxman J, et al., 2011, Metabolic signatures of malignant progression in prostate epithelial cells, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Vol: 43, Pages: 1002-1009, ISSN: 1357-2725
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- Citations: 40
Ellis JK, Athersuch TJ, Cavill R, et al., 2011, Erratum: Metabolic response to low level toxicant exposure in a novel renal tubule epithelial cell system (Molecular BioSystems (2010) DOI:10.1039/c0mb00146e), Molecular BioSystems, Vol: 7, Pages: 2081-2086, ISSN: 1742-206X
Stebbing J, Sharma A, North B, et al., 2011, A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumor responses to chemotherapy., J Clin Oncol, Vol: 29
10544 Background: Breast cancer is associated with adverse outcomes in patients with the metabolic syndrome phenotype. We previously demonstrated using a metabolic profiling (metabonomics) approach that glucose, lactate and alanine levels were perturbed during chemotherapy and that these effects were associated with weight gain during treatment. To validate these data and study this further, we examined the relationship between serum metabolite levels and the components of metabolic syndrome with treatment outcomes in breast cancer. METHODS: A total of 88 women with measurable breast cancer were studied; their serum metabolites as assessed by 1H NMR spectroscopy, blood pressure, lipids, glucose, body mass index and waist circumference were recorded and correlated with treatment response. RESULTS: We identified metabolic syndrome in approximately half of our cohort (42 patients) and observed a significant trend (p=0.03) of increased incidence of metabolic syndrome in partial response (33.3%), stable disease (42.9%) and progressive disease groups (66.1%). Of the components of metabolic syndrome, high blood sugar predicted a poor response (p < 0.001). Logistic regression of metabonomic data demonstrated that high lactate (p=0.03) and low alanine (p=0.01), combined with high glucose (p=0.01) in the same sera, were associated with disease progression. CONCLUSIONS: Metabolic syndrome is commonly observed in women with metastatic breast cancer and these patients have poorer outcomes. These data, which support our previous findings suggest that high blood glucose as part of metabolic syndrome is associated with a poor response in breast cancer. They also validate new therapeutic approaches that focus on metabolism.
Backshall A, Sharma R, Clarke SJ, et al., 2011, Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine, CLINICAL CANCER RESEARCH, Vol: 17, Pages: 3019-3028, ISSN: 1078-0432
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- Citations: 87
Primrose S, Draper J, Elsom R, et al., 2011, Metabolomics and human nutrition., Br J Nutr, Vol: 105, Pages: 1277-1283
The present report summarises a workshop convened by the UK Food Standards Agency (Agency) on 25 March 2010 to discuss the current Agency's funded research on the use of metabolomics technologies in human nutrition research. The objectives of this workshop were to review progress to date, to identify technical challenges and ways of overcoming them, and to discuss future research priorities and the application of metabolomics in public health nutrition research and surveys. Results from studies nearing completion showed that by using carefully designed dietary and sampling regimens, it is possible to identify novel biomarkers of food intake that could not have been predicted from current knowledge of food composition. These findings provide proof-of-principle that the metabolomics approach can be used to develop new putative biomarkers of dietary intake. The next steps will be to validate these putative biomarkers, to develop rapid and inexpensive assays for biomarkers of food intake of high public health relevance, and to test their utility in population cohort studies and dietary surveys.
Cavill R, Kamburov A, Ellis JK, et al., 2011, Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells, PLOS COMPUTATIONAL BIOLOGY, Vol: 7, ISSN: 1553-734X
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- Citations: 72
Chadeau-Hyam M, Athersuch TJ, Keun HC, et al., 2011, Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies, BIOMARKERS, Vol: 16, Pages: 83-88, ISSN: 1354-750X
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- Citations: 89
Keun HC, Athersuch TJ, 2011, Nuclear Magnetic Resonance (NMR)-Based Metabolomics, METABOLIC PROFILING: METHODS AND PROTOCOLS, Editors: Metz, Publisher: HUMANA PRESS INC, Pages: 321-334, ISBN: 978-1-61737-984-0
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- Citations: 33
Ellis JK, Athersuch TJ, Cavill R, et al., 2011, Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system, MOLECULAR BIOSYSTEMS, Vol: 7, Pages: 247-257, ISSN: 1742-206X
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- Citations: 46
Ellis JK, Athersuch TJ, Cavill R, et al., 2011, Metabolic response to low level toxicant exposure in a novel renal tubule epithelial cell system (vol 7, pg 247, 2011), MOLECULAR BIOSYSTEMS, Vol: 7, Pages: 2081-2086, ISSN: 1742-206X
Yakoub D, Keun HC, Goldin R, et al., 2010, Metabolic Profiling Detects Field Effects in Nondysplastic Tissue from Esophageal Cancer Patients, CANCER RESEARCH, Vol: 70, Pages: 9129-9136, ISSN: 0008-5472
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- Citations: 37
Pchejetski D, Nunes J, Sauer L, et al., 2010, Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer, BREAST CANCER RESEARCH AND TREATMENT, Vol: 124, Pages: 543-549, ISSN: 0167-6806
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- Citations: 6
Lauridsen MB, Bliddal H, Christensen R, et al., 2010, <SUP>1</SUP>H NMR Spectroscopy-Based Interventional Metabolic Phenotyping: A Cohort Study of Rheumatoid Arthritis Patients, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 4545-4553, ISSN: 1535-3893
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- Citations: 77
Want EJ, Coen M, Masson P, et al., 2010, Ultra Performance Liquid Chromatography-Mass Spectrometry Profiling of Bile Acid Metabolites in Biofluids: Application to Experimental Toxicology Studies, ANALYTICAL CHEMISTRY, Vol: 82, Pages: 5282-5289, ISSN: 0003-2700
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- Citations: 75
Cavill R, Sidhu JK, Kilarski W, et al., 2010, A Combined Metabonomic and Transcriptomic Approach to Investigate Metabolism during Development in the Chick Chorioallantoic Membrane, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 3126-3134, ISSN: 1535-3893
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- Citations: 11
Ellis JK, Chan PH, Doktorova T, et al., 2010, Effect of the Histone Deacetylase Inhibitor Trichostatin A on the Metabolome of Cultured Primary Hepatocytes, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 413-419, ISSN: 1535-3893
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- Citations: 13
Bollard ME, Contel NR, Ebbels TMD, et al., 2010, NMR-Based Metabolic Profiling Identifies Biomarkers of Liver Regeneration Following Partial Hepatectomy in the Rat, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 59-69, ISSN: 1535-3893
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- Citations: 71
Beckonert O, Coen M, Keun HC, et al., 2010, High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues, NATURE PROTOCOLS, Vol: 5, Pages: 1019-1032, ISSN: 1754-2189
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- Citations: 287
Teichert F, Verschoyle RD, Greaves P, et al., 2010, Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer, MOLECULAR BIOSYSTEMS, Vol: 6, Pages: 1911-1916, ISSN: 1742-206X
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- Citations: 5
Fletcher M, Boshier P, Smolenski RT, et al., 2009, MOLECULAR MECHANISMS OF LUNG EPITHELIAL CELL INJURY INDUCED BY INHIBITION OF GLUTATHIONE-<i>S</i>-TRANSFERASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A38-A39, ISSN: 0040-6376
Bohus E, Racz A, Noszal B, et al., 2009, Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 47, Pages: S26-S35, ISSN: 0749-1581
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- Citations: 13
Keun HC, Sidhu J, Pchejetski D, et al., 2009, Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy, CLINICAL CANCER RESEARCH, Vol: 15, Pages: 6716-6723, ISSN: 1078-0432
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- Citations: 47
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