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@article{Kliemann:2021:10.1186/s12916-021-01970-1,
author = {Kliemann, N and Viallon, V and Murphy, N and Beeken, RJ and Rothwell, JA and Rinaldi, S and Assi, N and van, Roekel EH and Schmidt, JA and Borch, KB and Agnoli, C and Rosendahl, AH and Sartor, H and Huerta, JM and Tjonneland, A and Halkjaer, J and Bueno-de-Mesquita, B and Gicquiau, A and Achaintre, D and Aleksandrova, K and Schulze, MB and Heath, AK and Tsilidis, KK and Masala, G and Panico, S and Kaaks, R and Fortner, RT and Van, Guelpen B and Dossus, L and Scalbert, A and Keun, HC and Travis, RC and Jenab, M and Johansson, M and Ferrari, P and Gunter, MJ},
doi = {10.1186/s12916-021-01970-1},
journal = {BMC Medicine},
title = {Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition},
url = {http://dx.doi.org/10.1186/s12916-021-01970-1},
volume = {19},
year = {2021}
}

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TY  - JOUR
AB  - Background:The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.Methods:Targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and 17 individuals from a single-arm pilot weight loss intervention (Intercept) were used in this analysis. Metabolic signatures of body size were first determined in discovery (N = 3029) and replication (N = 1297) sets among EPIC participants by testing the associations between 129 metabolites and body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) using linear regression models followed by partial least squares analyses. Conditional logistic regression models assessed the associations between the metabolic signatures with endometrial (N = 635 cases and 648 controls) and colorectal (N = 423 cases and 423 controls) cancer risk using nested case-control studies in EPIC. Pearson correlation between changes in the metabolic signatures and weight loss was tested among Intercept participants.Results:After adjustment for multiple comparisons, greater BMI, WC, and WHR were associated with higher levels of valine, isoleucine, glutamate, PC aa C38:3, and PC aa C38:4 and with lower levels of asparagine, glutamine, glycine, serine, lysoPC C17:0, lysoPC C18:1, lysoPC C18:2, PC aa C42:0, PC ae C34:3, PC ae C40:5, and PC ae C42:5. The metabolic signature of BMI (OR1-sd 1.50, 95% CI 1.30–1.74), WC (OR1-sd 1.46, 95% CI 1.27–1.69), and WHR (OR1-sd 1.54, 95% CI 1.33–1.79) were each associated with endometrial cancer risk. Risk of colorectal cancer was positively associated with
AU  - Kliemann,N
AU  - Viallon,V
AU  - Murphy,N
AU  - Beeken,RJ
AU  - Rothwell,JA
AU  - Rinaldi,S
AU  - Assi,N
AU  - van,Roekel EH
AU  - Schmidt,JA
AU  - Borch,KB
AU  - Agnoli,C
AU  - Rosendahl,AH
AU  - Sartor,H
AU  - Huerta,JM
AU  - Tjonneland,A
AU  - Halkjaer,J
AU  - Bueno-de-Mesquita,B
AU  - Gicquiau,A
AU  - Achaintre,D
AU  - Aleksandrova,K
AU  - Schulze,MB
AU  - Heath,AK
AU  - Tsilidis,KK
AU  - Masala,G
AU  - Panico,S
AU  - Kaaks,R
AU  - Fortner,RT
AU  - Van,Guelpen B
AU  - Dossus,L
AU  - Scalbert,A
AU  - Keun,HC
AU  - Travis,RC
AU  - Jenab,M
AU  - Johansson,M
AU  - Ferrari,P
AU  - Gunter,MJ
DO  - 10.1186/s12916-021-01970-1
PY  - 2021///
SN  - 1741-7015
TI  - Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-021-01970-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000651471000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/89056
VL  - 19
ER  -

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