Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dossus:2021:10.1016/j.ygyno.2021.06.001,
author = {Dossus, L and Kouloura, E and Biessy, C and Viallon, V and Siskos, AP and Dimou, N and Rinaldi, S and Merritt, MA and Allen, N and Fortner, R and Kaaks, R and Weiderpass, E and Gram, IT and Rothwell, JA and Lécuyer, L and Severi, G and Schulze, MB and Nøst, TH and Crous-Bou, M and Sánchez, M-J and Amiano, P and Colorado-Yohar, SM and Gurrea, AB and Schmidt, JA and Palli, D and Agnoli, C and Tumino, R and Sacerdote, C and Mattiello, A and Vermeulen, R and Heath, AK and Christakoudi, S and Tsilidis, KK and Travis, RC and Gunter, MJ and Keun, HC},
doi = {10.1016/j.ygyno.2021.06.001},
journal = {Gynecol Oncol},
pages = {475--481},
title = {Prospective analysis of circulating metabolites and endometrial cancer risk.},
url = {http://dx.doi.org/10.1016/j.ygyno.2021.06.001},
volume = {162},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed. RESULTS: After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR1SD: 1.18, 95% CI: 1.05-1.33), and glycine, serine, and free carnitine (C0) were inversely (OR1SD: 0.89, 95% CI: 0.80-0.99; OR1SD: 0.89, 95% CI: 0.79-1.00 and OR1SD: 0.91, 95% CI: 0.81-1.00, respectively) associated with endometrial cancer risk. Serine, C0 and two sphingomyelins were selected by the lasso method in >90% of the bootstrap samples. The ratio of esterified to free carnitine (OR1SD: 1.14, 95% CI: 1.02-1.28) and that of short chain to free acylcarnitines (OR1SD: 1.12, 95% CI: 1.00-1.25) were positively associated with endometrial cancer risk. Further adjustment for C-peptide or other endometrial cancer risk factors only minimally altered the results. CONCLUSION: These findings suggest that variation in levels of glycine, serine, SM C18:0 and free carnitine may represent specific pathways linked to endometrial cancer development. If causal, these pathways may offer novel targets for endometrial cancer prevention.
AU  - Dossus,L
AU  - Kouloura,E
AU  - Biessy,C
AU  - Viallon,V
AU  - Siskos,AP
AU  - Dimou,N
AU  - Rinaldi,S
AU  - Merritt,MA
AU  - Allen,N
AU  - Fortner,R
AU  - Kaaks,R
AU  - Weiderpass,E
AU  - Gram,IT
AU  - Rothwell,JA
AU  - Lécuyer,L
AU  - Severi,G
AU  - Schulze,MB
AU  - Nøst,TH
AU  - Crous-Bou,M
AU  - Sánchez,M-J
AU  - Amiano,P
AU  - Colorado-Yohar,SM
AU  - Gurrea,AB
AU  - Schmidt,JA
AU  - Palli,D
AU  - Agnoli,C
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Mattiello,A
AU  - Vermeulen,R
AU  - Heath,AK
AU  - Christakoudi,S
AU  - Tsilidis,KK
AU  - Travis,RC
AU  - Gunter,MJ
AU  - Keun,HC
DO  - 10.1016/j.ygyno.2021.06.001
EP  - 481
PY  - 2021///
SP  - 475
TI  - Prospective analysis of circulating metabolites and endometrial cancer risk.
T2  - Gynecol Oncol
UR  - http://dx.doi.org/10.1016/j.ygyno.2021.06.001
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34099314
UR  - http://hdl.handle.net/10044/1/92849
VL  - 162
ER  -
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