Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rana:2022:10.1038/s41416-021-01677-3,
author = {Rana, S and Valbuena, GN and Curry, E and Bevan, CL and Keun, HC},
doi = {10.1038/s41416-021-01677-3},
journal = {British Journal of Cancer},
pages = {502--513},
title = {MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data},
url = {http://dx.doi.org/10.1038/s41416-021-01677-3},
volume = {126},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundReliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated microRNAs (miRs) as PCa prognostic biomarkers, often reporting inconsistent findings. We present a systematic review of these; also systematic reanalysis of public miR-profile datasets to identify tissue-derived miRs prognostic of biochemical recurrence (BCR) in patients undergoing radical prostatectomy.MethodsIndependent PubMed searches were performed for relevant articles from January 2007 to December 2019. For the review, 128 studies were included. Pooled-hazard-ratios (HRs) for miRs in multiple studies were calculated using a random-effects model (REM). For the reanalysis, five studies were included and Cox proportional-hazard models, testing miR association with BCR, performed for miRs profiled in all.ResultsSystematic review identified 120 miRs as prognostic. Five (let-7b-5p, miR-145-5p, miR152-3p, miR-195-5p, miR-224-5p) were consistently associated with progression in multiple cohorts/studies. In the reanalysis, ten (let-7a-5p, miR-148a-3p, miR-203a-3p, miR-26b-5p, miR30a-3p, miR-30c-5p, miR-30e-3p, miR-374a-5p, miR-425-3p, miR-582-5p) were significantly prognostic of BCR. Of these, miR-148a-3p (HR = 0.80/95% CI = 0.68-0.94) and miR-582-5p (HR = 0.73/95% CI = 0.61-0.87) were also reported in prior publication(s) in the review.ConclusionsFifteen miRs were consistently associated with disease progression in multiple publications or datasets. Further research into their biological roles is warranted to support investigations into their performance as prognostic PCa biomarkers.
AU  - Rana,S
AU  - Valbuena,GN
AU  - Curry,E
AU  - Bevan,CL
AU  - Keun,HC
DO  - 10.1038/s41416-021-01677-3
EP  - 513
PY  - 2022///
SN  - 0007-0920
SP  - 502
TI  - MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data
T2  - British Journal of Cancer
UR  - http://dx.doi.org/10.1038/s41416-021-01677-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000741878100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41416-021-01677-3
UR  - http://hdl.handle.net/10044/1/94157
VL  - 126
ER  -
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