Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maitre:2022:10.1038/s41467-022-34422-2,
author = {Maitre, L and Bustamante, M and Hernandez-Ferrer, C and Thiel, D and Lau, C-HE and Siskos, A and Vives-Usano, M and Ruiz-Arenas, C and Pelegri-Siso, D and Robinson, O and Mason, D and Wright, J and Cadiou, S and Slama, R and Heude, B and Casas, M and Sunyer, J and Papadopoulou, EZ and Gutzkow, KB and Andrusaityte, S and Grazuleviciene, R and Vafeiadi, M and Chatzi, L and Sakhi, AK and Thomsen, C and Tamayo, I and Nieuwenhuijsen, M and Urquiza, J and Borras, E and Sabido, E and Quintela, I and Carracedo, A and Estivill, X and Coen, M and Gonzalez, JR and Keun, HC and Vrijheid, M},
doi = {10.1038/s41467-022-34422-2},
journal = {Nature Communications},
pages = {1--18},
title = {Multi-omics signatures of the human early life exposome},
url = {http://dx.doi.org/10.1038/s41467-022-34422-2},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome.
AU  - Maitre,L
AU  - Bustamante,M
AU  - Hernandez-Ferrer,C
AU  - Thiel,D
AU  - Lau,C-HE
AU  - Siskos,A
AU  - Vives-Usano,M
AU  - Ruiz-Arenas,C
AU  - Pelegri-Siso,D
AU  - Robinson,O
AU  - Mason,D
AU  - Wright,J
AU  - Cadiou,S
AU  - Slama,R
AU  - Heude,B
AU  - Casas,M
AU  - Sunyer,J
AU  - Papadopoulou,EZ
AU  - Gutzkow,KB
AU  - Andrusaityte,S
AU  - Grazuleviciene,R
AU  - Vafeiadi,M
AU  - Chatzi,L
AU  - Sakhi,AK
AU  - Thomsen,C
AU  - Tamayo,I
AU  - Nieuwenhuijsen,M
AU  - Urquiza,J
AU  - Borras,E
AU  - Sabido,E
AU  - Quintela,I
AU  - Carracedo,A
AU  - Estivill,X
AU  - Coen,M
AU  - Gonzalez,JR
AU  - Keun,HC
AU  - Vrijheid,M
DO  - 10.1038/s41467-022-34422-2
EP  - 18
PY  - 2022///
SN  - 2041-1723
SP  - 1
TI  - Multi-omics signatures of the human early life exposome
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-34422-2
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000886222800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.nature.com/articles/s41467-022-34422-2
UR  - http://hdl.handle.net/10044/1/101587
VL  - 13
ER  -
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