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@article{Maitre:2018:10.1136/bmjopen-2017-021311,
author = {Maitre, L and de, Bont J and Casas, M and Robinson, O and Aasvang, GM and Agier, L and Andruaityt, S and Ballester, F and Basagaña, X and Borràs, E and Brochot, C and Bustamante, M and Carracedo, A and de, Castro M and Dedele, A and Donaire-Gonzalez, D and Estivill, X and Evandt, J and Fossati, S and Giorgis-Allemand, L and R, Gonzalez J and Granum, B and Grazuleviciene, R and Bjerve, Gützkow K and Småstuen, Haug L and Hernandez-Ferrer, C and Heude, B and Ibarluzea, J and Julvez, J and Karachaliou, M and Keun, HC and Hjertager, Krog N and Lau, C-HE and Leventakou, V and Lyon-Caen, S and Manzano, C and Mason, D and McEachan, R and Meltzer, HM and Petraviciene, I and Quentin, J and Roumeliotaki, T and Sabido, E and Saulnier, P-J and Siskos, AP and Siroux, V and Sunyer, J and Tamayo, I and Urquiza, J and Vafeiadi, M and van, Gent D and Vives-Usano, M and Waiblinger, D and Warembourg, C and Chatzi, L and Coen, M and van, den Hazel P and Nieuwenhuijsen, MJ and Slama, R and Thomsen, C and Wr},
doi = {10.1136/bmjopen-2017-021311},
journal = {BMJ Open},
title = {Human Early Life Exposome (HELIX) study: a European population-based exposome cohort},
url = {http://dx.doi.org/10.1136/bmjopen-2017-021311},
volume = {8},
year = {2018}
}

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TY  - JOUR
AB  - Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations.Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31 472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6–11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level).Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6–11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder.Future plans HELIX study results will inform on the early life exposome and its association with molecul
AU  - Maitre,L
AU  - de,Bont J
AU  - Casas,M
AU  - Robinson,O
AU  - Aasvang,GM
AU  - Agier,L
AU  - Andruaityt,S
AU  - Ballester,F
AU  - Basagaña,X
AU  - Borràs,E
AU  - Brochot,C
AU  - Bustamante,M
AU  - Carracedo,A
AU  - de,Castro M
AU  - Dedele,A
AU  - Donaire-Gonzalez,D
AU  - Estivill,X
AU  - Evandt,J
AU  - Fossati,S
AU  - Giorgis-Allemand,L
AU  - R,Gonzalez J
AU  - Granum,B
AU  - Grazuleviciene,R
AU  - Bjerve,Gützkow K
AU  - Småstuen,Haug L
AU  - Hernandez-Ferrer,C
AU  - Heude,B
AU  - Ibarluzea,J
AU  - Julvez,J
AU  - Karachaliou,M
AU  - Keun,HC
AU  - Hjertager,Krog N
AU  - Lau,C-HE
AU  - Leventakou,V
AU  - Lyon-Caen,S
AU  - Manzano,C
AU  - Mason,D
AU  - McEachan,R
AU  - Meltzer,HM
AU  - Petraviciene,I
AU  - Quentin,J
AU  - Roumeliotaki,T
AU  - Sabido,E
AU  - Saulnier,P-J
AU  - Siskos,AP
AU  - Siroux,V
AU  - Sunyer,J
AU  - Tamayo,I
AU  - Urquiza,J
AU  - Vafeiadi,M
AU  - van,Gent D
AU  - Vives-Usano,M
AU  - Waiblinger,D
AU  - Warembourg,C
AU  - Chatzi,L
AU  - Coen,M
AU  - van,den Hazel P
AU  - Nieuwenhuijsen,MJ
AU  - Slama,R
AU  - Thomsen,C
AU  - Wright,J
AU  - Vrijheid,M
DO  - 10.1136/bmjopen-2017-021311
PY  - 2018///
SN  - 2044-6055
TI  - Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2017-021311
UR  - http://hdl.handle.net/10044/1/64064
VL  - 8
ER  -

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